{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T11:39:24Z","timestamp":1791545964577,"version":"4.3.4"},"reference-count":31,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2021,10,5]],"date-time":"2021-10-05T00:00:00Z","timestamp":1633392000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Euro J of Neurology"],"published-print":{"date-parts":[[2022,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and purpose<\/jats:title><jats:p>Real\u2010world data on alemtuzumab are limited and do not provide evidence of its effectiveness after various disease\u2010modifying therapies (DMTs). Our aim was to provide real\u2010world data on the impact of clinical variables and previous DMTs on clinical response to alemtuzumab.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Sixteen Italian multiple sclerosis centers retrospectively included patients who started alemtuzumab from January 2015 to December 2018, and recorded demographics, previous therapies, washout duration, relapses, Expanded Disability Status Scale (EDSS) score, and magnetic resonance imaging data. Negative binomial regression models were used to assess the effect of factors on annualized relapse (ARR) after alemtuzumab initiation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We studied 322 patients (mean age 36.8\u00a0years, median EDSS score 3, median follow\u2010up 1.94\u00a0years). Previous treatments were: fingolimod (106), natalizumab (80), first\u2010line oral agents (56), first\u2010line injectables (interferon\/glatiramer acetate; 30), and other drugs (15). Thirty\u2010five patients were treatment\u2010na\u00efve. The pre\u2010alemtuzumab ARR was 0.99 and decreased to 0.13 during alemtuzumab treatment (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.001). The number of previous\u2010year relapses was associated with alemtuzumab ARR (adjusted risk ratio [RR] 1.38, <jats:italic>p<\/jats:italic>\u00a0=\u00a00.009). Progression\u2010free survival was 94.5% after 1 year, and 89.2% after 2\u00a0years of alemtuzumab treatment. EDSS score improvement occurred in 13.5% after 1 year, and 20.6% after 2\u00a0years. Re\u2010baselining patients after 6\u00a0months of alemtuzumab treatment, led to no evidence of disease activity status in 71.6% after 1\u00a0year and 58.9% after 2\u00a0years.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Alemtuzumab decreases ARR independent of previous therapy, including patients with disease activity during natalizumab treatment. Overall, 90% of patients showed no disease progression, and 20% an improvement after 2\u00a0years of alemtuzumab.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ene.15121","type":"journal-article","created":{"date-parts":[[2021,9,24]],"date-time":"2021-09-24T23:49:41Z","timestamp":1632527381000},"page":"257-266","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["A real\u2010world study of alemtuzumab in a cohort of Italian patients"],"prefix":"10.1111","volume":"29","author":[{"given":"Cinzia Valeria","family":"Russo","sequence":"first","affiliation":[{"name":"NSRO Department University of Naples Federico II Napoli Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1323-6317","authenticated-orcid":false,"given":"Francesco","family":"Sacc\u00e0","sequence":"additional","affiliation":[{"name":"NSRO Department University of Naples Federico II Napoli Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9068-9144","authenticated-orcid":false,"given":"Jessica","family":"Frau","sequence":"additional","affiliation":[{"name":"Centro Sclerosi Multipla ASSL Cagliari (ATS Sardegna); Dipartimento di Scienze Mediche e Sanit\u00e0 Pubblica University of Cagliari Cagliari Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pietro","family":"Annovazzi","sequence":"additional","affiliation":[{"name":"Multiple Sclerosis Center ASST della Valle Olona Hospital of Gallarate Gallarate Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5753-6752","authenticated-orcid":false,"given":"Elisabetta","family":"Signoriello","sequence":"additional","affiliation":[{"name":"University of Campania Luigi Vanvitelli Napoli Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8561-9720","authenticated-orcid":false,"given":"Simona","family":"Bonavita","sequence":"additional","affiliation":[{"name":"University of Campania Luigi Vanvitelli Napoli Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberta","family":"Grasso","sequence":"additional","affiliation":[{"name":"University of Foggia Foggia Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marinella","family":"Clerico","sequence":"additional","affiliation":[{"name":"Dipartimento di Scienze Cliniche e Biologiche University of Torino Torino Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cinzia","family":"Cordioli","sequence":"additional","affiliation":[{"name":"Multiple Sclerosis Center ASST Spedali Civili di Brescia Montichiari Hospital Montichiari Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alice","family":"Laroni","sequence":"additional","affiliation":[{"name":"Department of Neurosciences, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health and Center of Excellence for Biomedical Research (CEBR) and IRCCS San Martino\u2010IST University of Genova Genova Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2501-2932","authenticated-orcid":false,"given":"Marco","family":"Capobianco","sequence":"additional","affiliation":[{"name":"SC Neurologia e Centro di Riferimento Regionale SM \u2010 AOU S. Luigi Orbassano, Torino Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valentina","family":"Torri Clerici","sequence":"additional","affiliation":[{"name":"Neuro\u2010Immunology and Neuromuscolar Diseases Unit IRCCS Foundation Carlo Besta Neurological Institute Milano Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arianna","family":"Sartori","sequence":"additional","affiliation":[{"name":"Clinical Unit of Neurology Department of Medicine Surgery and Health Sciences ASUGI University of Trieste Trieste Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paola","family":"Cavalla","sequence":"additional","affiliation":[{"name":"MS Center City of Health &amp; Science University Hospital Torino Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giorgia Teresa","family":"Maniscalco","sequence":"additional","affiliation":[{"name":"Multiple Sclerosis Center \"A. Cardarelli\" Hospital Naples Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara","family":"La Gioia","sequence":"additional","affiliation":[{"name":"Centro Sclerosi Multipla ASST Papa Giovanni XXIII Bergamo Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesca","family":"Caleri","sequence":"additional","affiliation":[{"name":"Neurology Department F. Tappeiner Hospital Meran (BZ) of Neurology Franz Tappeiner Hospital Merano Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessia","family":"Giugno","sequence":"additional","affiliation":[{"name":"Institute of Neurology Department of Medical and Surgical Sciences Magna Graecia University Catanzaro Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rosa","family":"Iodice","sequence":"additional","affiliation":[{"name":"NSRO Department University of Naples Federico II Napoli Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1574-9693","authenticated-orcid":false,"given":"Antonio","family":"Carotenuto","sequence":"additional","affiliation":[{"name":"NSRO Department University of Naples Federico II Napoli Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eleonora","family":"Cocco","sequence":"additional","affiliation":[{"name":"Centro Sclerosi Multipla ASSL Cagliari (ATS Sardegna); 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