{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T02:47:12Z","timestamp":1788922032545,"version":"build-2803163510"},"reference-count":29,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2021,2,10]],"date-time":"2021-02-10T00:00:00Z","timestamp":1612915200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Euro J of Neurology"],"published-print":{"date-parts":[[2021,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and purpose<\/jats:title><jats:p>Central retinal artery occlusion (CRAO) is a neuro\u2010ophthalmological emergency necessitating adequate and comprehensive diagnosis. Its optimal management and treatment, however, are still under debate. This study aimed at identifying respective areas for improvement.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We retrospectively analysed the medical records of patients with CRAO treated in our stroke unit between January 2016 and August 2020.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>During the observational period, 101 patients with CRAO were admitted. We observed an increase in the rate of patients primarily admitted to the stroke unit from 52.2% to 97.4%. In addition, the thrombolysis rate \u2013 with thrombolysis performed on an individual basis \u2013 rose from 0% to 14.1%, coinciding with the implementation of an in\u2010hospital management guideline. Almost 60% of all patients presented outside of the 4.5\u2010h time window for thrombolysis; by far the most common reason not to deliver intravenous thrombolysis in our cohort was a prehospital delay to presentation (58.8%), with 44.4% of patients having consulted a private\u2010practice ophthalmologist first. A total of 25 (32.5%) of 77 patients who underwent magnetic resonance imaging (MRI) had accompanying acute ischaemic stroke lesions on diffusion\u2010weighted MRI of the brain. A possible aetiology of CRAO was identified in 41.4% of patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Discussion<\/jats:title><jats:p>Public awareness of sudden unilateral visual loss as a presenting sign for stroke should be raised, increasing the chances for timely recognition in a hospital with ophthalmological expertise and a stroke centre. This is essential for ongoing and future prospective trials on this subject.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ene.14735","type":"journal-article","created":{"date-parts":[[2021,1,16]],"date-time":"2021-01-16T09:28:11Z","timestamp":1610789291000},"page":"2111-2114","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":24,"title":["Central retinal artery occlusion as a neuro\u2010ophthalmological emergency: the need to raise public awareness"],"prefix":"10.1111","volume":"28","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5672-0865","authenticated-orcid":false,"given":"Carolin","family":"Hoyer","sequence":"first","affiliation":[{"name":"Department of Neurology Medical Faculty Mannheim University Medical Centre Mannheim Heidelberg University Mannheim Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Kahlert","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology 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