{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,3]],"date-time":"2026-11-03T07:46:55Z","timestamp":1793692015075,"version":"4.5.1"},"reference-count":46,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2022,3,23]],"date-time":"2022-03-23T00:00:00Z","timestamp":1647993600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Euro J of Neurology"],"published-print":{"date-parts":[[2022,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and purpose<\/jats:title><jats:p>Neurological sequelae from coronavirus disease 2019 (COVID\u201019)\u00a0may persist after recovery from acute infection. Here, the aim was to describe the natural history of neurological manifestations over 1\u00a0year after COVID\u201019.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A prospective, multicentre, longitudinal cohort study in COVID\u201019\u00a0survivors was performed. At a 3\u2010month and 1\u2010year follow\u2010up, patients were assessed for neurological impairments by a neurological examination and a standardized test battery including the assessment of hyposmia (16\u2010item Sniffin' Sticks test), cognitive deficits (Montreal Cognitive Assessment &lt; 26) and mental health (Hospital Anxiety and Depression Scale and Post\u2010traumatic Stress Disorder Checklist 5).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Eighty\u2010one patients were evaluated 1\u00a0year after COVID\u201019, out of which 76 (94%) patients completed a 3\u2010month and 1\u2010year follow\u2010up. Patients were 54 (47\u201364) years old and 59% were male. New and persistent neurological disorders were found in 15% (3 months) and 12% (10\/81; 1 year). Symptoms at 1\u2010year follow\u2010up were reported by 48\/81 (59%) patients, including fatigue (38%), concentration difficulties (25%), forgetfulness (25%), sleep disturbances (22%), myalgia (17%), limb weakness (17%), headache (16%), impaired sensation (16%) and hyposmia (15%). Neurological examination revealed findings in 52\/81 (64%) patients without improvement over time (3 months, 61%, <jats:italic>p<\/jats:italic>\u00a0=\u00a00.230) including objective hyposmia (Sniffin' Sticks test &lt;13; 51%). Cognitive deficits were apparent in 18%, whereas signs of depression, anxiety and post\u2010traumatic stress disorders were found in 6%, 29% and 10% respectively 1\u00a0year after infection. These mental and cognitive disorders had not improved after the 3\u2010month follow\u2010up (all <jats:italic>p<\/jats:italic>\u00a0&gt;\u00a00.05).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Our data indicate that a significant patient number still suffer from neurological sequelae including neuropsychiatric symptoms 1\u00a0year after COVID\u201019\u00a0calling for interdisciplinary management of these patients.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ene.15307","type":"journal-article","created":{"date-parts":[[2022,3,3]],"date-time":"2022-03-03T16:40:19Z","timestamp":1646325619000},"page":"1685-1696","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":106,"title":["Neurological outcomes 1\u00a0year after COVID\u201019 diagnosis: A prospective longitudinal cohort 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