{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,5]],"date-time":"2026-01-05T21:51:18Z","timestamp":1767649878917,"version":"3.40.5"},"reference-count":27,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2021,6,23]],"date-time":"2021-06-23T00:00:00Z","timestamp":1624406400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100012659","name":"Foundation for Innovative Research Groups of the National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81701039","81870843"],"award-info":[{"award-number":["81701039","81870843"]}],"id":[{"id":"10.13039\/501100012659","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Euro J of Neurology"],"published-print":{"date-parts":[[2021,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and purpose<\/jats:title><jats:p>The aim of this study was to discover the associations between <jats:italic>HMOX\u20101<\/jats:italic> and Alzheimer's disease (AD).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A total of 500 AD patients and 500 healthy controls were recruited in this study. Polymer chain reaction was used.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>There was a statistically significant difference between AD patients and controls in both the dominant and recessive models of <jats:italic>HMOX\u20101<\/jats:italic> rs2071746 after adjustment for age, gender and education (dominant model: <jats:italic>p<\/jats:italic> = 0.047, odds ratio [OR] 1.34, 95% confidence interval [CI] 1.00\u20131.78, adjusted; recessive model: <jats:italic>p<\/jats:italic> = 0.049, OR 1.34, 95% CI 1.00\u20131.80, adjusted). There was also a trend for an association between the dominant model and late\u2010onset AD after adjustment for age, gender and education (dominant model: <jats:italic>p<\/jats:italic> = 0.084, OR 1.37, 95% CI 0.96\u20131.95, adjusted).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>We found an association between the dominant and recessive models of <jats:italic>HMOX1<\/jats:italic> rs2071746 and AD.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ene.14870","type":"journal-article","created":{"date-parts":[[2021,4,17]],"date-time":"2021-04-17T09:17:31Z","timestamp":1618651051000},"page":"2922-2926","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Association of <i>HMOX\u20101<\/i> with sporadic Alzheimer\u2019s disease in southern Han 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