{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,25]],"date-time":"2025-09-25T22:55:52Z","timestamp":1758840952931,"version":"3.40.5"},"reference-count":28,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2021,10,11]],"date-time":"2021-10-11T00:00:00Z","timestamp":1633910400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["SFB 1118","SFB 1158"],"award-info":[{"award-number":["SFB 1118","SFB 1158"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001661","name":"Universit\u00e4t Heidelberg","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001661","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Euro J of Neurology"],"published-print":{"date-parts":[[2022,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>We characterized and quantified peripheral nerve damage in alcohol\u2010dependent patients (ADP) by magnetic resonance neurography (MRN) in correlation with clinical and electrophysiologic findings.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Thirty\u2010one adult patients with a history of excessive alcohol consumption and age\u2010\/sex\u2010matched healthy controls were prospectively examined. After detailed neurologic and electrophysiologic testing, the patient group was subdivided into ADP with alcohol\u2010related polyneuropathy (ALN) and without ALN (Non\u2010ALN). 3T MRN with anatomical coverage from the proximal thigh down to the tibiotalar joint was performed using dual\u2010echo 2\u2010dimensional relaxometry sequences with spectral fat saturation. Detailed quantification of nerve injury by morphometric (cross\u2010sectional area [CSA]) and microstructural MRN markers (proton spin density [\u03c1], apparent T2\u2010relaxation\u2010time [T2<jats:sub>app<\/jats:sub>]) was conducted in all study participants.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>MRN detected nerve damage in ADP with and without ALN. A proximal\u2010to\u2010distal gradient was identified for nerve T2\u2010weighted (T2w)\u2010signal and T2<jats:sub>app<\/jats:sub> in ADP, indicating a proximal predominance of nerve lesions. While all MRN markers differentiated significantly between ADP and controls, microstructural markers were able to additionally differentiate between subgroups: tibial nerve \u03c1 at thigh level was increased in ALN (<jats:italic>p\u00a0<\/jats:italic>&lt;\u00a00.0001) and in Non\u2010ALN (<jats:italic>p\u00a0<\/jats:italic>=\u00a00.0052) versus controls, and T2<jats:sub>app<\/jats:sub> was higher in ALN versus controls (<jats:italic>p\u00a0<\/jats:italic>&lt;\u00a00.0001) and also in ALN versus Non\u2010ALN (<jats:italic>p\u00a0<\/jats:italic>=\u00a00.0214). T2w\u2010signal and CSA were only higher in ALN versus controls.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>MRN detects and quantifies peripheral nerve damage in ADP in vivo even in the absence of clinically overt ALN. Microstructural markers (T2<jats:sub>app<\/jats:sub>, \u03c1) are most suitable for differentiating between ADP with and without manifest ALN, and may help to elucidate the underlying pathomechanism in ALN.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ene.15127","type":"journal-article","created":{"date-parts":[[2021,9,26]],"date-time":"2021-09-26T13:29:20Z","timestamp":1632662960000},"page":"573-582","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Characterization and quantification of alcohol\u2010related polyneuropathy by magnetic resonance neurography"],"prefix":"10.1111","volume":"29","author":[{"given":"Christian","family":"Rother","sequence":"first","affiliation":[{"name":"Department of Neuroradiology Heidelberg University Hospital Heidelberg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jan Malte","family":"Bumb","sequence":"additional","affiliation":[{"name":"Department of Addictive Behavior and Addiction Medicine Central Institute of Mental Health Medical Faculty Mannheim\/Heidelberg University Mannheim Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8942-7662","authenticated-orcid":false,"given":"Markus","family":"Weiler","sequence":"additional","affiliation":[{"name":"Department of Neurology Heidelberg University Hospital Heidelberg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anna","family":"Brault","sequence":"additional","affiliation":[{"name":"Department of Neurology Heidelberg University Hospital Heidelberg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Georges","family":"Sam","sequence":"additional","affiliation":[{"name":"Department of Neurology Heidelberg University Hospital Heidelberg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John M.","family":"Hayes","sequence":"additional","affiliation":[{"name":"Department of Neurology University of Michigan Ann Arbor Michigan USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adriana","family":"Pietsch","sequence":"additional","affiliation":[{"name":"Department of Neuroradiology Heidelberg University Hospital Heidelberg Germany"},{"name":"Department of Internal Medicine Spital Walenstadt Walenstadt Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kianush","family":"Karimian\u2010Jazi","sequence":"additional","affiliation":[{"name":"Department of Neuroradiology Heidelberg University Hospital Heidelberg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1387-9304","authenticated-orcid":false,"given":"Johann M. 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