{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,4]],"date-time":"2026-03-04T17:04:24Z","timestamp":1772643864771,"version":"3.50.1"},"reference-count":47,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2021,9,3]],"date-time":"2021-09-03T00:00:00Z","timestamp":1630627200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Euro J of Neurology"],"published-print":{"date-parts":[[2021,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and purpose<\/jats:title><jats:p>During acute coronavirus disease 2019 (COVID\u201019) infection, neurological signs, symptoms and complications occur. We aimed to assess their clinical relevance by evaluating real\u2010world data from a multinational registry.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We analyzed COVID\u201019 patients from 127 centers, diagnosed between January 2020 and February 2021, and registered in the European multinational LEOSS (Lean European Open Survey on SARS\u2010Infected Patients) registry. The effects of prior neurological diseases and the effect of neurological symptoms on outcome were studied using multivariate logistic regression.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 6537 COVID\u201019 patients (97.7% PCR\u2010confirmed) were analyzed, of whom 92.1% were hospitalized and 14.7% died. Commonly, excessive tiredness (28.0%), headache (18.5%), nausea\/emesis (16.6%), muscular weakness (17.0%), impaired sense of smell (9.0%) and taste (12.8%), and delirium (6.7%) were reported. In patients with a complicated or critical disease course (53%) the most frequent neurological complications were ischemic stroke (1.0%) and intracerebral bleeding (ICB; 2.2%). ICB peaked in the critical disease phase (5%) and was associated with the administration of anticoagulation and extracorporeal membrane oxygenation (ECMO). Excessive tiredness (odds ratio [OR] 1.42, 95% confidence interval [CI] 1.20\u20131.68) and prior neurodegenerative diseases (OR 1.32, 95% CI 1.07\u20131.63) were associated with an increased risk of an unfavorable outcome. Prior cerebrovascular and neuroimmunological diseases were not associated with an unfavorable short\u2010term outcome of COVID\u201019.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Our data on mostly hospitalized COVID\u201019 patients show that excessive tiredness or prior neurodegenerative disease at first presentation increase the risk of an unfavorable short\u2010term outcome. ICB in critical COVID\u201019 was associated with therapeutic interventions, such as anticoagulation and ECMO, and thus may be an indirect complication of a life\u2010threatening systemic viral infection.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ene.15072","type":"journal-article","created":{"date-parts":[[2021,8,19]],"date-time":"2021-08-19T19:57:07Z","timestamp":1629403027000},"page":"3925-3937","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":29,"title":["Neurological symptoms and complications in predominantly hospitalized COVID\u201019 patients: Results of the European multinational Lean European Open Survey on SARS\u2010Infected Patients (LEOSS)"],"prefix":"10.1111","volume":"28","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2582-878X","authenticated-orcid":false,"given":"Nina N.","family":"Kleineberg","sequence":"first","affiliation":[{"name":"Department of Neurology Faculty of Medicine and University Hospital Cologne University of Cologne Cologne Germany"},{"name":"Cognitive Neuroscience Institute of Neuroscience and Medicine (INM\u20103) Research Centre J\u00fclich J\u00fclich Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Samuel","family":"Knauss","sequence":"additional","affiliation":[{"name":"Department of Neurology with Experimental Neurology Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin Corporate Member of Freie Universit\u00e4t Berlin and Humboldt Universit\u00e4t zu Berlin Berlin Germany"},{"name":"DZHK (German Centre for Cardiovascular Research), Partner Site Berlin Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eileen","family":"G\u00fclke","sequence":"additional","affiliation":[{"name":"Department of Neurology University Medical Center Hamburg\u2010Eppendorf Hamburg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hans O.","family":"Pinnschmidt","sequence":"additional","affiliation":[{"name":"Institute of Medical Biometry Epidemiology University Medical Centre Hamburg\u2010Eppendorf Hamburg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carolin E. 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