{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T06:01:16Z","timestamp":1790834476699,"version":"4.1.0"},"reference-count":50,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2021,11,21]],"date-time":"2021-11-21T00:00:00Z","timestamp":1637452800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100014838","name":"Deutsche Parkinson Vereinigung","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100014838","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Euro J of Neurology"],"published-print":{"date-parts":[[2022,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and purpose<\/jats:title><jats:p>Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disorder with predominant progressive degeneration of motor neurons and motor deficits, but non\u2010motor symptoms (NMS) such as cognitive and behavioural deficits are frequent and underestimated in current diagnostic pathways. Autonomic dysfunction has occasionally been described, although its frequency and relevance are unclear. The aim of this study was to investigate the role of the autonomic nervous system in ALS using a multimodal approach.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Thirty\u2010seven ALS patients and 40\u00a0healthy sex\u2010 and age\u2010matched controls were included. NMS were studied with the NMS assessment scale for Parkinson's disease and an autonomic subscale was calculated. Cardioautonomic innervation at rest and whilst standing was assessed by different parameters of heart rate variability. Morphological changes (cross\u2010sectional area) of the vagus and median nerves for control were measured with high\u2010resolution ultrasound.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Non\u2010motor symptoms in general were more frequent in ALS patients and correlated inversely with the ALS Functional Rating Scale whereas the autonomic subscore of the NMS assessment scale for Parkinson's disease did not differ between the two groups and was not related to functional impairment. Cardioautonomic assessment solely revealed an increased heart rate at rest in ALS patients, whereas the other heart rate variability parameters did not differ from controls. Structural sonographic investigation of the vagus and median nerves was similar in both groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Using a multimodal approach evidence was found for a rather mild cardio\u2010sympathetic overactivity in ALS patients. Overall, autonomic dysfunction seems to be subtle and is not related to the functional state of ALS patients.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ene.15177","type":"journal-article","created":{"date-parts":[[2021,11,8]],"date-time":"2021-11-08T15:36:45Z","timestamp":1636385805000},"page":"715-723","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":36,"title":["Multimodal assessment of autonomic dysfunction in amyotrophic lateral sclerosis"],"prefix":"10.1111","volume":"29","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5772-6609","authenticated-orcid":false,"given":"David","family":"Weise","sequence":"first","affiliation":[{"name":"Department of Neurology Leipzig University Hospital Leipzig Germany"},{"name":"Department of Neurology Asklepios Fachklinikum Stadtroda Stadtroda Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ina","family":"Menze","sequence":"additional","affiliation":[{"name":"Department of Neurology Leipzig University Hospital Leipzig Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Moritz C. 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