{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,6]],"date-time":"2026-09-06T00:54:24Z","timestamp":1788656064951,"version":"build-2803163510"},"reference-count":28,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2022,2,19]],"date-time":"2022-02-19T00:00:00Z","timestamp":1645228800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100002347","name":"Bundesministerium f\u00fcr Bildung und Forschung","doi-asserted-by":"publisher","award":["01KX2130"],"award-info":[{"award-number":["01KX2130"]}],"id":[{"id":"10.13039\/501100002347","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Euro J of Neurology"],"published-print":{"date-parts":[[2022,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and purpose<\/jats:title><jats:p>Currently, the extent of cholinergic basal forebrain atrophy in relatively pure limbic TAR DNA\u2010binding protein 43 (TDP\u201043) pathology compared with relatively pure Alzheimer disease (AD) is unclear.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We compared antemortem magnetic resonance imaging (MRI)\u2010based atrophy of the basal forebrain and medial and lateral temporal lobe volumes between 10 autopsy cases with limbic TDP\u201043 pathology and 33 cases with AD pathology on postmortem neuropathologic examination from the Alzheimer's Disease Neuroimaging Initiative cohort. For reference, we studied MRI volumes from cognitively healthy, amyloid positron emission tomography\u2010negative subjects (<jats:italic>n<\/jats:italic>\u00a0=\u00a0145). Group differences were assessed using Bayesian analysis of covariance. In addition, we assessed brain\u2010wide regional volume changes using partial least squares regression (PLSR).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We found extreme evidence (Bayes factor [BF]<jats:sub>01<\/jats:sub>\u00a0&gt;\u00a0600) for a smaller basal forebrain volume in both TDP\u201043 and AD cases compared with amyloid\u2010negative controls, and moderate evidence (BF<jats:sub>01<\/jats:sub>\u00a0=\u00a04.9) that basal forebrain volume was not larger in TDP\u201043 than in AD cases. The ratio of hippocampus to lateral temporal lobe volumes discriminated between TDP\u201043 and AD cases with an accuracy of 0.78. PLSR showed higher gray matter in lateral temporal lobes and cingulate and precuneus, and reduced gray matter in precentral and postcentral gyri and hippocampus in TDP\u201043 compared with AD cases.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Atrophy of the cholinergic basal forebrain appears to be similarly pronounced in cases with limbic TDP\u201043 pathology as in AD. This suggests that a clinical trial of the efficacy of cholinesterase inhibitors in amyloid\u2010negative cases with amnestic dementia and an imaging signature of TDP\u201043 pathology may be warranted.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ene.15270","type":"journal-article","created":{"date-parts":[[2022,2,5]],"date-time":"2022-02-05T02:09:15Z","timestamp":1644026955000},"page":"1394-1401","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Antemortem basal forebrain atrophy in pure limbic TAR DNA\u2010binding protein 43 pathology compared with pure Alzheimer pathology"],"prefix":"10.1111","volume":"29","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3586-3194","authenticated-orcid":false,"given":"Stefan J.","family":"Teipel","sequence":"first","affiliation":[{"name":"Deutsches Zentrum f\u00fcr Neurodegenerative Erkrankungen (DZNE) Rostock\/Greifswald  Rostock Germany"},{"name":"Department of Psychosomatic Medicine University Medicine Rostock  Rostock Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michel J.","family":"Grothe","sequence":"additional","affiliation":[{"name":"Deutsches Zentrum f\u00fcr Neurodegenerative Erkrankungen (DZNE) Rostock\/Greifswald  Rostock Germany"},{"name":"Movement Disorders Unit Neurology and Clinical Neurophysiology Service Institute of Biomedicine of Seville (IBiS) Virgen del Roc\u00edo University Hospital\/Spanish National Research Council (CSIC)\/University of Seville  Seville Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"for the Alzheimer's Disease Neuroimaging 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