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However, SC performance among ALS patients is heterogeneous due to the phenotypic variability of the disease and the wide range of neuropsychological tools employed. The aim of the present study was to assess facial emotion recognition and theory of mind in ALS patients compared to controls and to evaluate correlations with the other cognitive domains and degree of motor impairment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Eighty\u2010three patients and 42 controls underwent a cognitive evaluation and <jats:styled-content style=\"fixed-case\">SC<\/jats:styled-content> assessment through the Ekman 60 Faces Test (<jats:styled-content style=\"fixed-case\">EK\u201060F<\/jats:styled-content>), the Reading the Mind in the <jats:styled-content style=\"fixed-case\">Eyes Test\u201336 Faces<\/jats:styled-content> (<jats:styled-content style=\"fixed-case\">RMET<\/jats:styled-content>\u201036), and the <jats:styled-content style=\"fixed-case\">Story\u2010Based<\/jats:styled-content> Empathy Task (<jats:styled-content style=\"fixed-case\">SET<\/jats:styled-content>).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>ALS patients showed significantly worse performance compared to controls in EK\u201060F global score (<jats:italic>p<\/jats:italic>\u00a0&lt;\u20090.001),\u00a0recognition of disgust (<jats:italic>p<\/jats:italic> =\u20090.032), anger (<jats:italic>p<\/jats:italic> =\u20090.038), fear (<jats:italic>p<\/jats:italic>\u00a0&lt;\u20090.001), and sadness (<jats:italic>p<\/jats:italic>\u00a0&lt;\u20090.001); RMET\u201036 (<jats:italic>p<\/jats:italic>\u00a0&lt;\u20090.001), and SET global score (<jats:italic>p<\/jats:italic>\u00a0&lt;\u20090.001). Also, cognitively normal patients (ALS\u2010CN) showed significantly worse performance compared to controls in EK\u201060F global score (<jats:italic>p<\/jats:italic>\u00a0&lt;\u20090.001), recognition of fear (<jats:italic>p<\/jats:italic> =\u20090.002), sadness (<jats:italic>p<\/jats:italic>\u00a0&lt;\u20090.001), and SET (<jats:italic>p<\/jats:italic>\u00a0&lt;\u20090.001). RMET\u201036 showed a significant correlation with the Category Fluency Test (<jats:italic>p<\/jats:italic> =\u20090.041). SC tests showed no correlation with motor impairment expressed by Amyotrophic Lateral Sclerosis Functional Rating Scale\u2013Revised.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>ALS patients, also when categorized as ALS\u2010CN, may show impairment in SC performance. The frequent identification of early SC impairment in ALS patients supports the need to routinely assess SC for its impact on end\u2010of\u2010life decisions and its potential influence on patients' quality of life.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ene.15388","type":"journal-article","created":{"date-parts":[[2022,5,7]],"date-time":"2022-05-07T08:08:35Z","timestamp":1651910915000},"page":"2211-2219","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Social cognition deficits in amyotrophic lateral sclerosis: A pilot cross\u2010sectional population\u2010based study"],"prefix":"10.1111","volume":"29","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7070-2409","authenticated-orcid":false,"given":"Francesca","family":"Palumbo","sequence":"first","affiliation":[{"name":"\u201cRita Levi Montalcini\u201d Department of Neuroscience Amyotrophic Lateral Sclerosis Center, University of Turin  Turin 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