{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,5]],"date-time":"2026-01-05T21:44:43Z","timestamp":1767649483118,"version":"3.40.5"},"reference-count":27,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2022,5,9]],"date-time":"2022-05-09T00:00:00Z","timestamp":1652054400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Euro J of Neurology"],"published-print":{"date-parts":[[2022,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and purpose<\/jats:title><jats:p>Chronic migraine is a highly disabling primary headache disorder that is the most common diagnosis of patients seen at tertiary headache centres. Typical oral preventive therapies are associated with many limitations that impact their therapeutic utility. Erenumab was the first available calcitonin gene\u2010related peptide monoclonal antibody in the UK. It had proven efficacy in migraine prevention in clinical trials and limited real\u2010world data in tertiary settings.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We audited our first 92 patients (<jats:italic>n<\/jats:italic>\u00a0=\u00a073 females) with severely disabling chronic migraine who were given monthly erenumab 70\u00a0mg sc for 6\u00a0months between December 2018 and December 2019.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>At 3\u00a0months, monthly migraine days were significantly reduced by a median of 4\u00a0days, and all other variables also showed significant improvement. The improvement was not affected by baseline analgesic use status. More than half of our patients experienced a clinically meaningful improvement in migraine days. No serious adverse events were reported.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Our real\u2010world data with erenumab demonstrate it is effective and well tolerated in managing patients with chronic migraine in a tertiary care setting.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ene.15364","type":"journal-article","created":{"date-parts":[[2022,4,21]],"date-time":"2022-04-21T07:13:53Z","timestamp":1650525233000},"page":"2473-2480","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Erenumab in chronic migraine: Experience from a UK tertiary centre and comparison with other real\u2010world evidence"],"prefix":"10.1111","volume":"29","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7178-4725","authenticated-orcid":false,"given":"Modar","family":"Khalil","sequence":"first","affiliation":[{"name":"National Institute for Health Research\u2013Wellcome Trust King\u2019s Clinical Research 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