{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,18]],"date-time":"2026-10-18T05:17:56Z","timestamp":1792300676366,"version":"4.4.0"},"reference-count":37,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2021,2,3]],"date-time":"2021-02-03T00:00:00Z","timestamp":1612310400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Euro J of Neurology"],"published-print":{"date-parts":[[2021,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To describe the spectrum of neurological complications observed in a hospital\u2010based cohort of COVID\u201019 patients who required a neurological assessment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We conducted an observational, monocentric, prospective study of patients with a COVID\u201019 diagnosis hospitalized during the 3\u2010month period of the first wave of the COVID\u201019 pandemic in a tertiary hospital in Madrid (Spain). We describe the neurological diagnoses that arose after the onset of COVID\u201019 symptoms. These diagnoses could be divided into different groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Only 71 (2.6%) of 2750 hospitalized patients suffered at least one neurological complication (77 different neurological diagnoses in total) during the timeframe of the study. The most common diagnoses were neuromuscular disorders (33.7%), cerebrovascular diseases (CVDs) (27.3%), acute encephalopathy (19.4%), seizures (7.8%), and miscellanea (11.6%) comprising hiccups, myoclonic tremor, Horner syndrome and transverse myelitis. CVDs and encephalopathy were common in the early phase of the COVID\u201019 pandemic compared to neuromuscular disorders, which usually appeared later on (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.005). Cerebrospinal fluid severe acute respiratory syndrome coronavirus 2 (SARS\u2010CoV\u20102) polymerase chain reaction was negative in 15\/15 samples. The mortality was higher in the CVD group (38.1% vs. 8.9%; <jats:italic>p<\/jats:italic>\u00a0=\u00a00.05).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The prevalence of neurological complications is low in patients hospitalized for COVID\u201019. Different mechanisms appear to be involved in these complications, and there was no evidence of direct invasion of the nervous system in our cohort. Some of the neurological complications can be classified into early and late neurological complications of COVID\u201019, as they occurred at different times following the onset of COVID\u201019 symptoms.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ene.14748","type":"journal-article","created":{"date-parts":[[2021,1,21]],"date-time":"2021-01-21T08:55:38Z","timestamp":1611219338000},"page":"3339-3347","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":37,"title":["Neurological complications of COVID\u201019 in hospitalized patients: The registry of a neurology department in the first wave of the pandemic"],"prefix":"10.1111","volume":"28","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3396-4642","authenticated-orcid":false,"given":"Sof\u00eda","family":"Portela\u2010S\u00e1nchez","sequence":"first","affiliation":[{"name":"Department of Neurology Hospital General Universitario Gregorio Mara\u00f1\u00f3n Madrid 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