{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T14:01:05Z","timestamp":1788184865403,"version":"build-2803163510"},"reference-count":28,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2022,1,21]],"date-time":"2022-01-21T00:00:00Z","timestamp":1642723200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Euro J of Neurology"],"published-print":{"date-parts":[[2022,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and purpose<\/jats:title><jats:p>Erenumab (ERE) is the first anticalcitonin gene\u2010related peptide receptor monoclonal antibody approved for migraine prevention. A proportion of patients do not adequately respond to ERE.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Prospective multicenter study involving 110 migraine patients starting ERE 70\u00a0mg monthly. Baseline socio\u2010demographics and migraine characteristics, including mean monthly migraine days (MMDs), migraine\u2010related burden (MIDAS [Migraine Disability Assessment scale] and Headache Impact Test\u20106), and use of abortive medications, during 3\u00a0months before and after ERE start were collected. Real\u2010time polymerase chain reaction was used to determine polymorphic variants of calcitonin receptor\u2010like receptor and receptor activity\u2010modifying protein\u20101 genes. Logistic regression models were used to identify independent predictors for 50% responder patients (50\u2010RESP) and 75% responder patients (75\u2010RESP).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>At month 3, MMDs decreased from 17.2 to 9.2 (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.0001), 59\/110 (53.6%) patients were 50\u2010RESP, and 30\/110 (27.3%) were 75\u2010RESP. Age at migraine onset (odds ratio [OR] [95% confidence interval (95% CI)]: 1.062 [1.008\u20131.120], <jats:italic>p<\/jats:italic>\u00a0=\u00a00.024), number of failed preventive medications (0.753 [0.600\u20130.946], <jats:italic>p<\/jats:italic>\u00a0=\u00a00.015), and MIDAS score (1.011 [1.002\u20131.020], <jats:italic>p<\/jats:italic>\u00a0=\u00a00.017) were associated with 75\u2010RESP. Among the genetic variants investigated, <jats:italic>RAMP1<\/jats:italic> <jats:italic>rs7590387<\/jats:italic> was found associated with a lower probability of being 75\u2010RESP (per G allele OR [95% CI]: 0.53 [0.29\u20130.99], <jats:italic>p<\/jats:italic>\u00a0=\u00a00.048]), but this association did not survive adjustment for confounding clinical variables (per G allele, 0.55 [0.28\u20131.10], <jats:italic>p<\/jats:italic>\u00a0=\u00a00.09]).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>In this real\u2010word study, treatment with ERE significantly reduced MMDs. The number of failed preventive medications, migraine burden, and age at migraine onset predicted response to ERE. Larger studies are required to confirm a possible role of <jats:italic>RAMP1 rs7590387<\/jats:italic> as genetic predictor of ERE efficacy.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ene.15236","type":"journal-article","created":{"date-parts":[[2021,12,29]],"date-time":"2021-12-29T16:40:57Z","timestamp":1640796057000},"page":"1209-1217","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":41,"title":["Clinic and genetic predictors in response to erenumab"],"prefix":"10.1111","volume":"29","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9990-3431","authenticated-orcid":false,"given":"Chiara","family":"Zecca","sequence":"first","affiliation":[{"name":"Department of Neurology Neurocenter of Southern Switzerland Ospedale Regionale di Lugano EOC Lugano Switzerland"},{"name":"Faculty of Biomedical Sciences Universit\u00e0 della Svizzera Italiana Lugano Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah","family":"Cargnin","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Sciences and Interdepartmental Research Center of Pharmacogenetics and Pharmacogenomics (CRIFF) University of Piemonte Orientale \"A. Avogadro\" Novara Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christoph","family":"Schankin","sequence":"additional","affiliation":[{"name":"Department of Neurology Inselspital Bern University Hospital University of Bern Bern Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nadia Mariagrazia","family":"Giannantoni","sequence":"additional","affiliation":[{"name":"Department of Neurology Neurocenter of Southern Switzerland Ospedale Regionale di Lugano EOC Lugano Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4356-8109","authenticated-orcid":false,"given":"Michele","family":"Viana","sequence":"additional","affiliation":[{"name":"Department of Neurology Neurocenter of Southern Switzerland Ospedale Regionale di Lugano EOC Lugano Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabella","family":"Maraffi","sequence":"additional","affiliation":[{"name":"Department of Neurology Neurocenter of Southern Switzerland Ospedale Regionale di Lugano EOC Lugano Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1202-5534","authenticated-orcid":false,"given":"Gianna Carla","family":"Riccitelli","sequence":"additional","affiliation":[{"name":"Department of Neurology Neurocenter of Southern Switzerland Ospedale Regionale di Lugano EOC Lugano Switzerland"},{"name":"Faculty of Biomedical Sciences Universit\u00e0 della Svizzera Italiana Lugano Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shairin","family":"Sihabdeen","sequence":"additional","affiliation":[{"name":"Department of Neurology Neurocenter of Southern Switzerland Ospedale Regionale di Lugano EOC Lugano Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Salvatore","family":"Terrazzino","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Sciences and Interdepartmental Research Center of Pharmacogenetics and Pharmacogenomics (CRIFF) University of Piemonte Orientale \"A. 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