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Ghrelin and ghrelin receptor (ghrelin\u2010R) agonists were previously found to exert anticonvulsant, neuroprotective and anti\u2010inflammatory effects in seizure models and immediately after status epilepticus (SE). Therefore, the aim of this study was to assess whether the ghrelin\u2010R agonist macimorelin is antiepileptogenic in the pharmacoresistant intrahippocampal kainic acid (IHKA) mouse model.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>SE was induced in C57BL\/6\u00a0mice by unilateral IHKA injection. Starting 24\u00a0h after SE, mice were treated intraperitoneally with macimorelin (5\u00a0mg\/kg) or saline twice daily for 2\u00a0weeks, followed by a 2\u2010week wash\u2010out. Mice were continuously electroencephalogram\u2010monitored, and at the end of the experiment neuroprotection and gliosis were assessed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Macimorelin significantly decreased the number and duration of seizures during the treatment period, but had no antiepileptogenic or disease\u2010modifying effect in this dose regimen. While macimorelin did not significantly affect food intake or body weight over a 2\u2010week treatment period, its acute orexigenic effect was preserved in epileptic mice but not in sham mice.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>While the full ghrelin\u2010R agonist macimorelin was not significantly antiepileptogenic nor disease\u2010modifying, this is the first study to demonstrate its anticonvulsant effects in the IHKA model of drug\u2010refractory temporal lobe epilepsy. 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