{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,19]],"date-time":"2026-06-19T20:46:24Z","timestamp":1781901984336,"version":"3.54.5"},"reference-count":15,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2022,3,30]],"date-time":"2022-03-30T00:00:00Z","timestamp":1648598400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000098","name":"NIH Clinical Center","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000098","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Euro J of Neurology"],"published-print":{"date-parts":[[2022,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Posterior cortical atrophy (PCA) is one of the atypical Alzheimer's disease variants, characterized by predominant visuospatial and visuoperceptual deficits, with established dorsal and ventral subtypes. A third primary occipital (caudal) variant has been suggested. We aimed to determine its demographics, clinical manifestations, and biomarker findings.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Fifty\u2010two PCA patients were investigated. Patients underwent neuropsychological assessment, magnetic resonance imaging, and fluorodeoxyglucose (FDG)\u2010, amyloid\u2010, and tau\u2010positron emission tomography (tau\u2010PET) scans. Normalized regional FDG\u2010PET values were represented as z\u2010scores relative to a control population. Patients were divided into \u201cprimary occipital\u201d and \u201cother PCA\u201d subgroups according to FDG\u2010PET\u2010defined criteria, with primary occipital defined as patients in which the z\u2010scores for occipital subregions were at least one standard deviation lower (SD) (i.e., more abnormal) than the z\u2010scores in all other brain regions. Global amyloid\u2010PET, temporo\u2010parietal FDG\u2010PET, and temporal tau\u2010PET regions\u2010of\u2010interest (ROIs) were calculated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Nine patients were classified as primary occipital; they were older (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.034) and had more years of education (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.007) than other PCA patients. The primary occipital group performed worse on the Ishihara test for color perception (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.001), while other PCA patients performed worse on the Western Aphasia Battery (WAB) praxis scale (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.005). Overall neuropsychiatric symptom burden was lower in the primary occipital group (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.001). The FDG\u2010PET meta\u2010ROI was higher in the primary occipital subtype (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.006), but no differences were observed in amyloid\u2010 and tau\u2010PET.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Our findings suggest that primary occipital PCA is characterized by an older age at onset, more color perception dysfunction, less severe ideomotor apraxia, and less hypometabolism in temporo\u2010parietal meta\u2010ROI compared to established phenotypes.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ene.15327","type":"journal-article","created":{"date-parts":[[2022,3,17]],"date-time":"2022-03-17T14:19:26Z","timestamp":1647526766000},"page":"2138-2143","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Posterior cortical atrophy: Primary occipital variant"],"prefix":"10.1111","volume":"29","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2811-3421","authenticated-orcid":false,"given":"Dror","family":"Shir","sequence":"first","affiliation":[{"name":"Department of Neurology Mayo Clinic  Rochester Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan","family":"Graff\u2010Radford","sequence":"additional","affiliation":[{"name":"Department of Neurology Mayo Clinic  Rochester Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mary M.","family":"Machulda","sequence":"additional","affiliation":[{"name":"Psychiatry and Psychology (Neuropsychology) Mayo Clinic  Rochester Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nha Trang Thu","family":"Pham","sequence":"additional","affiliation":[{"name":"Department of Radiology Mayo Clinic  Rochester Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"Jr.","given":"Clifford R.","family":"Jack","sequence":"additional","affiliation":[{"name":"Department of Radiology Mayo Clinic  Rochester Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Val J.","family":"Lowe","sequence":"additional","affiliation":[{"name":"Department of Radiology Mayo Clinic  Rochester Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6914-1563","authenticated-orcid":false,"given":"Jennifer L.","family":"Whitwell","sequence":"additional","affiliation":[{"name":"Department of Radiology Mayo Clinic  Rochester Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2930-8634","authenticated-orcid":false,"given":"Keith A.","family":"Josephs","sequence":"additional","affiliation":[{"name":"Department of Neurology Mayo Clinic  Rochester Minnesota 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