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Recent data suggest an increased risk of myocardial infarction and stroke in PD patients. Therefore, we designed a study to assess surrogate markers of cardiovascular and cerebrovascular risk in PD.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We conducted a case\u2212control study comparing PD patients recruited from a Movement Disorders Unit with controls randomly invited from a primary healthcare center. All participants underwent a detailed clinical evaluation, including medical history, physical assessment, carotid ultrasound, blood and urine analysis, and 24\u2010h ambulatory blood pressure monitoring. The primary outcome was the carotid intima\u2010media thickness (CIMT).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We included 102 participants in each study arm. No significant difference was found in the CIMT among groups (MD: 0.01, 95% CI: \u22120.02, 0.04). Carotid plaques were more frequent in PD patients (OR: 1.90, 95% CI: 1.02, 3.55), although the lipid profile was more favorable in this group (LDL MD: \u221218.75; 95% CI: \u221210.69, \u221226.81). Nocturnal systolic blood pressure was significantly higher in PD patients (MD: 4.37, 95% CI: 0.27, 8.47) and more than half of the PD patients were non\u2010dippers or reverse dippers (OR: 1.83, 95% CI: 1.04, 3.20).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>We did not find a difference in CIMT between PD and controls. A higher frequency of carotid plaques and abnormal dipper profile supports the hypothesis that PD patients are not protected from cardiovascular and cerebrovascular disease.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ene.14938","type":"journal-article","created":{"date-parts":[[2021,5,25]],"date-time":"2021-05-25T15:40:23Z","timestamp":1621957223000},"page":"2669-2679","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Cardiovascular and cerebrovascular risk markers in Parkinson\u2019s disease: Results from a case\u2212control study"],"prefix":"10.1111","volume":"28","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1369-8423","authenticated-orcid":false,"given":"Mariana","family":"Alves","sequence":"first","affiliation":[{"name":"Servi\u00e7o de Medicina III Hospital Pulido Valente CHULN Lisboa Portugal"},{"name":"Laboratory of Clinical Pharmacology and Therapeutics Faculdade de Medicina Universidade de Lisboa Lisboa Portugal"},{"name":"Instituto de Medicina Molecular Jo\u00e3o Lobo Antunes Faculdade de Medicina Universidade de Lisboa Lisboa Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patr\u00edcia","family":"Pita Lobo","sequence":"additional","affiliation":[{"name":"Servi\u00e7o de Neurologia Departamento de Neuroci\u00eancias e Sa\u00fade Mental CHULN Lisboa Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8463-5625","authenticated-orcid":false,"given":"Linda Azevedo","family":"Kauppila","sequence":"additional","affiliation":[{"name":"Servi\u00e7o de Neurologia Departamento de Neuroci\u00eancias e Sa\u00fade Mental CHULN Lisboa Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1413-0343","authenticated-orcid":false,"given":"Leonor","family":"Rebord\u00e3o","sequence":"additional","affiliation":[{"name":"Servi\u00e7o de Neurologia Hospital Fernando da Fonseca Lisboa Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. 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