{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,11]],"date-time":"2026-02-11T18:53:13Z","timestamp":1770835993652,"version":"3.50.1"},"reference-count":24,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2022,4,30]],"date-time":"2022-04-30T00:00:00Z","timestamp":1651276800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Euro J of Neurology"],"published-print":{"date-parts":[[2022,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and purpose<\/jats:title><jats:p>This study was undertaken to investigate short\u2010 and long\u2010term outcome following thymectomy in patients with acetylcholine receptor antibody (AChR\u2010Ab)\u2010positive myasthenia gravis (MG).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Rates of clinical response (defined as minimal manifestation, pharmacological remission, or complete stable remission) lasting for at least 1\u00a0year were retrospectively analyzed using Cox proportional hazard models. The occurrence of relapses was recorded during follow\u2010up. Clinical factors associated with achieving an initial or a sustained response were analyzed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Ninety\u2010four patients with a median age of 33\u00a0years (interquartile range [IQR]\u00a0=\u00a022\u201351), 68% with nonthymomatous MG and 32% with thymoma\u2010associated MG, were included. An initial clinical response was reached in 72% (68\/94). Neither sex, age at onset, thymus histology, delay to surgery after disease onset, surgical approach, corticosteroid treatment, nor clinical severity before thymectomy was significantly associated with achieving this endpoint. During long\u2010term follow\u2010up (median\u00a0=\u00a089.5\u00a0months, IQR\u00a0=\u00a046\u2013189.5), only half of the patients with an initial response (34\/68) had a sustained response without relapses. No clinical factors predicted whether the response would become sustained. In patients without immunosuppressive treatment before thymectomy (<jats:italic>n<\/jats:italic>\u00a0=\u00a024), a high AChR\u2010Ab reduction rate after thymectomy was associated with a higher likelihood of achieving an initial response (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.03).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Sustained long\u2010term clinical response of MG patients after thymectomy is significantly lower than the initial response rates would suggest. The observation that none of the evaluated clinical factors was associated with a worse outcome supports the current clinical practice of patient selection for thymectomy. The relative decline of AChR\u2010Abs after surgery appears to be a promising prognostic marker.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ene.15362","type":"journal-article","created":{"date-parts":[[2022,4,18]],"date-time":"2022-04-18T09:14:50Z","timestamp":1650273290000},"page":"2453-2462","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Short\u2010term and sustained clinical response following thymectomy in patients with myasthenia gravis"],"prefix":"10.1111","volume":"29","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6581-4572","authenticated-orcid":false,"given":"Jakob","family":"Rath","sequence":"first","affiliation":[{"name":"Department of Neurology Medical University of Vienna  Vienna Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Manuela","family":"Taborsky","sequence":"additional","affiliation":[{"name":"Department of Neurology Medical University of Vienna  Vienna 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