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Participants listened to words spoken with different prosodic stress that changed their meaning, and to words spoken with six different emotions, and chose which meaning or emotion was expressed. In the music tasks, participants judged pairs of short melodies as the same or different in terms of pitch or rhythm. Structural magnetic resonance imaging data were acquired at both stages, and machine learning\u2010based lesion\u2013symptom mapping and deterministic tractography were used to identify lesion patterns and damaged white matter pathways giving rise to aprosodia and amusia.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Both aprosodia and amusia were behaviorally strongly correlated and associated with similar lesion patterns in right frontoinsular and striatal areas. In multiple regression models, reduced fractional anisotropy and lower tract volume of the right inferior fronto\u2010occipital fasciculus were the strongest predictors for both disorders, over time.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>These results highlight a common origin of aprosodia and amusia, both arising from damage and disconnection of the right ventral auditory stream integrating rhythmic\u2013melodic acoustic information in prosody and music. Comorbidity of these disabilities may worsen the prognosis and affect rehabilitation success.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ene.15148","type":"journal-article","created":{"date-parts":[[2021,10,20]],"date-time":"2021-10-20T18:22:21Z","timestamp":1634754141000},"page":"873-882","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Right ventral stream damage underlies both poststroke aprosodia and amusia"],"prefix":"10.1111","volume":"29","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4501-7338","authenticated-orcid":false,"given":"Aleksi J.","family":"Sihvonen","sequence":"first","affiliation":[{"name":"Cognitive Brain Research Unit Department of Psychology and Logopedics Faculty of Medicine University of Helsinki Helsinki Finland"},{"name":"Centre for Clinical Research University of Queensland Brisbane Queensland Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniela","family":"Sammler","sequence":"additional","affiliation":[{"name":"Research Group \"Neurocognition of Music and Language Max Planck Institute for Empirical Aesthetics Frankfurt am Main Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pablo","family":"Ripoll\u00e9s","sequence":"additional","affiliation":[{"name":"Department of Psychology New York University New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vera","family":"Leo","sequence":"additional","affiliation":[{"name":"Cognitive Brain Research Unit Department of Psychology and Logopedics Faculty of Medicine University of Helsinki Helsinki Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antoni","family":"Rodr\u00edguez\u2010Fornells","sequence":"additional","affiliation":[{"name":"Cognition and Brain Plasticity Group Bellvitge Biomedical Research Institute, L'Hospitalet de Llobregat Spain"},{"name":"Department of Cognition Development, and Education Psychology University of Barcelona Barcelona Spain"},{"name":"Catalan Institution for Research and Advanced Studies Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seppo","family":"Soinila","sequence":"additional","affiliation":[{"name":"Neurocenter Turku University Hospital and Division of Clinical Neurosciences University of Turku Turku Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Teppo","family":"S\u00e4rk\u00e4m\u00f6","sequence":"additional","affiliation":[{"name":"Cognitive Brain Research Unit Department of Psychology and Logopedics Faculty of Medicine University of Helsinki Helsinki Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,10,27]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/aws354"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0447.1947.tb08246.x"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bandl.2007.04.007"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1080\/026870399401957"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1080\/02687030344000120"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1080\/13803395.2012.667069"},{"key":"e_1_2_9_8_1","unstructured":"HeilmanKM.Matter of mind: a neurologist's view of brain\u2010behavior relationships. 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