{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,29]],"date-time":"2025-09-29T03:50:40Z","timestamp":1759117840975,"version":"3.40.5"},"reference-count":31,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2022,4,12]],"date-time":"2022-04-12T00:00:00Z","timestamp":1649721600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Euro J of Neurology"],"published-print":{"date-parts":[[2022,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The IL\u201033\/ST2 immune axis plays crucial roles in infection and immunity. A dysregulated IL\u201033\/ST2 axis can induce autoimmune reaction and inflammatory responses. Guillain\u2010Barr\u00e9 syndrome (GBS) is an acute peripheral neuropathy, mostly caused by post\u2010infection autoimmunity. The role of IL\u201033\/ST2 axis is not known in GBS. This study aimed to explore the role of IL\u201033\/ST2 axis in GBS.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Three single nucleotide polymorphisms (SNPs) of <jats:italic>Il33<\/jats:italic> gene (rs16924159, rs7044343, rs1342336) and three SNPs of <jats:italic>Il1rl1<\/jats:italic> gene (rs10192157, rs1041973, rs10206753) coding for suppressor of tumorigenicity 2 (ST2) were genotyped in 179 GBS patients and 186 healthy controls by TaqMan Allelic Discrimination Assay. Plasma levels of IL\u201033 and sST2 were measured in a subset of GBS patients (<jats:italic>n<\/jats:italic>\u00a0=\u00a080) and healthy controls (<jats:italic>n<\/jats:italic>\u00a0=\u00a080) by ELISA.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The frequencies of CC genotype of rs10192157 (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.043) and TT genotype of rs10206753 (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.036) SNPs of <jats:italic>Il1rl1<\/jats:italic> gene differed significantly between GBS patients and healthy controls. Gene\u2013gene interaction between <jats:italic>Il33<\/jats:italic> and <jats:italic>Il1rl1<\/jats:italic> genes also conferred significant risk for GBS. In addition, the plasma sST2 levels were significantly elevated in GBS patients compared to healthy subjects (24,934.31\u00a0\u00b1\u00a01.81\u00a0pg\/ml vs. 12,518.97\u00a0\u00b1\u00a01.51\u00a0pg\/ml, <jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.001). Plasma sST2 levels showed a significant correlation with the disability scores at the peak of neurological deficit in GBS patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The IL\u201033\/ST2 axis is suggested to influence the immunopathogenesis of GBS. Genetic variants of <jats:italic>Il1rl1<\/jats:italic> gene might serve as a risk determinant of GBS and plasma sST2 levels might emerge as a biomarker of severity of GBS, if replicated further by other studies.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ene.15334","type":"journal-article","created":{"date-parts":[[2022,3,24]],"date-time":"2022-03-24T21:49:23Z","timestamp":1648158563000},"page":"2074-2083","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Role of altered IL\u201033\/ST2 immune axis in the immunobiology of Guillain\u2010Barr\u00e9 syndrome"],"prefix":"10.1111","volume":"29","author":[{"given":"Praveen P.","family":"Sharma","sequence":"first","affiliation":[{"name":"Department of Neurology National Institute of Mental Health and Neurosciences (NIMHANS)  Bangalore India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Doniparthi V.","family":"Seshagiri","sequence":"additional","affiliation":[{"name":"Department of Neurology National Institute of Mental Health and Neurosciences (NIMHANS)  Bangalore India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6682-4577","authenticated-orcid":false,"given":"Madhu","family":"Nagappa","sequence":"additional","affiliation":[{"name":"Department of Neurology National Institute of Mental Health and Neurosciences (NIMHANS)  Bangalore India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thrinath","family":"Mullapudi","sequence":"additional","affiliation":[{"name":"Department of Human Genetics National Institute of Mental Health and Neurosciences (NIMHANS)  Bangalore India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nikhitha","family":"Sreenivas","sequence":"additional","affiliation":[{"name":"Department of Human Genetics National Institute of Mental Health and Neurosciences (NIMHANS)  Bangalore India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Saikat","family":"Dey","sequence":"additional","affiliation":[{"name":"Department of Human Genetics National Institute of Mental Health and Neurosciences (NIMHANS)  Bangalore India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sumanth","family":"Shivaram","sequence":"additional","affiliation":[{"name":"Department of Neurology National Institute of Mental Health and Neurosciences (NIMHANS)  Bangalore India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rahul","family":"Wahatule","sequence":"additional","affiliation":[{"name":"Department of Neurology National Institute of Mental Health and Neurosciences (NIMHANS)  Bangalore India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vijay","family":"Kumawat","sequence":"additional","affiliation":[{"name":"Department of Transfusion Medicine and Haematology National Institute of Mental Health and Neurosciences (NIMHANS)  Bangalore India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Binu V.","family":"Sreekumaran Nair","sequence":"additional","affiliation":[{"name":"Department of Biostatistics National Institute of Mental Health and Neurosciences (NIMHANS)  Bangalore India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sriganesh","family":"Kamath","sequence":"additional","affiliation":[{"name":"Department of Neuroanaesthesia and Neurocritical Care National Institute of Mental Health and Neurosciences (NIMHANS)  Bangalore India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sanjib","family":"Sinha","sequence":"additional","affiliation":[{"name":"Department of Neurology National Institute of Mental Health and Neurosciences (NIMHANS)  Bangalore India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arun B.","family":"Taly","sequence":"additional","affiliation":[{"name":"Department of Neurology National Institute of Mental Health and Neurosciences (NIMHANS)  Bangalore India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5843-072X","authenticated-orcid":false,"given":"Monojit","family":"Debnath","sequence":"additional","affiliation":[{"name":"Department of Human Genetics National Institute of Mental Health and Neurosciences (NIMHANS)  Bangalore India"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,4,12]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(16)00339-1"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41582-019-0250-9"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2019.00717"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/sji.12201"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cyto.2018.04.026"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jocn.2020.03.010"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1212\/NXI.0000000000001031"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1155\/2015\/564098"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0003331"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2005.09.015"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1093\/intimm\/dxn060"},{"key":"e_1_2_9_13_1","first-page":"1295","article-title":"The IL33\/ST2 axis in Sjogren syndrome in relation to disease activity","volume":"20","author":"Margiotta DP","year":"2016","journal-title":"Eur Rev Med Pharmacol Sci"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1710401115"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2014.12.005"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410270707"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awt285"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(07)70130-8"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/121.4.767"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/jns.12204"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/mus.27071"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410440512"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0168828"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.imlet.2018.11.005"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep23806"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI67119"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0062144"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2009.09.007"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1093\/cvr\/cvq104"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cyto.2007.11.001"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1038\/mi.2017.32"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1215418"}],"container-title":["European Journal of Neurology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ene.15334","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/ene.15334","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ene.15334","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,22]],"date-time":"2023-08-22T20:49:19Z","timestamp":1692737359000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/ene.15334"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,4,12]]},"references-count":31,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2022,7]]}},"alternative-id":["10.1111\/ene.15334"],"URL":"https:\/\/doi.org\/10.1111\/ene.15334","archive":["Portico"],"relation":{},"ISSN":["1351-5101","1468-1331"],"issn-type":[{"type":"print","value":"1351-5101"},{"type":"electronic","value":"1468-1331"}],"subject":[],"published":{"date-parts":[[2022,4,12]]},"assertion":[{"value":"2022-02-19","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-03-17","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-04-12","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}