{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T02:11:07Z","timestamp":1790043067258,"version":"4.0.1"},"reference-count":19,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2021,9,28]],"date-time":"2021-09-28T00:00:00Z","timestamp":1632787200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Euro J of Neurology"],"published-print":{"date-parts":[[2022,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and purpose<\/jats:title><jats:p>Many migraine patients rely on over\u2010the\u2010counter analgesics for the treatment of migraine attacks. Fixed\u2010dose combinations of aspirin, paracetamol and caffeine (APC) have been used for treating migraine in many countries for a long time. We performed a meta\u2010analysis for the comparison of APC versus placebo, which has not been done to date.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Randomized, blinded, placebo\u2010controlled, parallel\u2010group studies using APC to treat a migraine attack were included in a meta\u2010analysis. We calculated the rate ratio (RRs) associated with APC versus placebo.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Seven studies were included, with 3306 participants (2147 treated with APC and 1159 treated with placebo). For the primary efficacy outcome, being pain\u2010free at 2\u00a0h, APC was superior to placebo (19.6% vs. 9.0%, RR\u00a02.2, 95% confidence interval [CI] 1.4\u20133.3). For the co\u2010primary efficacy outcome, pain relief at 2\u00a0h, APC was superior to placebo (54.3% vs. 31.2%, RR 1.7, 95% CI 1.6\u20131.9). Adverse events were more frequent in the APC than the placebo groups (10.9% vs. 7.8%, RR\u00a01.7, 95% CI 1.3\u20132.2).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Results showed that APC is superior to placebo in the treatment of acute migraine attacks. Efficacy, measured by pain\u2010free response and pain relief at 2\u00a0h, was clinically relevant.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ene.15103","type":"journal-article","created":{"date-parts":[[2021,9,14]],"date-time":"2021-09-14T08:03:42Z","timestamp":1631606622000},"page":"350-357","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":32,"title":["Aspirin, paracetamol (acetaminophen) and caffeine for the treatment of acute migraine attacks: A systemic review and meta\u2010analysis of randomized placebo\u2010controlled trials"],"prefix":"10.1111","volume":"29","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6556-8612","authenticated-orcid":false,"given":"Hans Christoph","family":"Diener","sequence":"first","affiliation":[{"name":"Institute for Medical Informatics, Biometry and Epidemiology Medical Faculty of the University of Duisburg\u2010Essen Essen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9362-3711","authenticated-orcid":false,"given":"Charly","family":"Gaul","sequence":"additional","affiliation":[{"name":"Migraine and Headache Clinic Koenigstein Koenigstein Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1672-9309","authenticated-orcid":false,"given":"Walter","family":"Lehmacher","sequence":"additional","affiliation":[{"name":"Institute for Medical Statistics Informatics and Epidemiology University of Cologne Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1556-7715","authenticated-orcid":false,"given":"Thomas","family":"Weiser","sequence":"additional","affiliation":[{"name":"Sanofi Deutschland CHC Medical Affairs Frankfurt Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,9,28]]},"reference":[{"issue":"4","key":"e_1_2_8_2_1","first-page":"CD008041","article-title":"Aspirin for acute migraine headaches in adults","volume":"2013","author":"Kirthi V","year":"2013","journal-title":"Cochrane Database Syst Rev"},{"issue":"4","key":"e_1_2_8_3_1","first-page":"CD008040","article-title":"Paracetamol (acetaminophen) with or without an antiemetic for acute migraine headaches in adults","volume":"2013","author":"Derry S","year":"2013","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1177\/0333102411417901"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1177\/0333102419828967"},{"issue":"12","key":"e_1_2_8_6_1","first-page":"CD009281","article-title":"Caffeine as an analgesic adjuvant for acute pain in adults","author":"Derry CJ","year":"2014","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_2_8_7_1","first-page":"CD007887","article-title":"Drug therapy for treating post\u2010dural puncture headache","volume":"7","author":"Basurto OX","year":"2015","journal-title":"Cochrane Database of Syst Rev"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-2982.2005.00948.x"},{"key":"e_1_2_8_9_1","unstructured":"https:\/\/www.accessdata.fda.gov\/drugsatfda_docs\/nda\/98\/020802_s000_AP_LTR.pdf; 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