{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,20]],"date-time":"2026-01-20T03:49:16Z","timestamp":1768880956146,"version":"3.49.0"},"reference-count":61,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2021,2,13]],"date-time":"2021-02-13T00:00:00Z","timestamp":1613174400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/100012513","name":"Coins for Alzheimer's Research Trust","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100012513","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Euro J of Neurology"],"published-print":{"date-parts":[[2021,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>A large proportion of older adults assessed for cognitive impairment likely have hearing loss, potentially affecting accuracy of cognitive performance estimations. This study aimed to develop a hearing\u2010impaired version of the Addenbrooke's Cognitive Examination\u2010III (HI\u2010ACE\u2010III) and to assess whether the HI\u2010ACE\u2010III can accurately distinguish people with mild cognitive impairment (MCI) and dementia from cognitively intact controls.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The HI\u2010ACE\u2010III was developed by converting verbal instructions into a visual, timed PowerPoint presentation. Seventy\u2010four participants over the age of 60 years were classified into three groups: 29 had MCI, 15 had mild to moderate dementia and 30 were cognitively intact controls. Receiver operating characteristic (ROC) curves were graphed to test screening accuracy. Concurrent validity was examined through correlations between HI\u2010ACE\u2010III domain scores and relevant, visually presented standardized neuropsychological measures.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>ROC analysis for dementia revealed an area under the curve (AUC) of 0.99, achieving excellent sensitivity (100%) and good specificity (93.3%) at an optimum cut\u2010off of &lt;87. The AUC for MCI was 0.86, achieving reasonable sensitivity (75.9%) and good specificity (86.7%) at an optimum cut\u2010off of &lt;92. HI\u2010ACE\u2010III subtests shared anticipated and statistically significant correlations with established measures of cognitive functioning. Internal consistency of the HI\u2010ACE\u2010III was excellent as verified with Cronbach's alpha (<jats:italic>\u03b1<\/jats:italic>\u00a0=\u00a00.904).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Preliminarily, the HI\u2010ACE\u2010III showed good reliability, validity and screening utility for MCI and dementia in older adults in a hearing\u2010impairment context. The adapted HI\u2010ACE\u2010III may offer accurate and reliable indication of cognitive performance, supporting timely diagnosis and research examining links between hearing loss and cognitive decline.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ene.14753","type":"journal-article","created":{"date-parts":[[2021,1,24]],"date-time":"2021-01-24T07:49:03Z","timestamp":1611474543000},"page":"1820-1828","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Adaption and preliminary validation of the Addenbrooke's Cognitive Examination\u2010III as a screening test for mild cognitive impairment and dementia in hearing\u2010impaired individuals"],"prefix":"10.1111","volume":"28","author":[{"given":"Courtney","family":"North","sequence":"first","affiliation":[{"name":"Faculty of Brain Sciences UCL Division of Psychology and Language Sciences London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mary H.","family":"Heatley","sequence":"additional","affiliation":[{"name":"Faculty of Brain Sciences UCL Division of Psychology and Language Sciences London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6472-7573","authenticated-orcid":false,"given":"Nattawan","family":"Utoomprurkporn","sequence":"additional","affiliation":[{"name":"UCL Ear Institute London UK"},{"name":"Faculty of Medicine Chulalongkorn University Bangkok Thailand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Doris Eva","family":"Bamiou","sequence":"additional","affiliation":[{"name":"UCL Ear Institute London UK"},{"name":"NIHR Biomedical Research Centre Hearing and Deafness London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sergi G.","family":"Costafreda","sequence":"additional","affiliation":[{"name":"UCL Division of Psychiatry Maple House London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1361-053X","authenticated-orcid":false,"given":"Joshua","family":"Stott","sequence":"additional","affiliation":[{"name":"Faculty of Brain Sciences UCL Division of Psychology and Language Sciences London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,2,13]]},"reference":[{"key":"e_1_2_9_2_1","volume-title":"Risk reduction of cognitive decline and dementia","author":"World Health Organization","year":"2019"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(17)31073-5"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/gerona\/glr002"},{"key":"e_1_2_9_5_1","volume-title":"Health Survey for England 2014. 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