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Hierarchical regressions, linear mixed\u2010effects models, and Cox proportional hazards models were used to examine the interaction effects of \u03c9\u20103 supplementation with\n                      <jats:italic>APOE<\/jats:italic>\n                      \u03b54 and polygenic hazard scores, after adjusting for age, gender, education, cognitive diagnosis, insomnia, depression, anxiety, and cardiovascular risk score.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Individuals who progress to AD during the follow\u2010up tend to take a shorter duration of \u03c9\u20103 at baseline than those stable, for whom the difference remained significant only amongst\n                      <jats:italic>APOE<\/jats:italic>\n                      \u03b54 carriers (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a00.01). The interaction term (\n                      <jats:italic>APOE<\/jats:italic>\n                      \u03b54\u00a0\u00d7\u00a0\u03c9\u20103) accounted for a significant amount of variance in cognition and cerebral amyloid burden. Long\u2010term \u03c9\u20103 use protected cognition (especially memory function) and lowered amyloid burden and AD risk only amongst\n                      <jats:italic>APOE<\/jats:italic>\n                      \u03b54 carriers. Mediation analysis suggested that amyloid pathologies, brain reserve capacities, and brain metabolism mediated the relationships of \u03c9\u20103 use with memory and global cognition for\n                      <jats:italic>APOE<\/jats:italic>\n                      \u03b54 (+) carriers. Similar interaction and mediation effects were also indicated amongst high\u2010risk subjects defined by polygenic hazard scores.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Long\u2010term \u03c9\u20103 intake may have a role in AD prevention in genetically at\u2010risk populations.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/ene.15160","type":"journal-article","created":{"date-parts":[[2021,10,28]],"date-time":"2021-10-28T12:55:46Z","timestamp":1635425746000},"page":"422-431","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["A gene\u2013environment interplay between omega\u20103 supplementation and\n                    <i>APOE<\/i>\n                    \u03b54 provides insights for Alzheimer\u2019s disease precise prevention amongst high\u2010genetic\u2010risk population"],"prefix":"10.1111","volume":"29","author":[{"given":"Lin","family":"Li","sequence":"first","affiliation":[{"name":"Department of Neurology Qingdao Municipal Hospital Qingdao University Qingdao China"},{"name":"Department of Neurology Linyi People's Hospital Qingdao University Qingdao China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3310-5875","authenticated-orcid":false,"given":"Wei","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Neurology Qingdao Municipal Hospital Qingdao University Qingdao China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chen\u2010Chen","family":"Tan","sequence":"additional","affiliation":[{"name":"Department of Neurology Qingdao Municipal Hospital Qingdao University Qingdao China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xi\u2010Peng","family":"Cao","sequence":"additional","affiliation":[{"name":"Department of Neurology Qingdao 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