{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,11]],"date-time":"2026-07-11T17:33:21Z","timestamp":1783791201545,"version":"3.55.0"},"reference-count":12,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2022,3,14]],"date-time":"2022-03-14T00:00:00Z","timestamp":1647216000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Euro J of Neurology"],"published-print":{"date-parts":[[2022,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and purpose<\/jats:title><jats:p>Anti\u2010myelin oligodendrocyte glycoprotein antibodies (MOG\u2010Abs) distinguish a group of inflammatory disorders which can be preceded by specific or non\u2010specific infections. A few single cases have been reported in association with SARS\u2010CoV\u20102 infection, but a specific study on the correlation between COVID\u201019 and myelin oligodendrocyte glycoprotein (MOG)\u2010associated disorder (MOGAD) has not yet been performed. The aim of this study was to determine the impact of the pandemic on this condition.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We analysed SARS\u2010CoV\u20102\u00a0serology in patients newly diagnosed with MOGAD (1 August 2020 to 31 May 2021). MOG\u2010Ab\u2010seronegative age\u2010 and time\u2010matched subjects were used as controls. SARS\u2010CoV\u20102 immunoglobulin G (IgG) levels were analysed using an anti\u2010SARS\u2010CoV\u20102 US Food and Drug Administration\u2010approved ELISA assay and confirmed with a trimeric anti\u2010SARS\u2010CoV\u20102 S1\/S2 IgG immunochemiluminescent test, concomitantly assaying the anti\u2010receptor binding domain (RBD) of spike protein IgG and anti\u2010RBD total Ig. We actually compared the number of cases referred in each of the last 3 years.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Presence of SARS\u2010CoV\u20102 IgG antibodies was more common (12\/30, 40%) in MOGAD patients than in controls (6\/30, 20%), although the difference was not significant (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.16; odds ratio\u00a02.67, 95% confidence interval 0.85\u20139.17). The most common clinical presentations of MOGAD SARS\u2010CoV\u20102\u2010seropositive patients included optic neuritis (<jats:italic>n<\/jats:italic>\u00a0=\u00a06) and myelitis (<jats:italic>n<\/jats:italic>\u00a0=\u00a03). The number of diagnosed cases increased over the last 3\u00a0years, in particular, when including cases referred to us before the COVID\u201019 pandemic, in the initial phase of the first wave and in the late phase of the second wave (<jats:italic>n<\/jats:italic>\u00a0=\u00a09, rate 10.6% in 2019; <jats:italic>n<\/jats:italic>\u00a0=\u00a013, rate 12.3% in 2020; <jats:italic>n<\/jats:italic>\u00a0=\u00a015, rate 14.7% in 2021).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Our findings provide preliminary data on SARS\u2010CoV\u20102 as a potential trigger of MOGAD.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ene.15304","type":"journal-article","created":{"date-parts":[[2022,2,28]],"date-time":"2022-02-28T07:58:45Z","timestamp":1646035125000},"page":"1855-1858","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":24,"title":["Is there a correlation between MOG\u2010associated disorder and SARS\u2010CoV\u20102 infection?"],"prefix":"10.1111","volume":"29","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7806-3103","authenticated-orcid":false,"given":"Sara","family":"Mariotto","sequence":"first","affiliation":[{"name":"Neurology Unit Department of Neurosciences, Biomedicine, and Movement Sciences University of Verona  Verona Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara","family":"Carta","sequence":"additional","affiliation":[{"name":"Neurology Unit Department of Neurosciences, Biomedicine, and Movement Sciences University of Verona  Verona Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3249-4792","authenticated-orcid":false,"given":"Alessandro","family":"Dinoto","sequence":"additional","affiliation":[{"name":"Neurology Unit Department of Neurosciences, Biomedicine, and Movement Sciences University of Verona  Verona Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giuseppe","family":"Lippi","sequence":"additional","affiliation":[{"name":"Section of Clinical Biochemistry University of Verona  Verona Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gian Luca","family":"Salvagno","sequence":"additional","affiliation":[{"name":"Section of Clinical Biochemistry University of Verona  Verona Italy"},{"name":"Service of Laboratory Medicine Pederzoli Hospital  Verona Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Masin","sequence":"additional","affiliation":[{"name":"Neurology Unit Department of Neurosciences, Biomedicine, and Movement Sciences University of Verona  Verona Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniela","family":"Alberti","sequence":"additional","affiliation":[{"name":"Neurology Unit Department of Neurosciences, Biomedicine, and Movement Sciences University of Verona  Verona Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Romain","family":"Marignier","sequence":"additional","affiliation":[{"name":"Service de Neurologie Scl\u00e9rose en Plaques Pathologies de la My\u00e9line et Neuro\u2010inflammation Lyon University Hospital  Lyon France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3855-5135","authenticated-orcid":false,"given":"Sergio","family":"Ferrari","sequence":"additional","affiliation":[{"name":"Neurology Unit Department of Neurosciences, Biomedicine, and Movement Sciences University of Verona  Verona Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,3,14]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/WCO.0000000000000681"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00415-017-8635-4"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12974-016-0718-0"},{"key":"e_1_2_9_5_1","first-page":"6658000","article-title":"Two paediatric patients with encephalopathy and concurrent COVID\u201019 infection: two sides of the same coin?","volume":"2021","author":"Vraka K","year":"2021","journal-title":"Case Rep Neurol 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