{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T13:29:30Z","timestamp":1789651770073,"version":"4.0.0"},"reference-count":50,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2022,3,13]],"date-time":"2022-03-13T00:00:00Z","timestamp":1647129600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100012686","name":"Deutsche Stiftung Neurologie","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100012686","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["EXC 2145 SyN"],"award-info":[{"award-number":["EXC 2145 SyN"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Euro J of Neurology"],"published-print":{"date-parts":[[2022,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and purpose<\/jats:title><jats:p>Recently, the Classification Committee of the B\u00e1r\u00e1ny Society defined the new syndrome of \"presbyvestibulopathy\" for elderly patients with chronic vestibular symptoms due to a mild bilateral peripheral vestibular hypofunction. However, control of stance and gait requires multiple functioning systems, for example, the somatosensory, visual, auditory, musculoskeletal, and cardio\u2010 and cerebrovascular systems. The aim of this cross\u2010sectional database\u2010driven study was to evaluate the frequency and characteristics of presbyvestibulopathy and additional gait\u2010relevant comorbidities.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In total, 707 patients aged \u226560\u00a0years with chronic vertigo\/dizziness were admitted to our tertiary hospital and received detailed neurological, neuro\u2010orthoptic, and laboratory audiovestibular examination. Medical history, comorbidities, functional impairment, and quality of life (Dizziness Handicap Inventory [DHI], European Quality of Life Scale, Vestibular Activities and Participation) were compared between presbyvestibulopathy and bilateral vestibulopathy in a matched\u2010paired study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In 95.5% of patients, complaints were better accounted for by another vestibular, neurological, cardiac, or psychiatric disease, and 32 patients (4.5%) met the diagnostic criteria for presbyvestibulopathy. Of these 32 patients, the majority showed further relevant comorbidities in other sensorimotor systems. Only one patient of 707 had \u201cisolated\u201d presbyvestibulopathy (0.14%). The mean total DHI scores indicated lower moderate impairment in presbyvestibulopathy than in bilateral vestibulopathy (40.6 vs. 49.0), which was confirmed by significant differences in the matched\u2010paired analysis (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Isolated presbyvestibulopathy is a very rare entity. It is regularly accompanied by other multisensory dysfunctions. These results indicate a potential role of mild vestibular hypofunction as a cofactor in multifactorial impairment. Thus, patients should be treated in an interdisciplinary setting with an awareness of diverse comorbidities.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ene.15308","type":"journal-article","created":{"date-parts":[[2022,3,3]],"date-time":"2022-03-03T16:44:15Z","timestamp":1646325855000},"page":"1825-1835","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["Chronic vestibular syndromes in the elderly: Presbyvestibulopathy\u2014an isolated clinical entity?"],"prefix":"10.1111","volume":"29","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7098-4744","authenticated-orcid":false,"given":"Katharina Johanna","family":"M\u00fcller","sequence":"first","affiliation":[{"name":"Department of Neurology University Hospital Ludwig Maximilian University of Munich  Munich Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandra","family":"Becker\u2010Bense","sequence":"additional","affiliation":[{"name":"German Center for Vertigo and Balance Disorders University Hospital Ludwig Maximilian University of Munich  Munich Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ralf","family":"Strobl","sequence":"additional","affiliation":[{"name":"German Center for Vertigo and Balance Disorders University Hospital Ludwig Maximilian University of Munich  Munich Germany"},{"name":"Institute for Medical Information Processing, Biometry, and Epidemiology Ludwig Maximilian University of Munich  Munich Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eva","family":"Grill","sequence":"additional","affiliation":[{"name":"German Center for Vertigo and Balance Disorders University Hospital Ludwig Maximilian University of Munich  Munich Germany"},{"name":"Institute for Medical Information Processing, Biometry, and Epidemiology Ludwig Maximilian University of Munich  Munich Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marianne","family":"Dieterich","sequence":"additional","affiliation":[{"name":"Department of Neurology University Hospital Ludwig Maximilian University of Munich  Munich Germany"},{"name":"German Center for Vertigo and Balance Disorders University Hospital Ludwig Maximilian University of Munich  Munich Germany"},{"name":"Munich Cluster for Systems Neurology  Munich Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,3,13]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/ageing\/afl084"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749\u20106632.2001.tb03747.x"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/jgs.13609"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1001\/archinternmed.2009.66"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.60.6.835"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1177\/00034894790880S201"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2021.680856"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.3233\/VES-1997-7107"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/0022\u2010510X(86)90176\u20100"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/ejn.13755"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00429\u2010014\u20100983\u20106"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.3233\/VES\u2010190672"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.3233\/VES\u2010170619"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00391\u2010019\u201001561\u2010z"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2020.609928"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00405\u2010020\u201006414\u20109"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.otorri.2021.04.005"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2020.582038"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12877\u2010018\u20101019\u20105"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00415\u2010019\u201009514\u20107"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.3238\/arztebl.2018.083"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1186\/s42466\u2010020\u201000064\u20102"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2019.00172"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410360304"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749\u20106632.2009.03850.x"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0093086"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinph.2006.04.022"},{"key":"e_1_2_10_29_1","unstructured":"World Health Organization.World Report on Hearing.World Health Organization;2021. [cited 2022 February 11].https:\/\/apps.who.int\/iris\/handle\/10665\/339913"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.1001\/archotol.1990.01870040046011"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-94-007-7596-1_3"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.3233\/VES\u2010130474"},{"key":"e_1_2_10_33_1","doi-asserted-by":"publisher","DOI":"10.1177\/0272989X06290495"},{"key":"e_1_2_10_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.annepidem.2012.02.004"},{"key":"e_1_2_10_35_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-642-24963-1"},{"key":"e_1_2_10_36_1","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2012.00169"},{"key":"e_1_2_10_37_1","doi-asserted-by":"publisher","DOI":"10.1684\/pnv.2018.0768"},{"key":"e_1_2_10_38_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.65.5.743"},{"key":"e_1_2_10_39_1","doi-asserted-by":"publisher","DOI":"10.1891\/cmaj.5.1.35.61260"},{"key":"e_1_2_10_40_1","doi-asserted-by":"publisher","DOI":"10.3389\/fpsyg.2020.570339"},{"key":"e_1_2_10_41_1","doi-asserted-by":"publisher","DOI":"10.3233\/VES\u2010160599"},{"key":"e_1_2_10_42_1","doi-asserted-by":"publisher","DOI":"10.3766\/jaaa.24.9.3"},{"key":"e_1_2_10_43_1","doi-asserted-by":"publisher","DOI":"10.1177\/1084713808325306"},{"key":"e_1_2_10_44_1","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2017.00258"},{"key":"e_1_2_10_45_1","doi-asserted-by":"publisher","DOI":"10.1055\/s\u20100040\u20101717124"},{"key":"e_1_2_10_46_1","doi-asserted-by":"publisher","DOI":"10.3233\/VES\u2010201522"},{"key":"e_1_2_10_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjoto.2021.103160"},{"issue":"2","key":"e_1_2_10_48_1","first-page":"133","article-title":"Senescence of human visual\u2010vestibular interactions. 1. Vestibulo\u2010ocular reflex and adaptive plasticity with aging","volume":"2","author":"Paige GD","year":"1992","journal-title":"J Vestib Res"},{"key":"e_1_2_10_49_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00415\u2010019\u201009351\u20108"},{"key":"e_1_2_10_50_1","doi-asserted-by":"publisher","DOI":"10.1097\/WCO.0000000000000771"},{"key":"e_1_2_10_51_1","doi-asserted-by":"publisher","DOI":"10.1097\/MAO.0b013e3181977e09"}],"container-title":["European Journal of Neurology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ene.15308","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/ene.15308","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ene.15308","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,24]],"date-time":"2023-08-24T10:13:23Z","timestamp":1692872003000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/ene.15308"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,3,13]]},"references-count":50,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2022,6]]}},"alternative-id":["10.1111\/ene.15308"],"URL":"https:\/\/doi.org\/10.1111\/ene.15308","archive":["Portico"],"relation":{},"ISSN":["1351-5101","1468-1331"],"issn-type":[{"value":"1351-5101","type":"print"},{"value":"1468-1331","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,3,13]]},"assertion":[{"value":"2021-12-31","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-02-14","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-03-13","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}