{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,14]],"date-time":"2025-10-14T20:17:57Z","timestamp":1760473077687,"version":"3.40.5"},"reference-count":33,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2021,8,31]],"date-time":"2021-08-31T00:00:00Z","timestamp":1630368000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Euro J of Neurology"],"published-print":{"date-parts":[[2022,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and purpose<\/jats:title><jats:p>Fibroblast growth factor 23 (FGF23) is an osteogenic hormone associated with chronic kidney disease and is an emerging risk factor for several cardiovascular diseases. The association of FGF23 with stroke is unclear. The aim of this study was to investigate the association of FGF23 with incident intracerebral hemorrhage (ICH).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This was a nested case\u2013control study of 220 ICH cases and 244 age\u2010 and sex\u2010matched controls from the population\u2010based Malm\u00f6 Diet and Cancer Study (<jats:italic>n<\/jats:italic>\u00a0=\u00a028,449). Incident ICH cases were ascertained using national registers and classified by bleeding location. Logistic regression was used to study the association of plasma levels of FGF23 with incident ICH, adjusting for potential ICH risk factors. Subgroup analyses were performed for lobar and non\u2010lobar ICH, fatal ICH, ICH with large volume and ICH with poor functional outcome, respectively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Higher FGF23 levels at baseline were significantly associated with incident ICH. After multivariable adjustment, the odds ratio for the association with all ICH was 1.84 (95% confidence interval [CI] 1.25\u20132.71, <jats:italic>p<\/jats:italic>\u00a0=\u00a00.002) per doubling of FGF23 concentration. For lobar and non\u2010lobar ICH, odds ratios were 1.73 (95% CI 1.04\u20132.87, <jats:italic>p<\/jats:italic>\u00a0=\u00a00.035) and 2.13 (95% CI 1.32\u20133.45, <jats:italic>p<\/jats:italic>\u00a0=\u00a00.002), respectively. FGF23 was also significantly associated with fatal ICH, ICH with large volume and ICH with poor functional outcome.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Higher FGF23 was associated with incident ICH in this nested case\u2013control study. Further studies are required to explore whether the association is causal.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ene.15060","type":"journal-article","created":{"date-parts":[[2021,8,11]],"date-time":"2021-08-11T17:32:34Z","timestamp":1628703154000},"page":"114-120","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Fibroblast growth factor 23 is associated with risk of intracerebral hemorrhage"],"prefix":"10.1111","volume":"29","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7720-3701","authenticated-orcid":false,"given":"Edith H.","family":"Svensson","sequence":"first","affiliation":[{"name":"Department of Clinical Sciences Malm\u00f6 Lund University Lund Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martin","family":"S\u00f6derholm","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences Malm\u00f6 Lund University Lund Sweden"},{"name":"Department of Neurology 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