{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T04:01:56Z","timestamp":1793073716929,"version":"4.5.0"},"reference-count":36,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2021,11,19]],"date-time":"2021-11-19T00:00:00Z","timestamp":1637280000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Euro J of Neurology"],"published-print":{"date-parts":[[2022,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and purpose<\/jats:title><jats:p>Optic neuritis (ON) is often the initial symptom of neuromyelitis optica spectrum disorder (NMOSD) and myelin oligodendrocyte glycoprotein\u2010associated disease (MOGAD). We aimed to compare the frequency and pattern of chiasmatic lesions in MOGAD\u2010related ON (MOGAD\u2010ON) and NMOSD\u2010related ON (NMOSD\u2010ON) using conventional brain imaging (magnetic resonance imaging [MRI]) in Latin America (LATAM).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We reviewed the medical records and brain MRI (\u226430\u00a0days from ON onset) of patients with a first event of MOGAD\u2010ON and NMOSD\u2010ON. Patients from Argentina (<jats:italic>n<\/jats:italic>\u00a0=\u00a072), Chile (<jats:italic>n<\/jats:italic>\u00a0=\u00a021), Ecuador (<jats:italic>n<\/jats:italic>\u00a0=\u00a031), Brazil (<jats:italic>n<\/jats:italic>\u00a0=\u00a030), Venezuela (<jats:italic>n<\/jats:italic>\u00a0=\u00a010) and Mexico (<jats:italic>n<\/jats:italic>\u00a0=\u00a082) were included. Antibody status was tested using a cell\u2010based assay. Demographic, clinical, imaging and prognostic (as measured by the Visual Functional System Score [VFSS] of the Expanded Disability Status Scale) data were compared.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 246 patients (208\u00a0NMOSD and 38\u00a0MOGAD) were included. No differences were found in gender and ethnicity between the groups. We observed chiasmatic lesions in 66\/208 (31.7%) NMOSD\u2010ON and in 5\/38 (13.1%) MOGAD\u2010ON patients (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.01). Of these patients with chiasmatic lesions, 54\/66 (81.8%) and 4\/5\u00a0had associated longitudinally extensive optic nerve lesions, 45\/66 (68%) and 4\/5\u00a0had bilateral lesions, and 31\/66 (47%) and 4\/5\u00a0showed gadolinium\u2010enhancing chiasmatic lesions, respectively. A positive correlation was observed between VFSS and presence of bilateral (<jats:italic>r<\/jats:italic>\u00a0=\u00a00,28, <jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.0001), chiasmatic (<jats:italic>r<\/jats:italic>\u00a0=\u00a00.27, <jats:italic>p<\/jats:italic>\u00a0=\u00a00.0001) and longitudinally extensive lesions (<jats:italic>r<\/jats:italic>\u00a0=\u00a00,25, <jats:italic>p<\/jats:italic>\u00a0=\u00a00.0009) in the NMOSD\u2010ON group, but no correlations were observed in the MOGAD\u2010ON group.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Chiasmatic lesions were significantly more common in NMOSD than in MOGAD during an ON attack in this LATAM cohort. Further studies are needed to assess the generalizability of these results.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ene.15178","type":"journal-article","created":{"date-parts":[[2021,11,20]],"date-time":"2021-11-20T05:51:55Z","timestamp":1637387515000},"page":"802-809","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Chiasmatic lesions on conventional magnetic resonance imaging during the first event of optic neuritis in patients with neuromyelitis optica spectrum disorder and myelin oligodendrocyte glycoprotein\u2010associated disease in a Latin American cohort"],"prefix":"10.1111","volume":"29","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7435-5726","authenticated-orcid":false,"given":"Edgar","family":"Carnero Contentti","sequence":"first","affiliation":[{"name":"Neuroimmunology Unit, Department of Neuroscience Hospital Alem\u00e1n Buenos Aires 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