{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T17:54:54Z","timestamp":1790704494620,"version":"4.1.0"},"reference-count":26,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2021,6,16]],"date-time":"2021-06-16T00:00:00Z","timestamp":1623801600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Euro J of Neurology"],"published-print":{"date-parts":[[2021,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and purpose<\/jats:title><jats:p>The efficacy of patent foramen ovale (PFO) closure to reduce the frequency of migraine attacks remains controversial.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This was a planned sub\u2010study in migraine patients enrolled in a randomized, clinical trial designed to assess the superiority of PFO closure plus antiplatelet therapy over antiplatelet therapy alone to prevent stroke recurrence in patients younger than 60\u00a0years with a PFO\u2010associated cryptogenic ischaemic stroke. The main outcome was the mean annual number of migraine attacks in migraine patients with aura and in those without aura, as recorded at each follow\u2010up visit by study neurologists.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of 473 patients randomized to PFO closure or antiplatelet therapy, 145 (mean age 41.9\u00a0years; women 58.6%) had migraine (75 with aura and 70 without aura). Sixty\u2010seven patients were randomized to PFO closure and 78 to antiplatelet therapy. During a mean follow\u2010up of about 5\u00a0years, there were no differences between antiplatelet\u2010only and PFO closure groups in the mean annual number of migraine attacks, both in migraine patients with aura (9.2 [11.9] vs. 12.0 [19.1], <jats:italic>p<\/jats:italic>\u00a0=\u00a00.81) and in those without aura (12.1 [16.1] vs. 11.8 [18.4], <jats:italic>p<\/jats:italic>\u00a0&gt;\u00a00.999). There were no differences between treatment groups regarding cessation of migraine attacks, migraine\u2010related disability at 2\u00a0years and use of migraine\u2010preventive drugs during follow\u2010up.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>In young and middle\u2010aged adults with PFO\u2010associated cryptogenic stroke and migraine, PFO closure plus antiplatelet therapy did not reduce the mean annual number of migraine attacks compared to antiplatelet therapy alone, in migraine patients both with and without aura.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ene.14892","type":"journal-article","created":{"date-parts":[[2021,5,3]],"date-time":"2021-05-03T09:00:18Z","timestamp":1620032418000},"page":"2700-2707","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":24,"title":["Patent foramen ovale closure in stroke patients with migraine in the CLOSE trial. The CLOSE\u2010MIG study"],"prefix":"10.1111","volume":"28","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4891-3127","authenticated-orcid":false,"given":"Jean\u2010Louis","family":"Mas","sequence":"first","affiliation":[{"name":"Stroke Unit Department of Neurology Sainte\u2010Anne Hospital Paris Descartes University INSERM 1226 Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beno\u00eet","family":"Guillon","sequence":"additional","affiliation":[{"name":"Stroke Unit Department of Neurology University Hospital of Nantes Nantes France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana\u00efs","family":"Charles\u2010Nelson","sequence":"additional","affiliation":[{"name":"Assistance Publique\u2014H\u00f4pitaux de Paris (AP\u2010HP) H\u00f4pital Europ\u00e9en Georges\u2014Pompidou Unit\u00e9 de Recherche Clinique Centre d\u2019Investigations Cliniques 1418 (CIC1418) Paris 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