{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,6,21]],"date-time":"2025-06-21T19:24:20Z","timestamp":1750533860896,"version":"3.40.5"},"reference-count":48,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2022,1,26]],"date-time":"2022-01-26T00:00:00Z","timestamp":1643155200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100003710","name":"Korea Health Industry Development Institute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003710","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Euro J of Neurology"],"published-print":{"date-parts":[[2022,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and purpose<\/jats:title><jats:p>Previous studies have developed several cognitive composites in preclinical Alzheimer disease (AD). However, more sensitive measures to track cognitive changes and therapeutic efficacy in preclinical AD are needed considering the diverse sociocultural and linguistic backgrounds. This study developed a composite score that can sensitively detect the amyloid\u2010\u03b2 (A\u03b2)\u2010related cognitive trajectory of preclinical AD using Korean data.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A total of 196 cognitively normal participants who underwent amyloid positron emission tomography were followed\u2010up with neuropsychological assessments. We developed the Longitudinal Amyloid Cognitive Composite in Preclinical AD (LACPA) using the linear mixed\u2010effects model (LMM) and <jats:italic>z<\/jats:italic> scores. The LMM was also used to investigate the longitudinal sensitivity of the LACPA and the association between time\u2010varying brain atrophy and the LACPA.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Considering the group\u2010time interaction effects of each subtest, the Seoul Verbal Learning Test\u2010Elderly version immediate recall\/delayed recall\/recognition, the Korean Trail Making Test B Time, and the Korean Mini\u2010Mental State Examination were selected as components of the LACPA. The LACPA exhibited a significant group\u2010time interaction effect between the A\u03b2+ and A\u03b2\u2212 groups (<jats:italic>t<\/jats:italic>\u00a0=\u00a0\u22123.288, <jats:italic>p<\/jats:italic>\u00a0=\u00a00.001). Associations between time\u2010varying LACPA and brain atrophy were found in the bilateral medial temporal, right lateral parietal, and right lateral frontal regions, and hippocampal volume.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The LACPA may contribute to reduction in time and financial burden when monitoring A\u03b2\u2010related cognitive decline and therapeutic efficacy of the disease\u2010modifying agents specifically targeting A\u03b2 in secondary prevention trials.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ene.15241","type":"journal-article","created":{"date-parts":[[2021,12,31]],"date-time":"2021-12-31T15:00:12Z","timestamp":1640962812000},"page":"980-989","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Longitudinal amyloid cognitive composite in preclinical Alzheimer\u2019s disease"],"prefix":"10.1111","volume":"29","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2927-6724","authenticated-orcid":false,"given":"Young Ju","family":"Kim","sequence":"first","affiliation":[{"name":"Department of Neurology Samsung Medical Center Sungkyunkwan University School of Medicine  Seoul Korea"},{"name":"Neuroscience Center Samsung Medical Center  Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alice","family":"Hahn","sequence":"additional","affiliation":[{"name":"Department of Neurology Samsung Medical Center Sungkyunkwan University School of Medicine  Seoul Korea"},{"name":"Neuroscience Center Samsung Medical Center  Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yu Hyun","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Neurology Samsung Medical Center Sungkyunkwan University School of Medicine  Seoul Korea"},{"name":"Neuroscience Center Samsung Medical Center  Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Duk L.","family":"Na","sequence":"additional","affiliation":[{"name":"Department of Neurology Samsung Medical Center Sungkyunkwan University School of Medicine  Seoul Korea"},{"name":"Neuroscience Center Samsung Medical Center  Seoul Korea"},{"name":"Stem Cell &amp; Regenerative Medicine Institute  Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juhee","family":"Chin","sequence":"additional","affiliation":[{"name":"Department of Neurology Samsung Medical Center Sungkyunkwan University School of Medicine  Seoul Korea"},{"name":"Neuroscience Center Samsung Medical Center  Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sang Won","family":"Seo","sequence":"additional","affiliation":[{"name":"Department of Neurology Samsung Medical Center Sungkyunkwan University School of Medicine  Seoul Korea"},{"name":"Neuroscience Center Samsung Medical Center  Seoul Korea"},{"name":"Samsung Alzheimer Research Center  Seoul Korea"},{"name":"Center for Clinical Epidemiology Samsung Medical Center  Seoul Korea"},{"name":"Department of Health Sciences and Technology SAIHST Sungkyunkwan University  Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,1,26]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(12)70291-0"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1202753"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaneurol.2013.1062"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(18)30028-0"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(13)70044-9"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/9781444341256.ch12"},{"issue":"4","key":"e_1_2_11_8_1","first-page":"208","article-title":"The trial\u2010ready cohort for preclinical\/prodromal Alzheimer's disease (TRC\u2010PAD) project: an overview","volume":"7","author":"Aisen PS","year":"2020","journal-title":"J Prev Alzheimers Dis"},{"key":"e_1_2_11_9_1","unstructured":"U.S. Department of Health and Human Services Food and Drug Administration Center for Drug Evaluation and Research (CDER) Center for Biologics Evaluation and Research (CBER).Guidance for Industry: Alzheimer\u2019s Disease: Developing Drugs for the Treatment of Early Stage Disease.https:\/\/www.fda.gov\/media\/110903\/download. 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