{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T20:27:34Z","timestamp":1791491254367,"version":"4.3.4"},"reference-count":18,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2022,2,9]],"date-time":"2022-02-09T00:00:00Z","timestamp":1644364800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Euro J of Neurology"],"published-print":{"date-parts":[[2022,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and purpose<\/jats:title><jats:p>Orthostatic tremor and spinal cord melanoma are rare entities and seem unlikely to be associated. Herein, we report a patient diagnosed with orthostatic tremor secondary to primary malignant melanoma of the spinal cord.<\/jats:p><\/jats:sec><jats:sec><jats:title>Case Presentation<\/jats:title><jats:p>We report the case of a 67\u2010year\u2010old man who experienced tremor when he was standing, which disappeared when he was sitting or walking. He also reported gait disturbance and cognitive dysfunction. Electromyography revealed a regular and symmetric high\u2010frequency tremor in the lower extremities. The patient was admitted to a hospital several times and was diagnosed with primary orthostatic tremor and later hydrocephalus; thus, he received a ventriculoperitoneal shunt. Finally, he showed symptoms of the presence of melanoma in the spinal cord, which was supported by spinal cord magnetic resonance imaging findings. Primary malignant melanoma of the spinal cord was confirmed postoperatively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Orthostatic tremor is a rare entity that can be characterized by specific high\u2010frequency tremors when the subject is standing. Considering that it remains unknown why this condition appears, some possible associations, such as primary spinal cord melanoma, should be considered. Thus, a comprehensive assessment of these types of patients is required. Our case report may facilitate the understanding of the pathophysiology and clinical symptoms of this disease.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ene.15208","type":"journal-article","created":{"date-parts":[[2022,2,10]],"date-time":"2022-02-10T06:12:12Z","timestamp":1644473532000},"page":"942-946","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Orthostatic tremor secondary to primary malignant melanoma of the spinal cord: A case report"],"prefix":"10.1111","volume":"29","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2038-3101","authenticated-orcid":false,"given":"Hongbo","family":"Lv","sequence":"first","affiliation":[{"name":"Department of Neurology Qilu Hospital, Cheeloo College of Medicine Shandong University Jinan Shandong Province China"},{"name":"Shandong University Jinan Shandong Province China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chengyuan","family":"Song","sequence":"additional","affiliation":[{"name":"Department of Neurology Qilu Hospital, Cheeloo College of Medicine Shandong University Jinan Shandong Province China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Neurology Qilu Hospital, Cheeloo College of Medicine Shandong University Jinan Shandong Province China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7200-7197","authenticated-orcid":false,"given":"Yiming","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Neurology Qilu Hospital, Cheeloo College of Medicine Shandong University Jinan Shandong Province China"},{"name":"Shandong University Jinan Shandong Province China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,2,9]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.1984.04050190086020"},{"key":"e_1_2_8_3_1","first-page":"450","article-title":"On an unusual disorder of erect standing position (observation of 3 cases)","volume":"94","author":"Pazzaglia P","year":"1970","journal-title":"Riv Sper Freniatr Med Leg Alien Ment"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11940-018-0524-3"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-444-52014-2.00035-5"},{"issue":"3","key":"e_1_2_8_6_1","first-page":"2","article-title":"Consensus statement of the Movement Disorder Society on Tremor. 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