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In addition to cluster headache, TACs include hemicrania continua, paroxysmal hemicrania, and short\u2010lasting unilateral neuralgiform headache with conjunctival injection and tearing\/autonomic symptoms (SUNCT\/SUNA). Treating these rare, severe headache conditions often requires off\u2010label drugs that have uncertain teratogenic potential. In the last few years, several new treatment options and safety documentation have emerged, but clinical guidelines are lacking. 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