{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,4]],"date-time":"2026-04-04T01:41:45Z","timestamp":1775266905270,"version":"3.50.1"},"reference-count":5,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2021,6,10]],"date-time":"2021-06-10T00:00:00Z","timestamp":1623283200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Euro J of Neurology"],"published-print":{"date-parts":[[2021,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and purpose<\/jats:title><jats:p>Creutzfeldt\u2013Jakob disease (CJD) is a rare form of rapidly progressive neurodegenerative disorder. Seizures are uncommon in the early stage of CJD, increasing diagnostic difficulty.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>An autopsy\u2010proven case of CJD presenting initially as an epilepsia partialis continua is reported, in which the initial workup was unremarkable. Retrospectively, the presence of nystagmus, which proved to be non\u2010epileptic, pointed to a cerebellar lesion before a diagnosis of clinically probable CJD was made.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A 70\u2010year\u2010old man presented with a 3\u2010week history of intermittent rhythmic jerking tremors in his left limbs, interfering with his gait. Examination showed left body clonic movements. Electroencephalography revealed an ictal right centroparietal pattern of focal status epilepticus. Video\u2010oculography revealed right\u2010beating nystagmus (mean slow phase velocity [SPV] 3.4\u00ba\/s) in the dark and left\u2010beating nystagmus (SPV 2.6\u00ba\/s) in the light, left\u2010beating nystagmus after head shaking (SPV 4\u00ba\/s) and during mastoid vibration (SPV 11\u00ba\/s) and mildly hypoactive horizontal head impulses. Search for occult malignancy, serologies, cerebrospinal fluid analyses, anti\u2010onconeural antigen, auto\u2010immune panel and brain magnetic resonance imaging were unrevealing. Rapid neurological decline was observed. Three weeks later, cerebrospinal fluid was positive for 14.3.3 protein, electroencephalography showed generalized periodic sharp wave complexes and brain magnetic resonance imaging revealed diffusion restriction and T2\/fluid\u2010attenuated inversion recovery hyperintensities in the cerebellum, basal ganglia, thalamus and cortex. He died 1 month later. Neuropathological study confirmed the diagnosis of CJD.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>This case highlights that CJD should be considered in the differential diagnosis of new onset epilepsia partialis continua and that neuro\u2010ophthalmological examination can be helpful in pointing to early asymmetric cerebellar involvement.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ene.14847","type":"journal-article","created":{"date-parts":[[2021,3,31]],"date-time":"2021-03-31T05:51:50Z","timestamp":1617169910000},"page":"2456-2459","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Sporadic Creutzfeldt\u2013Jakob disease presenting as <i>epilepsia partialis continua<\/i> and non\u2010ictal nystagmus"],"prefix":"10.1111","volume":"28","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7921-8341","authenticated-orcid":false,"given":"In\u00eas Antunes","family":"Cunha","sequence":"first","affiliation":[{"name":"Neurology Department Coimbra University and Hospital Centre Coimbra Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4166-640X","authenticated-orcid":false,"given":"In\u00eas","family":"Gomes","sequence":"additional","affiliation":[{"name":"Neurology Department Coimbra University and Hospital Centre Coimbra Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Helena","family":"Gens","sequence":"additional","affiliation":[{"name":"Neurology Department Coimbra University and Hospital Centre Coimbra Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Susana","family":"Guimar\u00e3es","sequence":"additional","affiliation":[{"name":"Pathology Department S\u00e3o Jo\u00e3o Hospital Porto Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ana In\u00eas","family":"Martins","sequence":"additional","affiliation":[{"name":"Neurology Department Coimbra University and Hospital Centre Coimbra Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Concei\u00e7\u00e3o","family":"Bento","sequence":"additional","affiliation":[{"name":"Neurology Department Coimbra University and Hospital Centre Coimbra Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,6,10]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1684\/epd.2011.0400"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1159\/000503274"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1159\/000490909"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410340215"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/nan.12461"}],"container-title":["European Journal of Neurology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ene.14847","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/ene.14847","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ene.14847","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,28]],"date-time":"2023-08-28T11:57:26Z","timestamp":1693223846000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/ene.14847"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,6,10]]},"references-count":5,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2021,7]]}},"alternative-id":["10.1111\/ene.14847"],"URL":"https:\/\/doi.org\/10.1111\/ene.14847","archive":["Portico"],"relation":{},"ISSN":["1351-5101","1468-1331"],"issn-type":[{"value":"1351-5101","type":"print"},{"value":"1468-1331","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,6,10]]},"assertion":[{"value":"2021-02-28","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-03-17","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-06-10","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}