{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,11]],"date-time":"2026-11-11T23:31:04Z","timestamp":1794439864427,"version":"4.9.1"},"reference-count":173,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2021,6,25]],"date-time":"2021-06-25T00:00:00Z","timestamp":1624579200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100011963","name":"European Academy of Neurology","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100011963","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Euro J of Neurology"],"published-print":{"date-parts":[[2021,9]]},"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background and aim<\/jats:title>\n                    <jats:p>Narcolepsy is an uncommon hypothalamic disorder of presumed autoimmune origin that usually requires lifelong treatment. This paper aims to provide evidence\u2010based guidelines for the management of narcolepsy in both adults and children.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>The European Academy of Neurology (EAN), European Sleep Research Society (ESRS) and European Narcolepsy Network (EU\u2010NN) nominated a task force of 18 narcolepsy specialists. According to the EAN recommendations, 10 relevant clinical questions were formulated in PICO format. Following a systematic review of the literature (performed in Fall 2018 and updated in July 2020) recommendations were developed according to the GRADE approach.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>A total of 10,247 references were evaluated, 308 studies were assessed and 155 finally included. The main recommendations can be summarized as follows: (i) excessive daytime sleepiness in adults\u2014scheduled naps, modafinil, pitolisant, sodium oxybate (SXB), solriamfetol (all strong), methylphenidate, amphetamine derivates (both weak); (ii) cataplexy in adults\u2014SXB, venlafaxine, clomipramine (all strong) and pitolisant (weak); (iii) excessive daytime sleepiness in children\u2014scheduled naps, SXB (both strong), modafinil, methylphenidate, pitolisant, amphetamine derivates (all weak); (iv) cataplexy in children\u2014SXB (strong), antidepressants (weak). Treatment choices should be tailored to each patient\u2019s symptoms, comorbidities, tolerance and risk of potential drug interactions.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The management of narcolepsy involves non\u2010pharmacological and pharmacological approaches with an increasing number of symptomatic treatment options for adults and children that have been studied in some detail.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/ene.14888","type":"journal-article","created":{"date-parts":[[2021,6,26]],"date-time":"2021-06-26T02:13:52Z","timestamp":1624673632000},"page":"2815-2830","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":129,"title":["European guideline and expert statements on the management of narcolepsy in adults and children"],"prefix":"10.1111","volume":"28","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4535-0245","authenticated-orcid":false,"given":"Claudio L. A.","family":"Bassetti","sequence":"first","affiliation":[{"name":"Department of Neurology Inselspital Bern University Hospital and University of Bern Bern Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1975-6919","authenticated-orcid":false,"given":"Ulf","family":"Kallweit","sequence":"additional","affiliation":[{"name":"Center for Narcolepsy\/Hypersomnias Clin. Sleep and Neuroimmunology Institute of Immunology University Witten\/Herdecke Witten Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9051-7091","authenticated-orcid":false,"given":"Luca","family":"Vignatelli","sequence":"additional","affiliation":[{"name":"IRCCS, Istituto delle Scienze Neurologiche di Bologna UOC Clinica Neurologica Bologna Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1051-0472","authenticated-orcid":false,"given":"Giuseppe","family":"Plazzi","sequence":"additional","affiliation":[{"name":"IRCCS, Istituto delle Scienze Neurologiche di Bologna UOC Clinica Neurologica Bologna Italy"},{"name":"Department of Biomedical, Metabolic and Neural Sciences University of Modena and Reggio Emilia Modena Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4409-2931","authenticated-orcid":false,"given":"Michel","family":"Lecendreux","sequence":"additional","affiliation":[{"name":"AP\u2010HP Pediatric Sleep Center CHU Robert\u2010Debr\u00e9 Paris France"},{"name":"National Reference Centre for Orphan Diseases, Narcolepsy, Idiopathic Hypersomnia and Kleine\u2010Levin Syndrome (CNR narcolepsie\u2010hypersomnie) Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3277-5623","authenticated-orcid":false,"given":"Elisa","family":"Baldin","sequence":"additional","affiliation":[{"name":"IRCCS, Istituto delle Scienze Neurologiche di Bologna UOC Clinica Neurologica Bologna Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8350-951X","authenticated-orcid":false,"given":"Leja","family":"Dolenc\u2010Groselj","sequence":"additional","affiliation":[{"name":"Institute of Clinical Neurophysiology University Medical Centre Ljubljana Ljubljana Slovenia"},{"name":"Department of Neurology Faculty of Medicine University of Ljubljana Ljubljana Slovenia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Poul","family":"Jennum","sequence":"additional","affiliation":[{"name":"Danish Center for Sleep Medicine Department of Clinical Neurophysiology Faculty of Health Sciences Rigshospitalet University of Copenhagen Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1092-6160","authenticated-orcid":false,"given":"Ramin","family":"Khatami","sequence":"additional","affiliation":[{"name":"Department of Neurology Inselspital Bern University Hospital and University of Bern Bern Switzerland"},{"name":"Center of Sleep Medicine Sleep Research and Epileptology. Clinic Barmelweid Barmelweid Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1849-7196","authenticated-orcid":false,"given":"Mauro","family":"Manconi","sequence":"additional","affiliation":[{"name":"Department of Neurology Inselspital Bern University Hospital and University of Bern Bern Switzerland"},{"name":"Sleep Center Faculty of Biomedical Sciences Neurocenter of Southern Switzerland Universit\u00e0 della Svizzera Italiana Lugano Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Geert","family":"Mayer","sequence":"additional","affiliation":[{"name":"Neurology Department Hephata Klinik Schwalmstadt Germany"},{"name":"Department of Neurology Philipps\u2010Universit\u00e4t Marburg Marburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8182-9368","authenticated-orcid":false,"given":"Markku","family":"Partinen","sequence":"additional","affiliation":[{"name":"Department of Clinial Neurosciences Clinicum Helsinki Sleep Clinic Vitalmed Research Center, Terveystalo Biobank and Clinical Research University of Helsinki Helsinki Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Pollm\u00e4cher","sequence":"additional","affiliation":[{"name":"Center for Mental Health Klinikum Ingolstadt Ingolstadt Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul","family":"Reading","sequence":"additional","affiliation":[{"name":"Department of Neurology James Cook University Hospital Middlesbrough UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0879-4135","authenticated-orcid":false,"given":"Joan","family":"Santamaria","sequence":"additional","affiliation":[{"name":"Neurology Service Hospital Cl\u00ednic of Barcelona Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5773-9656","authenticated-orcid":false,"given":"Karel","family":"Sonka","sequence":"additional","affiliation":[{"name":"Department of Neurology and Center of Clinical Neuroscience First Faculty of Medicine Charles University and General University Hospital Prague Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0683-6506","authenticated-orcid":false,"given":"Yves","family":"Dauvilliers","sequence":"additional","affiliation":[{"name":"National Reference Centre for Orphan Diseases, Narcolepsy, Idiopathic Hypersomnia, Sleep Unit, Department of Neurology Gui\u2010de\u2010Chauliac Hospital, CHU Montpellier University of Montpellier INM INSERM Montpellier France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4755-7060","authenticated-orcid":false,"given":"Gert J.","family":"Lammers","sequence":"additional","affiliation":[{"name":"Sleep Wake Centre SEIN Heemstede The Netherlands"},{"name":"Department of Neurology Leiden University Medical Centre Leiden The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,6,25]]},"reference":[{"key":"e_1_2_13_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41582-019-0226-9"},{"key":"e_1_2_13_3_1","first-page":"320","article-title":"Criteria for the diagnosis of the narcoleptic syndrome","volume":"32","author":"Yoss RE","year":"1957","journal-title":"Proc Staff Meet Mayo Clin"},{"key":"e_1_2_13_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(14)70218-2"},{"key":"e_1_2_13_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-018-0540-1"},{"key":"e_1_2_13_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(14)70075-4"},{"key":"e_1_2_13_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4939-6578-6_28"},{"key":"e_1_2_13_8_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.58.12.1826"},{"key":"e_1_2_13_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/jsr.12640"},{"key":"e_1_2_13_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.sleep.2006.10.010"},{"key":"e_1_2_13_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.sleep.2012.06.006"},{"key":"e_1_2_13_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.sleep.2017.07.030"},{"key":"e_1_2_13_13_1","doi-asserted-by":"publisher","DOI":"10.1080\/14656566.2017.1323877"},{"key":"e_1_2_13_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-1331.2006.01473.x"},{"key":"e_1_2_13_15_1","doi-asserted-by":"publisher","DOI":"10.1093\/sleep\/30.12.1705"},{"key":"e_1_2_13_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.smrv.2020.101306"},{"key":"e_1_2_13_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2869.2011.00943.x"},{"key":"e_1_2_13_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/ene.12818"},{"key":"e_1_2_13_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pbb.2019.172794"},{"key":"e_1_2_13_20_1","doi-asserted-by":"publisher","DOI":"10.1093\/sleep\/zsz174"},{"key":"e_1_2_13_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/jsr.12684"},{"key":"e_1_2_13_22_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000004911"},{"key":"e_1_2_13_23_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000010737"},{"key":"e_1_2_13_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.smrv.2017.04.003"},{"key":"e_1_2_13_25_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awt277"},{"key":"e_1_2_13_26_1","first-page":"SR35","article-title":"Assessment of pregnancy outcomes in Czech and Slovak women with narcolepsy","volume":"16","author":"Maurovich\u2010Horvat E","year":"2010","journal-title":"Med Sci Monit"},{"key":"e_1_2_13_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.sleep.2012.11.021"},{"key":"e_1_2_13_28_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2019.20008"},{"key":"e_1_2_13_29_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0053707"},{"key":"e_1_2_13_30_1","doi-asserted-by":"publisher","DOI":"10.5665\/sleep.2706"},{"key":"e_1_2_13_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.sleep.2016.05.011"},{"key":"e_1_2_13_32_1","doi-asserted-by":"publisher","DOI":"10.1213\/ANE.0000000000003954"},{"key":"e_1_2_13_33_1","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000175978.61048.62"},{"key":"e_1_2_13_34_1","doi-asserted-by":"publisher","DOI":"10.1093\/sleep\/12.3.254"},{"key":"e_1_2_13_35_1","doi-asserted-by":"publisher","DOI":"10.1093\/sleep\/zsaa009"},{"key":"e_1_2_13_36_1","doi-asserted-by":"publisher","DOI":"10.1093\/sleep\/32.8.979"},{"key":"e_1_2_13_37_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40263-017-0464-6"},{"key":"e_1_2_13_38_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI41366"},{"key":"e_1_2_13_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(13)70225-4"},{"key":"e_1_2_13_40_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng.372"},{"key":"e_1_2_13_41_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.22587"},{"key":"e_1_2_13_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pediatrneurol.2009.02.008"},{"key":"e_1_2_13_43_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00415-018-8949-x"},{"key":"e_1_2_13_44_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0169836"},{"key":"e_1_2_13_45_1","first-page":"42","article-title":"Specific T\u2010cell activation in peripheral blood and cerebrospinal fluid in central disorders of hypersomnolence","volume":"1","author":"Lippert J","year":"2019","journal-title":"Sleep"},{"key":"e_1_2_13_46_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1818150116"},{"key":"e_1_2_13_47_1","doi-asserted-by":"publisher","DOI":"10.1212\/01.WNL.0000101718.92619.67"},{"key":"e_1_2_13_48_1","doi-asserted-by":"publisher","DOI":"10.5665\/sleep.3300"},{"key":"e_1_2_13_49_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.sleep.2005.03.010"},{"key":"e_1_2_13_50_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1556-4029.2008.00965.x"},{"key":"e_1_2_13_51_1","doi-asserted-by":"publisher","DOI":"10.5664\/jcsm.2048"},{"key":"e_1_2_13_52_1","doi-asserted-by":"publisher","DOI":"10.1093\/sleep\/33.11.1457"},{"key":"e_1_2_13_53_1","doi-asserted-by":"publisher","DOI":"10.1093\/sleep\/28.6.667"},{"key":"e_1_2_13_54_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.sleep.2011.06.015"},{"key":"e_1_2_13_55_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00213-003-1508-9"},{"key":"e_1_2_13_56_1","doi-asserted-by":"publisher","DOI":"10.1097\/00002826-198902000-00004"},{"key":"e_1_2_13_57_1","doi-asserted-by":"publisher","DOI":"10.1159\/000116126"},{"key":"e_1_2_13_58_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0987-7053(05)80282-5"},{"key":"e_1_2_13_59_1","doi-asserted-by":"publisher","DOI":"10.1093\/sleep\/22.6.757"},{"key":"e_1_2_13_60_1","doi-asserted-by":"publisher","DOI":"10.1093\/sleep\/17.suppl_8.S107"},{"key":"e_1_2_13_61_1","doi-asserted-by":"publisher","DOI":"10.1093\/sleep\/29.7.939"},{"key":"e_1_2_13_62_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.sleep.2009.05.004"},{"key":"e_1_2_13_63_1","doi-asserted-by":"publisher","DOI":"10.5664\/jcsm.27994"},{"key":"e_1_2_13_64_1","doi-asserted-by":"publisher","DOI":"10.5664\/jcsm.27935"},{"key":"e_1_2_13_65_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.sleep.2015.05.013"},{"key":"e_1_2_13_66_1","doi-asserted-by":"publisher","DOI":"10.5664\/jcsm.4598"},{"key":"e_1_2_13_67_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.43.10.2134"},{"key":"e_1_2_13_68_1","doi-asserted-by":"publisher","DOI":"10.1097\/00002826-199304000-00004"},{"key":"e_1_2_13_69_1","doi-asserted-by":"publisher","DOI":"10.1097\/00002826-199302000-00005"},{"key":"e_1_2_13_70_1","doi-asserted-by":"publisher","DOI":"10.1097\/00002826-198908000-00012"},{"key":"e_1_2_13_71_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.smrv.2011.09.001"},{"key":"e_1_2_13_72_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.49.2.444"},{"key":"e_1_2_13_73_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.psym.2017.10.001"},{"key":"e_1_2_13_74_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2869.1995.tb00159.x"},{"key":"e_1_2_13_75_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.20603"},{"key":"e_1_2_13_76_1","doi-asserted-by":"publisher","DOI":"10.1590\/S0004-282X2007000200028"},{"key":"e_1_2_13_77_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e3181bd1344"},{"key":"e_1_2_13_78_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.20339"},{"key":"e_1_2_13_79_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.20892"},{"key":"e_1_2_13_80_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2869.2011.00985.x"},{"key":"e_1_2_13_81_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.sleep.2017.03.028"},{"key":"e_1_2_13_82_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.sleep.2013.01.007"},{"key":"e_1_2_13_83_1","doi-asserted-by":"publisher","DOI":"10.1093\/sleep\/zsy050"},{"key":"e_1_2_13_84_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00415-007-0594-8"},{"key":"e_1_2_13_85_1","first-page":"Ra177","article-title":"Modafinil for narcolepsy: systematic review and meta\u2010analysis","volume":"16","author":"Golicki D","year":"2010","journal-title":"Med Sci Monit"},{"key":"e_1_2_13_86_1","doi-asserted-by":"publisher","DOI":"10.1093\/sleep\/9.1.275"},{"key":"e_1_2_13_87_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0404.1976.tb07621.x"},{"key":"e_1_2_13_88_1","doi-asserted-by":"publisher","DOI":"10.1185\/030079906X100050"},{"key":"e_1_2_13_89_1","doi-asserted-by":"publisher","DOI":"10.1093\/sleep\/26.7.809"},{"key":"e_1_2_13_90_1","doi-asserted-by":"publisher","DOI":"10.1093\/sleep\/20.4.251"},{"key":"e_1_2_13_91_1","doi-asserted-by":"publisher","DOI":"10.1016\/0022-510X(66)90001-3"},{"key":"e_1_2_13_92_1","doi-asserted-by":"publisher","DOI":"10.5664\/jcsm.7132"},{"key":"e_1_2_13_93_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.44.11.2095"},{"key":"e_1_2_13_94_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.62.12.2300"},{"key":"e_1_2_13_95_1","doi-asserted-by":"publisher","DOI":"10.1097\/WNF.0b013e318246879d"},{"key":"e_1_2_13_96_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1440-1819.2002.00962.x"},{"key":"e_1_2_13_97_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1389-9457(03)00162-X"},{"key":"e_1_2_13_98_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jocn.2019.02.014"},{"key":"e_1_2_13_99_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e31825dce03"},{"key":"e_1_2_13_100_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0030-1267993"},{"key":"e_1_2_13_101_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2869.2010.00848.x"},{"key":"e_1_2_13_102_1","doi-asserted-by":"publisher","DOI":"10.1093\/sleep\/16.3.216"},{"key":"e_1_2_13_103_1","doi-asserted-by":"publisher","DOI":"10.5664\/jcsm.1478"},{"key":"e_1_2_13_104_1","doi-asserted-by":"publisher","DOI":"10.1093\/sleep\/24.3.282"},{"key":"e_1_2_13_105_1","doi-asserted-by":"publisher","DOI":"10.5664\/jcsm.6500"},{"key":"e_1_2_13_106_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2869.2003.00380.x"},{"key":"e_1_2_13_107_1","doi-asserted-by":"publisher","DOI":"10.5665\/sleep.1836"},{"key":"e_1_2_13_108_1","doi-asserted-by":"publisher","DOI":"10.2147\/NSS.S86649"},{"key":"e_1_2_13_109_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00213-018-5025-2"},{"key":"e_1_2_13_110_1","doi-asserted-by":"publisher","DOI":"10.1093\/sleep\/zsz220"},{"key":"e_1_2_13_111_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.sleep.2014.10.004"},{"key":"e_1_2_13_112_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.sleep.2011.10.032"},{"key":"e_1_2_13_113_1","doi-asserted-by":"publisher","DOI":"10.1097\/00002826-199508000-00002"},{"key":"e_1_2_13_114_1","doi-asserted-by":"publisher","DOI":"10.1093\/sleep\/zsy128"},{"key":"e_1_2_13_115_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000003389"},{"key":"e_1_2_13_116_1","doi-asserted-by":"publisher","DOI":"10.1097\/00004691-199001000-00008"},{"key":"e_1_2_13_117_1","first-page":"306","article-title":"Treatment of narcolepsy with methamphetamine","volume":"16","author":"Mitler MM","year":"1993","journal-title":"Sleep"},{"key":"e_1_2_13_118_1","doi-asserted-by":"publisher","DOI":"10.1093\/sleep\/9.1.260"},{"key":"e_1_2_13_119_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.sleep.2016.01.024"},{"key":"e_1_2_13_120_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1389-9457(99)00014-3"},{"key":"e_1_2_13_121_1","doi-asserted-by":"publisher","DOI":"10.1089\/cap.2008.036"},{"key":"e_1_2_13_122_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pediatrneurol.2018.10.020"},{"key":"e_1_2_13_123_1","doi-asserted-by":"publisher","DOI":"10.1093\/sleep\/16.5.444"},{"key":"e_1_2_13_124_1","doi-asserted-by":"publisher","DOI":"10.1093\/sleep\/29.8.1025"},{"key":"e_1_2_13_125_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.sleep.2018.05.037"},{"key":"e_1_2_13_126_1","doi-asserted-by":"publisher","DOI":"10.1155\/2019\/6537815"},{"key":"e_1_2_13_127_1","doi-asserted-by":"publisher","DOI":"10.1176\/jnp.2010.22.3.352.e26"},{"key":"e_1_2_13_128_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.36.6.1076"},{"key":"e_1_2_13_129_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(79)92495-4"},{"key":"e_1_2_13_130_1","doi-asserted-by":"publisher","DOI":"10.1177\/030006057300100530"},{"key":"e_1_2_13_131_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-1331.2011.03610.x"},{"key":"e_1_2_13_132_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00415-008-0983-7"},{"key":"e_1_2_13_133_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2352-4642(18)30133-0"},{"key":"e_1_2_13_134_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11325-011-0520-2"},{"key":"e_1_2_13_135_1","doi-asserted-by":"publisher","DOI":"10.1159\/000324549"},{"key":"e_1_2_13_136_1","doi-asserted-by":"publisher","DOI":"10.1111\/ced.13282"},{"key":"e_1_2_13_137_1","doi-asserted-by":"publisher","DOI":"10.5664\/jcsm.3284"},{"key":"e_1_2_13_138_1","first-page":"362","article-title":"REM changes in narcolepsy with selegiline","volume":"18","author":"Reinish LW","year":"1995","journal-title":"Sleep"},{"key":"e_1_2_13_139_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.sleep.2008.04.004"},{"key":"e_1_2_13_140_1","doi-asserted-by":"publisher","DOI":"10.1093\/sleep\/9.1.194"},{"key":"e_1_2_13_141_1","doi-asserted-by":"publisher","DOI":"10.1093\/sleep\/24.4.385"},{"key":"e_1_2_13_142_1","doi-asserted-by":"publisher","DOI":"10.1097\/00006199-199303000-00009"},{"key":"e_1_2_13_143_1","doi-asserted-by":"publisher","DOI":"10.1111\/jsr.12468"},{"key":"e_1_2_13_144_1","doi-asserted-by":"publisher","DOI":"10.5665\/sleep.5968"},{"key":"e_1_2_13_145_1","doi-asserted-by":"publisher","DOI":"10.1155\/2018\/1671072"},{"key":"e_1_2_13_146_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1520-6394(1998)7:2<92::AID-DA9>3.0.CO;2-7"},{"key":"e_1_2_13_147_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00406-004-0530-1"},{"key":"e_1_2_13_148_1","first-page":"22","article-title":"Improvement in cataplexy and daytime somnolence in narcoleptic patients with venlafaxine XR administration","volume":"4","author":"Salin\u2010Pascual RJ","year":"2002","journal-title":"Sleep Hypnosis"},{"key":"e_1_2_13_149_1","first-page":"14","article-title":"A case of modafinil induced mania in a child suffering from narcolepsy","volume":"8","author":"Sanyal D","year":"2017","journal-title":"Bengal J Private Psychiatry"},{"key":"e_1_2_13_150_1","doi-asserted-by":"publisher","DOI":"10.1097\/NRL.0000000000000099"},{"key":"e_1_2_13_151_1","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2014.00136"},{"key":"e_1_2_13_152_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.43.2.171"},{"key":"e_1_2_13_153_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0404.1986.tb03518.x"},{"key":"e_1_2_13_154_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-3223(89)90048-6"},{"key":"e_1_2_13_155_1","doi-asserted-by":"publisher","DOI":"10.1093\/sleep\/13.6.479"},{"key":"e_1_2_13_156_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.290.6476.1167"},{"key":"e_1_2_13_157_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(16)30333-7"},{"key":"e_1_2_13_158_1","doi-asserted-by":"publisher","DOI":"10.1111\/jsr.12627"},{"key":"e_1_2_13_159_1","first-page":"42","article-title":"A randomized, double blind, placebo\u2010controlled multicenter trial comparing the effects of three doses of orally administered sodium oxybate with placebo for the treatment of narcolepsy","volume":"25","author":"The U.S. Xyrem Multicenter Study Group","year":"2002","journal-title":"Sleep"},{"key":"e_1_2_13_160_1","doi-asserted-by":"publisher","DOI":"10.5664\/jcsm.26368"},{"key":"e_1_2_13_161_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.25423"},{"key":"e_1_2_13_162_1","doi-asserted-by":"publisher","DOI":"10.1093\/sleep\/15.3.212"},{"key":"e_1_2_13_163_1","first-page":"31","article-title":"A 12\u2010month, open\u2010label, multicenter extension trial of orally administered sodium oxybate for the treatment of narcolepsy","volume":"26","author":"US Xyrem Multicenter Study Group","year":"2003","journal-title":"Sleep"},{"key":"e_1_2_13_164_1","doi-asserted-by":"publisher","DOI":"10.1016\/0013-4694(94)90071-X"},{"key":"e_1_2_13_165_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410430115"},{"key":"e_1_2_13_166_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.54.5.1166"},{"key":"e_1_2_13_167_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00415-008-0996-2"},{"key":"e_1_2_13_168_1","doi-asserted-by":"publisher","DOI":"10.1212\/NXI.0000000000000389"},{"key":"e_1_2_13_169_1","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.162.4.813-a"},{"key":"e_1_2_13_170_1","doi-asserted-by":"publisher","DOI":"10.5664\/jcsm.2848"},{"key":"e_1_2_13_171_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbr.2013.12.045"},{"key":"e_1_2_13_172_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1445-5994.2008.01710.x"},{"key":"e_1_2_13_173_1","doi-asserted-by":"publisher","DOI":"10.1097\/JCP.0b013e3181accefe"},{"key":"e_1_2_13_174_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.sleep.2009.01.005"}],"container-title":["European Journal of Neurology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ene.14888","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/ene.14888","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ene.14888","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,25]],"date-time":"2023-08-25T17:59:15Z","timestamp":1692986355000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/ene.14888"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,6,25]]},"references-count":173,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2021,9]]}},"alternative-id":["10.1111\/ene.14888"],"URL":"https:\/\/doi.org\/10.1111\/ene.14888","archive":["Portico"],"relation":{},"ISSN":["1351-5101","1468-1331"],"issn-type":[{"value":"1351-5101","type":"print"},{"value":"1468-1331","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,6,25]]},"assertion":[{"value":"2021-03-07","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-04-20","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-06-25","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}