{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T00:49:31Z","timestamp":1787014171619,"version":"build-2736575974"},"reference-count":35,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2022,5,10]],"date-time":"2022-05-10T00:00:00Z","timestamp":1652140800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81971213"],"award-info":[{"award-number":["81971213"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Euro J of Neurology"],"published-print":{"date-parts":[[2022,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background and purpose<\/jats:title>\n                    <jats:p>This study was undertaken to investigate the association between human leukocyte antigen (HLA) genotype and clinical characteristics of anti\u2010LGI1 encephalitis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>HLA genotyping was performed in 34 patients with anti\u2010LGI1 encephalitis admitted to West China Hospital between April 2014 and May 2021, as well as in 305 healthy controls. The online tool NetMHCIIpan 4.0 and AutoDock Vina software were used to predict binding between LGI1 peptide and HLA class II molecules.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Risk of anti\u2010LGI1 encephalitis was strongly associated with the DRB1*03:01 allele (odds ratio [OR]\u00a0=\u00a04.31, 95% confidence interval [CI]\u00a0=\u00a01.96\u20139.25, corrected\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a02.75\u00a0\u00d7\u00a010\n                      <jats:sup>\u22124<\/jats:sup>\n                      ) and the DRB1*03:01\u2010DQB1*02:01 haplotype (OR\u00a0=\u00a04.45, 95% CI\u00a0=\u00a02.02\u20139.59, corrected\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a02.94\u00a0\u00d7\u00a010\n                      <jats:sup>\u22124<\/jats:sup>\n                      ). Compared to carriers of the DRB1*07:01 allele, those with the DRB1*03:01 allele were more likely to be female (93.3% vs. 33.3%,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.004) and to be younger (median age\u00a0=\u00a038 vs. 65\u00a0years,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a00.001). DRB1*03:01 carriers showed stronger response to immunotherapy than carriers of the DRB1*07:01 allele, based on median score decrease on the modified Rankin scale (2, interquartile range\u00a0=\u00a01\u20132 vs. 1, interquartile range\u00a0=\u00a00\u20131;\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.03) at 4\u00a0weeks after immunotherapy. Prediction and docking algorithms suggested that the LGI1 peptide can bind to the DRB1*03:01 molecule strongly.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The strong association between anti\u2010LGI1 encephalitis and certain HLA class II alleles supports a primary autoimmune origin for the disease. Carriers of the DRB1*03:01 allele in Chinese patients with anti\u2010LGI1 encephalitis are more likely to be female, to suffer earlier disease onset, and to respond better to immunotherapy.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/ene.15376","type":"journal-article","created":{"date-parts":[[2022,4,30]],"date-time":"2022-04-30T03:09:49Z","timestamp":1651288189000},"page":"2367-2375","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["HLA\u2010DRB1*03:01 is associated with female sex and younger age of anti\u2010LGI1 encephalitis"],"prefix":"10.1111","volume":"29","author":[{"given":"Xu","family":"Liu","sequence":"first","affiliation":[{"name":"Department of Neurology West China Hospital Sichuan University  Chengdu China"},{"name":"Institute of Brain Science and Brain\u2010Inspired Technology, West China Hospital Sichuan University  Chengdu 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