{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T18:18:37Z","timestamp":1792001917160,"version":"4.4.0"},"reference-count":30,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2021,3,30]],"date-time":"2021-03-30T00:00:00Z","timestamp":1617062400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","award":["JR19\/00037"],"award-info":[{"award-number":["JR19\/00037"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","award":["PI19\/01774"],"award-info":[{"award-number":["PI19\/01774"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002943","name":"Departament d'Innovaci\u00f3, Universitats i Empresa, Generalitat de Catalunya","doi-asserted-by":"publisher","award":["SLT008\/18\/00207"],"award-info":[{"award-number":["SLT008\/18\/00207"]}],"id":[{"id":"10.13039\/501100002943","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Euro J of Neurology"],"published-print":{"date-parts":[[2021,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and purpose<\/jats:title><jats:p>Prognosis of myasthenia gravis (MG) in patients with thymoma is not well established. Moreover, it is not clear whether thymoma recurrence or unresectable lesions entail a worse prognosis of MG.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This multicenter study was based on data\u202ffrom\u202fa\u202fSpanish neurologist\u2010driven\u202fMG registry. All patients were aged &gt;18\u00a0years\u202fat\u202fonset\u202fand had anti\u2010acetylcholine receptor antibodies.\u202fWe compared the clinical data of thymomatous and nonthymomatous patients.\u202fPrognosis of patients with recurrent or nonresectable thymomas was assessed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We included 964 patients from 15 hospitals; 148 (15.4%) had thymoma\u2010associated MG. Median follow\u2010up time was 4.6\u00a0years. At onset, thymoma\u2010associated MG patients were younger (52.0 vs. 60.4 years, <jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.001), had more generalized symptoms (odds ratio [OR]: 3.02, 95% confidence interval [CI]: 1.95\u20134.68, <jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.001) and more severe clinical forms according to the Myasthenia Gravis Foundation of America (MGFA) scale (OR: 1.6, 95% CI: 1.15\u20132.21, <jats:italic>p<\/jats:italic>\u00a0=\u00a00.005). Disease severity based on MGFA postintervention status (MGFA\u2010PIS) was higher in thymomatous patients at 1\u00a0year, 5\u00a0years, and the end of follow\u2010up. Treatment refractoriness and mortality were also higher (OR: 2.28, 95% CI: 1.43\u20133.63, <jats:italic>p<\/jats:italic>\u00a0=\u00a00.001; hazard ratio: 2.46, 95% CI: 1.47\u20134.14, <jats:italic>p<\/jats:italic>\u00a0=\u00a00.001). Myasthenic symptoms worsened in 13 of 27 patients with recurrences, but differences in long\u2010term severity were not significant. Fifteen thymomatous patients had nonresectable thymomas with worse MGFA\u2010PIS and higher mortality at the end of follow\u2010up.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Thymoma\u2010associated MG patients had more severe myasthenic symptoms and worse prognosis. Thymoma recurrence was frequently associated with transient worsening of MG, but long\u2010term prognosis did not differ from nonrecurrent thymoma. Patients with nonresectable thymoma tended to present severe forms of MG.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ene.14820","type":"journal-article","created":{"date-parts":[[2021,3,15]],"date-time":"2021-03-15T16:55:50Z","timestamp":1615827350000},"page":"2083-2091","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":104,"title":["Clinical characteristics and outcomes of thymoma\u2010associated myasthenia gravis"],"prefix":"10.1111","volume":"28","author":[{"given":"Rodrigo","family":"\u00c1lvarez\u2010Velasco","sequence":"first","affiliation":[{"name":"Neuromuscular Diseases Unit Department of Neurology Hospital de la Santa Creu i Sant Pau Barcelona Spain"},{"name":"Department of Medicine Universitat Aut\u00f3noma de Barcelona Barcelona Spain"},{"name":"Biomedical Research Institute Sant Pau (IIB Sant Pau) Barcelona Spain"},{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Raras (CIBERER) Instituto de Salud Carlos III Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gerardo","family":"Guti\u00e9rrez\u2010Guti\u00e9rrez","sequence":"additional","affiliation":[{"name":"Department of Neurology Hospital Universitario Infanta Sof\u00eda Universidad Europea de Madrid San Sebasti\u00e1n de los Reyes Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan Carlos","family":"Trujillo","sequence":"additional","affiliation":[{"name":"Department of Medicine Universitat Aut\u00f3noma de Barcelona Barcelona Spain"},{"name":"Department of Thoracic Surgery Hospital de la Santa Creu i Sant Pau Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elisabeth","family":"Mart\u00ednez","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery Hospital de la Santa Creu i Sant Pau Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sonia","family":"Segovia","sequence":"additional","affiliation":[{"name":"Neuromuscular Diseases Unit Department of Neurology Hospital de la Santa Creu i Sant Pau Barcelona Spain"},{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Raras (CIBERER) Instituto de Salud Carlos III Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marina","family":"Arribas\u2010Velasco","sequence":"additional","affiliation":[{"name":"Department of Neurology Hospital Universitario Infanta Sof\u00eda Universidad Europea de Madrid San Sebasti\u00e1n de los Reyes Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guillermo","family":"Fern\u00e1ndez","sequence":"additional","affiliation":[{"name":"Department of Neurology Hospital Universitario Infanta Sof\u00eda Universidad Europea de Madrid San Sebasti\u00e1n de los Reyes Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carmen","family":"Paradas","sequence":"additional","affiliation":[{"name":"Neurology Department Neuromuscular Disorders Unit Instituto de Biomedicina de Sevilla Hospital U. 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