{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,20]],"date-time":"2026-03-20T11:22:24Z","timestamp":1774005744512,"version":"3.50.1"},"reference-count":14,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2022,4,17]],"date-time":"2022-04-17T00:00:00Z","timestamp":1650153600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Euro J of Neurology"],"published-print":{"date-parts":[[2022,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and purpose<\/jats:title><jats:p>During the COVID\u201019 pandemic, myasthenia gravis (MG) patients have been identified as subjects at high risk of developing severe COVID\u201019, and thus were offered vaccination with priority. The lack of direct data on the safety and tolerability of SARS\u2010CoV\u20102 vaccines in MG have contributed to vaccine hesitancy. To address this issue, the safety and tolerability of SARS\u2010CoV\u20102 vaccines were assessed in a large cohort of MG patients from two referral centers.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Patients with confirmed MG diagnosis, consecutively seen between October and December 2021 at two MG centers, were enrolled. Demographics, clinical characteristics, and information regarding SARS\u2010CoV\u20102 infection\/vaccination were extracted from medical reports and\/or collected throughout telephonic or in\u2010person interviews.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Ninety\u2010eight (94.2%) of 104 patients included were administered at least two vaccine doses 4\u00a0weeks before the interview or earlier, and among them, 63 of 98 (64.2%) have already received the \u201cbooster\u201d dose. The most frequently used vaccines were BNT162b2\u2010Pfizer\u2010BioNTech and mRNA\u20101273\u2010Moderna. Overall, only minor side effects were reported, most commonly local pain and fever. MG worsening after vaccination was observed in eight of 104 (7.7%) cases. The frequency of worsening among muscle\u2010specific tyrosine kinase MG cases (3\/9, 33.3%) was significantly higher compared to other serological subgroups. Spontaneous symptom regression was observed in six of eight cases. Twelve of 104 (11.5%) patients had SARS\u2010CoV\u20102 infection, and none of the SARS\u2010CoV\u20102\u2010infected MG patients worsened after vaccination.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Our data support the safety and tolerability of mRNA COVID\u201019 vaccines, which should be strongly recommended in MG patients, who could be at higher risk of complications if exposed to SARS\u2010CoV\u20102 infection.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ene.15348","type":"journal-article","created":{"date-parts":[[2022,4,7]],"date-time":"2022-04-07T18:29:25Z","timestamp":1649356165000},"page":"2505-2510","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":31,"title":["Safety and tolerability of SARS\u2010Cov\u20102 vaccination in patients with myasthenia gravis: A multicenter experience"],"prefix":"10.1111","volume":"29","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5551-0185","authenticated-orcid":false,"given":"Antonio","family":"Farina","sequence":"first","affiliation":[{"name":"Department of Neurosciences, Drugs, and Child Health University of Florence  Florence Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Silvia","family":"Falso","sequence":"additional","affiliation":[{"name":"Department of Neuroscience Catholic University of the Sacred Heart  Rome Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sara","family":"Cornacchini","sequence":"additional","affiliation":[{"name":"Department of Neurosciences, Drugs, and Child Health University of Florence  Florence Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gregorio","family":"Spagni","sequence":"additional","affiliation":[{"name":"Department of Neuroscience Catholic University of the Sacred Heart  Rome Italy"},{"name":"Neurology Unit Fondazione Policlinico Universitario \u201cA. Gemelli\u201d IRCCS  Rome Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4763-7784","authenticated-orcid":false,"given":"Gabriele","family":"Monte","sequence":"additional","affiliation":[{"name":"Department of Neuroscience Catholic University of the Sacred Heart  Rome Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1869-7067","authenticated-orcid":false,"given":"Alice","family":"Mariottini","sequence":"additional","affiliation":[{"name":"Department of Neurosciences, Drugs, and Child Health University of Florence  Florence Italy"},{"name":"Department of Neurology 2 Careggi University Hospital  Florence Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luca","family":"Massacesi","sequence":"additional","affiliation":[{"name":"Department of Neurosciences, Drugs, and Child Health University of Florence  Florence Italy"},{"name":"Department of Neurology 2 Careggi University Hospital  Florence Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alessandro","family":"Barilaro","sequence":"additional","affiliation":[{"name":"Department of Neurology 2 Careggi University Hospital  Florence Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amelia","family":"Evoli","sequence":"additional","affiliation":[{"name":"Department of Neuroscience Catholic University of the Sacred Heart  Rome Italy"},{"name":"Neurology Unit Fondazione Policlinico Universitario \u201cA. Gemelli\u201d IRCCS  Rome Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1740-4522","authenticated-orcid":false,"given":"Valentina","family":"Damato","sequence":"additional","affiliation":[{"name":"Department of Neurosciences, Drugs, and Child Health University of Florence  Florence Italy"},{"name":"Department of Neurology 2 Careggi University Hospital  Florence Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,4,17]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1080\/1744666x.2021.1936500"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00415\u2010018\u20108751\u20109"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrrheum.2014.206"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2019.01.007"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2021.733418"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1212\/wnl.55.1.16"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1212\/wnl.0000000000002790"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clineuro.2020.106045"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jns.2020.116803"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/mus.27179"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.3390\/vaccines9101112"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/s1473\u20103099(21)00224\u20103"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/nyas.13535"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/ene.14951"}],"container-title":["European Journal of Neurology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ene.15348","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/ene.15348","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ene.15348","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,23]],"date-time":"2023-08-23T17:21:17Z","timestamp":1692811277000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/ene.15348"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,4,17]]},"references-count":14,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2022,8]]}},"alternative-id":["10.1111\/ene.15348"],"URL":"https:\/\/doi.org\/10.1111\/ene.15348","archive":["Portico"],"relation":{},"ISSN":["1351-5101","1468-1331"],"issn-type":[{"value":"1351-5101","type":"print"},{"value":"1468-1331","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,4,17]]},"assertion":[{"value":"2022-01-20","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-03-30","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-04-17","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}