{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T00:06:54Z","timestamp":1789776414016,"version":"4.0.1"},"reference-count":41,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2021,7,30]],"date-time":"2021-07-30T00:00:00Z","timestamp":1627603200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Euro J of Neurology"],"published-print":{"date-parts":[[2022,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and purpose<\/jats:title><jats:p>Consensus criteria for autoimmune limbic encephalitis (ALE) allow for a diagnosis even without neuronal antibodies (Abs), but it remains unclear which clinical features should prompt neuronal Ab screening in temporal lobe epilepsy patients. The aim of the study was to investigate whether patients with temporal lobe seizures associated with additional symptoms or signs of limbic involvement may harbor neuronal Abs, and which clinical features should prompt neuronal Ab screening in these patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We identified 47 patients from a tertiary epilepsy center with mediotemporal lobe seizures and additional features suggestive of limbic involvement, including either memory deficits, psychiatric symptoms, mediotemporal magnetic resonance imaging (MRI) hyperintensities or inflammatory cerebrospinal fluid (CSF). Neuronal Ab testing was carried out at two independent reference laboratories (Bielefeld\u2010Bethel, Germany, and Barcelona, Spain). All brain MRI scans were assessed by two reviewers independently.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Temporal lobe seizures were accompanied by memory deficits in 35\/46 (76%), psychiatric symptoms in 27\/42 (64%), and both in 19\/42 patients (45%). Limbic T2\/fluid\u2010attenuated inversion recovery signal hyperintensities were found in 26\/46 patients (57%; unilateral: <jats:italic>n<\/jats:italic>\u00a0=\u00a022, bilateral: <jats:italic>n<\/jats:italic>\u00a0=\u00a04). Standard CSF studies were abnormal in 2\/37 patients (5%). Neuronal Abs were confirmed in serum and\/or CSF in 8\/47 patients (17%) and were directed against neuronal cell\u2010surface targets (leucine\u2010rich glioma inactivated protein 1: <jats:italic>n<\/jats:italic>\u00a0=\u00a01, contactin\u2010associated protein\u20102: <jats:italic>n<\/jats:italic>\u00a0=\u00a01, undetermined target: <jats:italic>n<\/jats:italic>\u00a0=\u00a03) or glutamic acid decarboxylase in its 65\u2010kD isoform (<jats:italic>n<\/jats:italic>\u00a0=\u00a03, all with high titers). Compared to Ab\u2010negative patients, those who harbored neuronal Abs were more likely to have uni\u2010 or bilateral mediotemporal MRI changes (8\/8, 100% vs. 18\/38, 47%; <jats:italic>p<\/jats:italic>\u00a0=\u00a00.01, Fisher's exact test).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>In patients with temporal lobe seizures and additional limbic signs, 17% had neuronal Abs affirming ALE diagnosis. Mediotemporal MRI changes were found in all Ab\u2010positive cases and had a positive likelihood ratio of 2.11 (95% confidence interval 1.51\u20132.95).<\/jats:p><\/jats:sec>","DOI":"10.1111\/ene.15026","type":"journal-article","created":{"date-parts":[[2021,7,20]],"date-time":"2021-07-20T08:47:58Z","timestamp":1626770878000},"page":"1303-1310","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Diagnostic challenges in patients with temporal lobe seizures and features of autoimmune limbic encephalitis"],"prefix":"10.1111","volume":"29","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3930-8056","authenticated-orcid":false,"given":"Fatme Seval","family":"Ismail","sequence":"first","affiliation":[{"name":"Department of Neurology University Hospital Knappschaftskrankenhaus Bochum  Bochum 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