{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T06:37:08Z","timestamp":1790663828544,"version":"4.1.0"},"reference-count":46,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2021,6,19]],"date-time":"2021-06-19T00:00:00Z","timestamp":1624060800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100011789","name":"Department of Science and Technology of Jilin Province","doi-asserted-by":"publisher","award":["20180623052TC"],"award-info":[{"award-number":["20180623052TC"]}],"id":[{"id":"10.13039\/501100011789","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Euro J of Neurology"],"published-print":{"date-parts":[[2021,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and purpose<\/jats:title><jats:p>To test the hypothesis that \u201cobesity paradox\u201d exists in stroke patients, we conducted a meta\u2010analysis and systematic review on the association between abnormal body weight (obesity, overweight, or underweight) and the outcome of different types of stroke.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This meta\u2010analysis and systematic review was performed in conformity to the PRISMA (Preferred Reporting Items for Systematic Reviews and Meta\u2010Analysis) guidelines in Appendix S2. Studies investigating the association between abnormal body weight and the outcome of different types of stroke were searched for in the PubMed and Embase databases from their inception to 20 March 2021.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Thirty\u2010three articles including 84,660 patients were included in this study. Obesity and overweight were associated with longer survival in mixed\u2010stroke patients (acute ischemic stroke [AIS] combined with one or more other stroke subtypes) than was normal weight, whereas underweight was related to shorter survival; the pooled hazard ratios (HRs) of mortality were 0.77 (95% confidence interval [CI] = 0.71\u20130.83) for obesity, 0.76 (95% CI = 0.72\u20130.80) for overweight, and 1.71 (95% CI = 1.56\u20131.87) for underweight. However, only obesity was associated with longer survival in AIS patients compared with normal weight, and underweight was related to shorter survival; the pooled HR of mortality was 0.75 (95% CI = 0.64\u20130.88) for obesity and 1.53 (95% CI = 1.27\u20131.85) for underweight. After merging mixed\u2010stroke and AIS patients, we obtained similar results as in mixed\u2010stroke patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Our results suggested that in patients with mixed stroke or AIS, obesity was associated with a longer survival time than normal weight, whereas underweight was associated with a shorter survival time.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ene.14881","type":"journal-article","created":{"date-parts":[[2021,4,25]],"date-time":"2021-04-25T13:19:42Z","timestamp":1619356782000},"page":"2552-2564","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":29,"title":["Association between abnormal body weight and stroke outcome: A meta\u2010analysis and systematic review"],"prefix":"10.1111","volume":"28","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5536-0255","authenticated-orcid":false,"given":"Peng","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Neurology Stroke Center &amp; Clinical Trial and Research Center for Stroke First Hospital of Jilin University Chang Chun China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiu\u2010Li","family":"Yan","sequence":"additional","affiliation":[{"name":"Department of Neurology First Hospital of Jilin University Chang Chun China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Qu","sequence":"additional","affiliation":[{"name":"Department of Neurology Stroke Center &amp; Clinical Trial and Research Center for Stroke First Hospital of Jilin University Chang Chun China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhen\u2010Ni","family":"Guo","sequence":"additional","affiliation":[{"name":"Department of Neurology Stroke Center &amp; Clinical Trial and Research Center for Stroke First Hospital of Jilin University Chang Chun China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Neurology Stroke Center &amp; Clinical Trial and Research Center for Stroke First Hospital of Jilin University Chang Chun China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,6,19]]},"reference":[{"key":"e_1_2_10_2_1","unstructured":"Obesity: Preventing and managing the global epidemic. 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