{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T16:12:03Z","timestamp":1773331923455,"version":"3.50.1"},"reference-count":36,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2022,4,19]],"date-time":"2022-04-19T00:00:00Z","timestamp":1650326400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100009910","name":"Hartmann Fonden","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100009910","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Euro J of Neurology"],"published-print":{"date-parts":[[2022,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and purpose<\/jats:title><jats:p>The Faroe Islands are a geographically isolated population in the North Atlantic with a similar prevalence of Alzheimer's disease (AD) and all\u2010cause dementia as other European populations. However, the genetic risk underlying AD and other dementia susceptibility has yet to be elucidated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Forty\u2010nine single\u2010nucleotide polymorphisms (SNPs) were genotyped in 174 patients with AD and other dementias and 159 healthy controls. Single variant and polygenic risk score (PRS) associations, with\/without <jats:italic>APOE<\/jats:italic> variability, were assessed by logistic regression. Performance was examined using receiver operating characteristic area under the curve (ROC AUC) analysis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p><jats:italic>APOE<\/jats:italic>rs429358 was associated with AD in the Faroese cohort after correction for multiple testing (odds ratio [OR]\u00a06.32, 95% confidence interval [CI] 3.98\u201310.05, <jats:italic>p<\/jats:italic>\u00a0=\u00a06.31e<jats:sup>\u221215<\/jats:sup>), with suggestive evidence for three other variants: <jats:italic>NECTIN2<\/jats:italic> rs41289512 (OR 2.05, 95% CI 1.20\u20133.51, <jats:italic>p<\/jats:italic>\u00a0=\u00a00.01), <jats:italic>HLA\u2010DRB1<\/jats:italic> rs6931277 (OR 0.67, 95% CI 0.48\u20130.94, <jats:italic>p<\/jats:italic>\u00a0=\u00a00.02) and <jats:italic>APOE<\/jats:italic> rs7412 [\u03b52] (OR 0.28, 95% CI 0.11\u20130.73, <jats:italic>p<\/jats:italic>\u00a0=\u00a00.01). PRSs were associated with AD with or without the inclusion of <jats:italic>APOE<\/jats:italic> (PRS<jats:sup>+APOE<\/jats:sup> OR\u00a0=\u00a04.5, 95% CI 2.90\u20135.85, <jats:italic>p<\/jats:italic>\u00a0=\u00a04.56e<jats:sup>\u221215<\/jats:sup>, and PRS<jats:sup>\u2212APOE<\/jats:sup> OR\u00a0=\u00a01.53, 95% CI 1.21\u20131.98, <jats:italic>p<\/jats:italic>\u00a0=\u00a06.82e<jats:sup>\u22124<\/jats:sup>). AD ROC AUC analyses demonstrated a PRS<jats:sup>+APOE<\/jats:sup> AUC\u00a0=\u00a080.3% and PRS<jats:sup>\u2212APOE<\/jats:sup> AUC\u00a0=\u00a063.4%. However, PRS<jats:sup>+APOE<\/jats:sup> was also significantly associated with all\u2010cause dementia (OR\u00a0=\u00a03.39, 95% CI 2.51\u20134.71, <jats:italic>p<\/jats:italic>\u00a0=\u00a02.50e<jats:sup>\u221214<\/jats:sup>) with an AUC\u00a0=\u00a076.9%, that is, all\u2010cause dementia showed similar results albeit less significant.<\/jats:p><\/jats:sec><jats:sec><jats:title>Discussion<\/jats:title><jats:p>In the Faroe Islands, SNP analyses highlighted <jats:italic>APOE<\/jats:italic> and immunogenomic variability in AD and dementia risk. PRS<jats:sup>+APOE<\/jats:sup>, based on 25 SNPs\/loci, had excellent sensitivity and specificity for AD with an AUC of 80.3%. High PRSs were also associated with an earlier onset of late\u2010onset AD.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ene.15351","type":"journal-article","created":{"date-parts":[[2022,4,6]],"date-time":"2022-04-06T07:27:45Z","timestamp":1649230065000},"page":"2192-2200","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Polygenic risk of Alzheimer's disease in the Faroe Islands"],"prefix":"10.1111","volume":"29","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4663-6210","authenticated-orcid":false,"given":"Malan","family":"Johansen","sequence":"first","affiliation":[{"name":"Center of Health Science University of the Faroe Islands  T\u00f3rshavn Faroe Islands"},{"name":"Department of Occupational Medicine and Public Health Faroese Hospital System  T\u00f3rshavn Faroe 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