{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T16:08:36Z","timestamp":1791994116285,"version":"4.4.0"},"reference-count":18,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2022,4,15]],"date-time":"2022-04-15T00:00:00Z","timestamp":1649980800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Euro J of Neurology"],"published-print":{"date-parts":[[2022,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background and purpose<\/jats:title>\n                    <jats:p>Oropharyngeal dysphagia is generally recognized to increase the risk of malnutrition; however, its role in patients with neurodegenerative disease has yet to be determined. This cross\u2010sectional study aimed to investigate the impact of swallowing function on malnutrition risk in patients with neurodegenerative diseases.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Patients with oral nutrition and diagnosis of Huntington disease (HD), Parkinson disease (PD), or amyotrophic lateral sclerosis (ALS) were recruited. Demographic and clinical data were collected. The swallowing assessment included a fiberoptic endoscopic evaluation of swallowing, an oral phase assessment, and a meal observation scored with the Mealtime Assessment Scale (MAS). Malnutrition risk was assessed with the Mini Nutritional Assessment.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Overall, 148 patients were recruited (54 HD, 33 PD, and 61 ALS). One hundred (67.6%) patients were considered at risk of malnutrition. In the multivariate analysis, age \u2265 65 years (odds ratio [OR] = 3.16,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.014), disease severity (moderate vs mild OR = 3.89, severe vs mild OR = 9.71,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.003), number of masticatory cycles (OR = 1.03,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.044), and MAS safety (OR = 1.44,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.016) were significantly associated with malnutrition risk.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Prolonged oral phase and signs of impaired swallowing safety during meals, together with older age and disease severity, are independent predictors of malnutrition risk in neurodegenerative diseases. This study broadens the focus on dysphagia, stressing the importance of early detection not only of pharyngeal signs, but also of oral phase impairment and meal difficulties through a multidimensional swallowing assessment.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/ene.15345","type":"journal-article","created":{"date-parts":[[2022,4,6]],"date-time":"2022-04-06T03:03:03Z","timestamp":1649214183000},"page":"2493-2498","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Predictors of malnutrition risk in neurodegenerative diseases: The role of swallowing function"],"prefix":"10.1111","volume":"29","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3939-0742","authenticated-orcid":false,"given":"Nicole","family":"Pizzorni","sequence":"first","affiliation":[{"name":"Department of Biomedical and Clinical Sciences \u201cLuigi Sacco\u201d Universit\u00e0 degli Studi di Milano  Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Ciammola","sequence":"additional","affiliation":[{"name":"Department of Neurology and Laboratory of Neuroscience Istituto Auxologico Italiano IRCCS  Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giovanni","family":"Casazza","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences and Community Health Universit\u00e0 degli Studi di Milano  Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniela","family":"Ginocchio","sequence":"additional","affiliation":[{"name":"Amyotrophic Lateral Sclerosis Center Maugeri Scientific Clinical Institutes, Scientific Institute for Research and Health Care  Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Federica","family":"Bianchi","sequence":"additional","affiliation":[{"name":"Amyotrophic Lateral Sclerosis Center Maugeri Scientific Clinical Institutes, Scientific Institute for Research and Health Care  Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah","family":"Feroldi","sequence":"additional","affiliation":[{"name":"Amyotrophic Lateral Sclerosis Center Maugeri Scientific Clinical Institutes, Scientific Institute for Research and Health Care  Milan Italy"},{"name":"PhD Program in Neuroscience School of Medicine and Surgery University Milan\u2010Bicocca  Monza Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barbara","family":"Poletti","sequence":"additional","affiliation":[{"name":"Department of Neurology and Laboratory of Neuroscience Istituto Auxologico Italiano IRCCS  Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lorenzo","family":"Nanetti","sequence":"additional","affiliation":[{"name":"Department of Diagnostics and Technology Unit of Medical Genetics and Neurogenetics Carlo Besta Neurological Institute, Scientific Institute for Research and Health Care Foundation  Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caterina","family":"Mariotti","sequence":"additional","affiliation":[{"name":"Department of Diagnostics and Technology Unit of Medical Genetics and Neurogenetics Carlo Besta Neurological Institute, Scientific Institute for Research and Health Care Foundation  Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriele","family":"Mora","sequence":"additional","affiliation":[{"name":"Amyotrophic Lateral Sclerosis Center Maugeri Scientific Clinical Institutes, Scientific Institute for Research and Health Care  Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio","family":"Schindler","sequence":"additional","affiliation":[{"name":"Department of Biomedical and Clinical Sciences \u201cLuigi Sacco\u201d Universit\u00e0 degli Studi di Milano  Milan 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