{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T09:00:25Z","timestamp":1790758825309,"version":"4.1.0"},"reference-count":19,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2021,2,19]],"date-time":"2021-02-19T00:00:00Z","timestamp":1613692800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Euro J of Neurology"],"published-print":{"date-parts":[[2021,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and objective<\/jats:title><jats:p>The prognosis in myelin oligodendrocyte glycoprotein (MOG) antibody\u2010associated disease (MOGAD) is a matter of debate. Our aim was to assess the long\u2010term outcomes of patients with MOGAD.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We retrospectively analysed the clinical and paraclinical data of patients from the French nationwide observatory study NOMADMUS who tested positive for MOG antibodies (MOG\u2010IgG) and who had clinical follow\u2010up of at least 8\u00a0years from their first episode.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Sixty\u2010one patients (median [range] age at onset 27 [3\u201369] years), with a median (mean; range) follow\u2010up of 177\u00a0(212.8; 98\u2013657) months, were included. Among 58 patients with a relapsing course, 26.3% relapsed in the first year after onset. Of the 61 patients, 90.2% experienced at least one episode of optic neuritis. At last visit, the median (mean; range) Expanded Disability Status Scale (EDSS) score was 1 (2.12; 0\u20137.5), 12.5% had an EDSS score \u22656 and 37.5% had an EDSS score \u22653. Of 51 patients with final visual acuity (VA) data available, 15.7% had VA \u22640.1 in at least one eye and 25.5% had VA \u22640.5 in at least one eye. Bilateral blindness (VA \u22640.1) was present in 5.9% of patients. Finally, 12.5% of patients presented bladder dysfunction requiring long\u2010term urinary catheterization. No factor associated significantly with a final EDSS score \u22653 or with final VA \u22640.1 was found.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Overall long\u2010term favourable outcomes were achieved in a majority of our patients, but severe impairment, in particular visual damage, was not uncommon.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ene.14746","type":"journal-article","created":{"date-parts":[[2021,2,6]],"date-time":"2021-02-06T02:24:13Z","timestamp":1612578253000},"page":"1659-1664","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":55,"title":["The long\u2010term outcome of MOGAD: An observational national cohort study of 61 patients"],"prefix":"10.1111","volume":"28","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6291-8771","authenticated-orcid":false,"given":"Romain","family":"Deschamps","sequence":"first","affiliation":[{"name":"Department of Neurology H\u00f4pital Fondation 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of Neurology University Hospital of Strasbourg Strasbourg France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bertrand","family":"Audoin","sequence":"additional","affiliation":[{"name":"Department of Neurology P\u00f4le de Neurosciences Cliniques, APHM H\u00f4pital de la Timone Aix Marseille University Marseille France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4029-2012","authenticated-orcid":false,"given":"H\u00e9l\u00e8ne","family":"Z\u00e9phir","sequence":"additional","affiliation":[{"name":"Department of Neurology U 1172, CRC\u2010SEP University Hospital of Lille Lille France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan","family":"Ciron","sequence":"additional","affiliation":[{"name":"Department of Neurology University Hospital of Toulouse Toulouse 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