{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T23:59:35Z","timestamp":1792886375144,"version":"4.5.0"},"reference-count":45,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2021,8,4]],"date-time":"2021-08-04T00:00:00Z","timestamp":1628035200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100009553","name":"Agentura Pro Zdravotnick\u00fd V\u00fdzkum \u010cesk\u00e9 Republiky","doi-asserted-by":"publisher","award":["NV18\u201004\u201000159"],"award-info":[{"award-number":["NV18\u201004\u201000159"]}],"id":[{"id":"10.13039\/501100009553","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003243","name":"Ministerstvo Zdravotnictv\u00ed Cesk\u00e9 Republiky","doi-asserted-by":"publisher","award":["65269705"],"award-info":[{"award-number":["65269705"]}],"id":[{"id":"10.13039\/501100003243","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["P41 EB027061"],"award-info":[{"award-number":["P41 EB027061"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["P30 NS076408"],"award-info":[{"award-number":["P30 NS076408"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000038","name":"Natural Sciences and Engineering Research Council of Canada","doi-asserted-by":"publisher","award":["RGPIN\u20102019\u201007244"],"award-info":[{"award-number":["RGPIN\u20102019\u201007244"]}],"id":[{"id":"10.13039\/501100000038","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Euro J of Neurology"],"published-print":{"date-parts":[[2021,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and purpose<\/jats:title><jats:p>Non\u2010myelopathic degenerative cervical spinal cord compression (NMDC) frequently occurs throughout aging and may progress to potentially irreversible degenerative cervical myelopathy (DCM). Whereas standard clinical magnetic resonance imaging (MRI) and electrophysiological measures assess compression severity and neurological dysfunction, respectively, underlying microstructural deficits still have to be established in NMDC and DCM patients. The study aims to establish tract\u2010specific diffusion MRI markers of electrophysiological deficits to predict the progression of asymptomatic NMDC to symptomatic DCM.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>High\u2010resolution 3 T diffusion MRI was acquired for 103 NMDC and 21 DCM patients compared to 60 healthy controls to reveal diffusion alterations and relationships between tract\u2010specific diffusion metrics and corresponding electrophysiological measures and compression severity. Relationship between the degree of DCM disability, assessed by the modified Japanese Orthopaedic Association scale, and tract\u2010specific microstructural changes in DCM patients was also explored.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The study identified diffusion\u2010derived abnormalities in the gray matter, dorsal and lateral tracts congruent with trans\u2010synaptic degeneration and demyelination in chronic degenerative spinal cord compression with more profound alterations in DCM than NMDC. Diffusion metrics were affected in the C3\u20106 area as well as above the compression level at C3 with more profound rostral deficits in DCM than NMDC. Alterations in lateral motor and dorsal sensory tracts correlated with motor and sensory evoked potentials, respectively, whereas electromyography outcomes corresponded with gray matter microstructure. DCM disability corresponded with microstructure alteration in lateral columns.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Outcomes imply the necessity of high\u2010resolution tract\u2010specific diffusion MRI for monitoring degenerative spinal pathology in longitudinal studies.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ene.15027","type":"journal-article","created":{"date-parts":[[2021,7,21]],"date-time":"2021-07-21T09:02:17Z","timestamp":1626858137000},"page":"3784-3797","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":29,"title":["Diffusion magnetic resonance imaging reveals tract\u2010specific microstructural correlates of electrophysiological impairments in non\u2010myelopathic and myelopathic spinal cord compression"],"prefix":"10.1111","volume":"28","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7398-4990","authenticated-orcid":false,"given":"Jan","family":"Valo\u0161ek","sequence":"first","affiliation":[{"name":"Department of Neurology Faculty of Medicine and Dentistry Palack\u00fd University Olomouc Czechia"},{"name":"Department of Biomedical Engineering University Hospital Olomouc Czechia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0439-1304","authenticated-orcid":false,"given":"Ren\u00e9","family":"Labounek","sequence":"additional","affiliation":[{"name":"Department of Neurology Faculty of Medicine and Dentistry Palack\u00fd University Olomouc Czechia"},{"name":"Division of Clinical Behavioral Neuroscience Department of Pediatrics University of Minnesota Minneapolis Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1743-1133","authenticated-orcid":false,"given":"Tom\u00e1\u0161","family":"Hor\u00e1k","sequence":"additional","affiliation":[{"name":"Central European Institute of Technology Masaryk University Brno Czechia"},{"name":"Department of Neurology University Hospital Brno Brno Czechia"},{"name":"Faculty of Medicine Masaryk University Brno Czechia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3317-2661","authenticated-orcid":false,"given":"Magda","family":"Hor\u00e1kov\u00e1","sequence":"additional","affiliation":[{"name":"Department of Neurology University Hospital Brno Brno Czechia"},{"name":"Faculty of Medicine Masaryk University Brno Czechia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8828-7661","authenticated-orcid":false,"given":"Petr","family":"Bedna\u0159\u00edk","sequence":"additional","affiliation":[{"name":"Central European Institute of Technology Masaryk University Brno Czechia"},{"name":"High Field MR Centre Department of Biomedical Imaging and Image\u2010guided Therapy Medical University of Vienna Vienna Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0587-9897","authenticated-orcid":false,"given":"Milo\u0161","family":"Ke\u0159kovsk\u00fd","sequence":"additional","affiliation":[{"name":"Faculty of Medicine Masaryk University Brno Czechia"},{"name":"Department of Radiology and Nuclear Medicine University Hospital Brno Brno Czechia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2937-6373","authenticated-orcid":false,"given":"Jan","family":"Ko\u010dica","sequence":"additional","affiliation":[{"name":"Department of Neurology University Hospital Brno Brno Czechia"},{"name":"Faculty of Medicine Masaryk University Brno Czechia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7105-583X","authenticated-orcid":false,"given":"Tom\u00e1\u0161","family":"Rohan","sequence":"additional","affiliation":[{"name":"Faculty of Medicine Masaryk University Brno Czechia"},{"name":"Department of Radiology and Nuclear Medicine University Hospital Brno Brno Czechia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4646-3185","authenticated-orcid":false,"given":"Christophe","family":"Lenglet","sequence":"additional","affiliation":[{"name":"Center for Magnetic Resonance Research Department of Radiology University of Minnesota Minneapolis Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3662-9532","authenticated-orcid":false,"given":"Julien","family":"Cohen\u2010Adad","sequence":"additional","affiliation":[{"name":"NeuroPoly Lab Institute of Biomedical Engineering Polytechnique Montreal Montreal Quebec Canada"},{"name":"Functional Neuroimaging Unit CRIUGM University of Montreal Montreal Quebec Canada"},{"name":"Mila \u2010 Quebec AI Institute Montreal Quebec Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1951-0671","authenticated-orcid":false,"given":"Petr","family":"Hlu\u0161t\u00edk","sequence":"additional","affiliation":[{"name":"Department of Neurology Faculty of Medicine and Dentistry Palack\u00fd University Olomouc Czechia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2322-5539","authenticated-orcid":false,"given":"Eva","family":"Vl\u010dkov\u00e1","sequence":"additional","affiliation":[{"name":"Department of Neurology University Hospital Brno Brno Czechia"},{"name":"Faculty of Medicine Masaryk University Brno Czechia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5146-2457","authenticated-orcid":false,"suffix":"Jr.","given":"Zden\u011bk","family":"Kada\u0148ka","sequence":"additional","affiliation":[{"name":"Department of Neurology University Hospital Brno Brno Czechia"},{"name":"Faculty of Medicine Masaryk University Brno Czechia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7420-2383","authenticated-orcid":false,"given":"Josef","family":"Bedna\u0159\u00edk","sequence":"additional","affiliation":[{"name":"Central European Institute of Technology Masaryk University Brno Czechia"},{"name":"Department of Neurology University Hospital Brno Brno Czechia"},{"name":"Faculty of Medicine Masaryk University Brno Czechia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9188-4280","authenticated-orcid":false,"given":"Alena","family":"Svatkova","sequence":"additional","affiliation":[{"name":"Central European Institute of Technology Masaryk University Brno Czechia"},{"name":"Department of Medicine III Clinical Division of Endocrinology and Metabolism Medical University of Vienna Vienna Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,8,4]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41582-019-0303-0"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00586-008-0585-1"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1177\/2192568220934496"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/BRS.0000000000001842"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00586-015-4049-0"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/brb3.797"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.brs.0000142434.02579.84"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1177\/2192568217745519"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/BRS.0b013e3182a7f2e7"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.3174\/ajnr.A5162"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00586-018-5579-z"},{"key":"e_1_2_9_13_1","first-page":"65","article-title":"Diffusion tensor imaging in cervical spondylotic myelopathy: a review","volume":"33","author":"Shabani S","year":"2020","journal-title":"J Neurosurg Spine"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41582-019-0270-5"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1089\/neu.2019.6694"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0195733"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2017-019809"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/jon.12372"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1097\/BRS.0b013e31820e6c35"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-3495(94)80775-1"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2011.09.081"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-020-70297-3"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.10609"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2018.09.081"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2017.10.041"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2015.06.040"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2016.10.009"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/76.1.70"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00586-016-4660-8"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1007\/s005860050113"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.24736"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2011.09.015"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1155\/2014\/719520"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2018.04.009"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41582-019-0303-0"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.spinee.2006.04.024"},{"key":"e_1_2_9_37_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00256-011-1161-z"},{"key":"e_1_2_9_38_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00330-015-3876-z"},{"key":"e_1_2_9_39_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.13121885"},{"key":"e_1_2_9_40_1","first-page":"1587","article-title":"MR diffusion tensor imaging and fiber tracking in spinal cord compression","volume":"26","author":"Facon D","year":"2005","journal-title":"AJNR Am J Neuroradiol"},{"key":"e_1_2_9_41_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep24636"},{"key":"e_1_2_9_42_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00330-010-1927-z"},{"key":"e_1_2_9_43_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awr328"},{"key":"e_1_2_9_44_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00330-019-06352-z"},{"key":"e_1_2_9_45_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep09975"},{"key":"e_1_2_9_46_1","unstructured":"Cohen\u2010AdadJ Wheeler\u2010KingshottC.Quantitative MRI of the Spinal Cord.San Diego CA:Academic Press (Elsevier); 2014."}],"updated-by":[{"DOI":"10.1111\/ene.15352","type":"correction","label":"Correction","source":"publisher","updated":{"date-parts":[[2022,7,15]],"date-time":"2022-07-15T00:00:00Z","timestamp":1657843200000}}],"container-title":["European Journal of Neurology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ene.15027","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/ene.15027","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ene.15027","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,25]],"date-time":"2023-08-25T16:53:17Z","timestamp":1692982397000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/ene.15027"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,8,4]]},"references-count":45,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2021,11]]}},"alternative-id":["10.1111\/ene.15027"],"URL":"https:\/\/doi.org\/10.1111\/ene.15027","archive":["Portico"],"relation":{"correction":[{"id-type":"doi","id":"10.1111\/ene.15352","asserted-by":"object"}]},"ISSN":["1351-5101","1468-1331"],"issn-type":[{"value":"1351-5101","type":"print"},{"value":"1468-1331","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,8,4]]},"assertion":[{"value":"2021-06-15","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-07-16","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-08-04","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}