{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,16]],"date-time":"2026-06-16T07:20:21Z","timestamp":1781594421235,"version":"3.54.5"},"reference-count":25,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2022,4,11]],"date-time":"2022-04-11T00:00:00Z","timestamp":1649635200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81560053"],"award-info":[{"award-number":["81560053"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82060054"],"award-info":[{"award-number":["82060054"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Euro J of Neurology"],"published-print":{"date-parts":[[2022,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and purpose<\/jats:title><jats:p>To explore the relationship between baseline levels of matrix metalloproteinase 9 (MMP9) in peripheral blood and the outcomes in patients with acute minor stroke and transient ischemic attack (TIA).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We assessed data from patients with acute minor ischemic stroke or TIA who were included in the CHANCE (Clopidogrel in High\u2010Risk Patients with Acute Nondisabling Cerebrovascular Events) trial. Baseline level of MMP9 in peripheral blood is classified into five quintiles. We assessed the relationship between the baseline MMP9 and outcomes of stroke recurrence, composite vascular events, and poor functional outcomes within 90\u00a0days after stroke onset.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of the 3014 patients included, 295 (9.79%) had recurrent stroke, 289 (9.59%) had recurrent ischemic stroke, 297 (9.85%) had combined vascular events, and 199 (6.64%) had poor functional outcomes within 90\u00a0days. We used MMP9 concentrations near hazard ratio (HR)\u00a0=\u00a01 (Q3) in restricted cubic splines as the reference. The result showed that, compared to patients in the Q3\u00a0group, patients in the highest quintile (Q5\u00a0group) had an increased risk of poor functional outcomes at 90\u00a0days after adjusting the risk factors and confounders (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.030), which may be associated with an increased risk of combined vascular events (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.052). Using Cox regression models or logistic regression models with restricted cubic spline, we also observed that higher MMP9 ratios were associated with an increased risk of stroke recurrence, combined events, and poor functional outcomes at a range of concentrations.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>For patients with acute minor stroke or TIA, higher baseline MMP9\u00a0level was associated with an increased risk of poor functional outcomes, which might be related to stroke recurrence and combined vascular events.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ene.15342","type":"journal-article","created":{"date-parts":[[2022,3,31]],"date-time":"2022-03-31T15:42:31Z","timestamp":1648741351000},"page":"2976-2986","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Predictive values of baseline matrix metalloproteinase 9 levels in peripheral blood on 3\u2010month outcomes of high\u2010risk patients with minor stroke or transient ischemic attack"],"prefix":"10.1111","volume":"29","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6441-9917","authenticated-orcid":false,"given":"Min","family":"Zhang","sequence":"first","affiliation":[{"name":"China National Clinical Research Center for Neurological Disease Beijing Tiantan Hospital Capital Medical University  Beijing China"},{"name":"National Health Commission Key Laboratory of Prevention and Treatment of Central Asia High Incidence Diseases Department of Pathology and Key Laboratory for Xinjiang Endemic and Ethnic Diseases Shihezi University School of Medicine  Shihezi Xinjiang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xia","family":"Meng","sequence":"additional","affiliation":[{"name":"China National Clinical Research Center for Neurological Disease Beijing Tiantan Hospital Capital Medical University  Beijing China"},{"name":"Department of Neurology Beijing Tiantan Hospital Capital Medical 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Clinical Research Center for Neurological Disease Beijing Tiantan Hospital Capital Medical University  Beijing China"},{"name":"Department of Neurology Beijing Tiantan Hospital Capital Medical University  Beijing China"},{"name":"Center of Stroke Beijing Institute for Brain Disorders  Beijing China"},{"name":"Beijing Key Laboratory of Translational Medicine for Cerebrovascular Disease  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongyi","family":"Yan","sequence":"additional","affiliation":[{"name":"China National Clinical Research Center for Neurological Disease Beijing Tiantan Hospital Capital Medical University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiangrong","family":"Liu","sequence":"additional","affiliation":[{"name":"China National Clinical Research Center for Neurological Disease Beijing Tiantan Hospital Capital Medical University  Beijing 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