{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T21:19:52Z","timestamp":1789507192526,"version":"build-2803163510"},"reference-count":18,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2022,3,7]],"date-time":"2022-03-07T00:00:00Z","timestamp":1646611200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Euro J of Neurology"],"published-print":{"date-parts":[[2022,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and purpose<\/jats:title><jats:p>Despite the increasing number of reports on the spectrum of neurological manifestations of COVID\u201019 (neuro\u2010COVID), few studies have assessed short\u2010 and long\u2010term outcome of the disease.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This is a cohort study enrolling adult patients with neuro\u2010COVID seen in neurological consultation. Data were collected prospectively or retrospectively in the European Academy of Neurology NEuro\u2010covid ReGistrY ((ENERGY). The outcome at discharge was measured using the modified Rankin Scale and defined as \u2018stable\/improved\u2019 if the modified Rankin Scale score was equal to or lower than the pre\u2010morbid score, \u2018worse\u2019 if the score was higher than the pre\u2010morbid score. Status at 6\u00a0months was also recorded. Demographic and clinical variables were assessed as predictors of outcome at discharge and 6\u00a0months.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>From July 2020 to March 2021, 971 patients from 19 countries were included. 810 (83.4%) were hospitalized. 432 (53.3%) were discharged with worse functional status. Older age, stupor\/coma, stroke and intensive care unit (ICU) admission were predictors of worse outcome at discharge. 132 (16.3%) died in hospital. Older age, cancer, cardiovascular complications, refractory shock, stupor\/coma and ICU admission were associated with death. 262 were followed for 6\u00a0months. Acute stroke or ataxia, ICU admission and degree of functional impairment at discharge were predictors of worse outcome. 65\/221 hospitalized patients (29.4%) and 10\/32 non\u2010hospitalized patients (24.4%) experienced persisting neurological symptoms\/signs. 10\/262 patients (3.8%) developed new neurological complaints during the 6\u00a0months of follow\u2010up.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Neuro\u2010COVID is a severe disease associated with worse functional status at discharge, particularly in older subjects and those with comorbidities and acute complications of infection.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ene.15293","type":"journal-article","created":{"date-parts":[[2022,2,23]],"date-time":"2022-02-23T12:34:54Z","timestamp":1645619694000},"page":"1663-1684","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":36,"title":["Short\u2010 and long\u2010term outcome and predictors in an international cohort of patients with neuro\u2010COVID\u201019"],"prefix":"10.1111","volume":"29","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2542-0469","authenticated-orcid":false,"given":"Ettore","family":"Beghi","sequence":"first","affiliation":[{"name":"Istituto di Ricerche Farmacologiche Mario Negri IRCCS  Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5682-0145","authenticated-orcid":false,"given":"Raimund","family":"Helbok","sequence":"additional","affiliation":[{"name":"Neurological Intensive Care Unit Department of Neurology Medical University of Innsbruck  Innsbruck Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Serefnur","family":"Ozturk","sequence":"additional","affiliation":[{"name":"Selcuk University Faculty of Medicine Department of Neurology  Konya Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Omer","family":"Karadas","sequence":"additional","affiliation":[{"name":"Neurology Department Gulhane School of Medicine University of Health Science  Ankara Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vitalie","family":"Lisnic","sequence":"additional","affiliation":[{"name":"Neurology Nicolae Testemiceanu State Medical and Pharmaceutical University  Chi\u0219in\u0103u Moldova"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oxana","family":"Grosu","sequence":"additional","affiliation":[{"name":"Neurology Nicolae Testemiceanu State Medical and Pharmaceutical University  Chi\u0219in\u0103u Moldova"},{"name":"Neurology Academy of Sciences of Moldova  Chi\u0219in\u0103u 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