{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,13]],"date-time":"2026-01-13T13:39:56Z","timestamp":1768311596997,"version":"3.49.0"},"reference-count":27,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2021,12,23]],"date-time":"2021-12-23T00:00:00Z","timestamp":1640217600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Euro J of Neurology"],"published-print":{"date-parts":[[2022,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and purpose<\/jats:title><jats:p>Stroke\u2010related restless legs syndrome (sRLS) secondary to ischemic lesions is an emerging entity and an interesting condition, but there are limited available data to help us further understand its underlying pathways. In this study, we characterized sRLS clinically, neuroanatomically and functionally.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Consecutive patients hospitalized in the Stroke Unit of the University Hospital of Strasbourg were assessed clinically and electrophysiologically for sRLS characteristics. They underwent brain magnetic resonance imaging for the neuroanatomical study of involved structures, and received functional evaluations with <jats:sup>18<\/jats:sup>F\u2010FDG (2\u2010deoxy\u20102\u2010[fluorine\u201018]fluoro\u2010D\u2010glucose) positron emission tomography (PET) for glucose consumption, <jats:sup>123<\/jats:sup>I\u2010FP\u2010CIT ([123]I\u20102beta\u2010carbometoxy\u20103beta\u2010[4\u2010iodophenyl]\u2010N\u2010[3\u2010fluoropropyl]nortropane) single\u2010photon emission computed tomography for dopamine reuptake and PET with <jats:sup>18<\/jats:sup>F\u2010FDOPA ((3,4\u2010dihydroxy\u20106\u2010[18]F\u2010fluoro\u2010l\u2010phenylalanine) for presynaptic dopaminergic synthesis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Sixteen patients with sRLS, eight women and eight\u00a0men, aged 41\u201381\u00a0years, were included. The clinical characteristics of sRLS and idiopathic RLS were similar. Most patients presented with bilateral and symmetric <jats:italic>de novo<\/jats:italic> RLS. Eight patients had infarction in the lenticulostriate area (middle cerebral artery and internal carotid arteria). The body of the caudate nucleus was most commonly affected. Seven patients had sRLS secondary to ventral brainstem infarction (perforating branches of the basilar arteria) affecting the pons in six patients and the medulla oblongata in one patient. Both the corticospinal tract and the cortico\u2010pontocerebellar fibres were lesioned in all patients with brainstem stroke. One patient had infarction in the left posterior cerebellar vermis and occipital area (posterior cerebral artery and superior cerebellar artery). Isotopic explorations showed a significantly increased dopaminergic tone in the striatum ipsilateral to lenticulostriate infarction. Dopamine fixation was normal in patients with stroke outside of the lenticulostriate area.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Clinicians should be aware of the characteristics of sRLS for the appropriate diagnosis and treatment of this condition.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ene.15207","type":"journal-article","created":{"date-parts":[[2021,12,10]],"date-time":"2021-12-10T07:25:27Z","timestamp":1639121127000},"page":"1011-1016","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Stroke\u2010related restless legs syndrome: Clinical and anatomo\u2010functional characterization of an emerging entity"],"prefix":"10.1111","volume":"29","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0361-0985","authenticated-orcid":false,"given":"Elisabeth","family":"Ruppert","sequence":"first","affiliation":[{"name":"Department of Neurology, Sleep and Electrophysiology Clinic \u2010 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Jacques","family":"Namer","sequence":"additional","affiliation":[{"name":"Faculty of Medicine University of Strasbourg Strasbourg France"},{"name":"Department of Biophysics and Nuclear Medicine University Hospital of Strasbourg Strasbourg France"},{"name":"ICube University of Strasbourg\/CNRS, UMR 7357 Strasbourg France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Val\u00e9rie","family":"Wolff","sequence":"additional","affiliation":[{"name":"Faculty of Medicine University of Strasbourg Strasbourg France"},{"name":"Stroke Unit University Hospital of Strasbourg Strasbourg France"},{"name":"EA3072, Federation of Translational Medicine of Strasbourg University of Strasbourg Strasbourg France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"St\u00e9phane","family":"Kremer","sequence":"additional","affiliation":[{"name":"ICube University of Strasbourg\/CNRS, UMR 7357 Strasbourg France"},{"name":"Department of Imaging 2 University Hospital of Strasbourg 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