{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T11:02:46Z","timestamp":1789729366442,"version":"4.0.1"},"reference-count":41,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2022,5,31]],"date-time":"2022-05-31T00:00:00Z","timestamp":1653955200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Euro J of Neurology"],"published-print":{"date-parts":[[2022,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and purpose<\/jats:title><jats:p>Venous thromboembolic events (VTEs) are a major complication in cancer patients, and therefore, also in brain cancer patients, anticoagulants are considered appropriate in the treatment of VTEs.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Frequency, risk factors, and treatment of VTEs, as well as associated complications, were assessed in a population\u2010based cohort of glioblastoma patients in the Canton of Zurich, Switzerland. Correlations between clinical data and survival were retrospectively analyzed using the log\u2010rank test and Cox regression models.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Four hundred fourteen glioblastoma patients with isocitrate dehydrogenase wild\u2010type status were identified. VTEs were documented in 65 patients (15.7%). Median time from tumor diagnosis to the occurrence of a VTE was 1.8\u00a0months, and 27 patients were diagnosed with VTEs postoperatively (within 35\u2009days; 42.2%). History of a prior VTE was more common in patients who developed VTEs than in those who did not (<jats:italic>p<\/jats:italic>\u00a0=\u20090.004). Bevacizumab treatment at any time during the disease course was not associated with occurrence of VTEs (<jats:italic>p<\/jats:italic>\u00a0=\u20090.593). Most patients with VTEs (<jats:italic>n<\/jats:italic>\u00a0=\u200961, 93.8%) were treated with therapeutic anticoagulation. Complications occurred in 14 patients (23.0%), mainly intracranial hemorrhages (<jats:italic>n<\/jats:italic>\u00a0=\u20097, 11.5%). Overall survival did not differ between patients diagnosed with VTEs and those who had no VTE (<jats:italic>p<\/jats:italic>\u00a0=\u20090.139). Tumor progression was the major cause of death (<jats:italic>n<\/jats:italic>\u00a0=\u2009283, 90.7%), and only three patients (1.0%) died in association with acute VTEs.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Venous thromboembolic events occurred early in the disease course, suggesting that the implementation of primary venous thromboembolism prophylaxis during first\u2010line chemoradiotherapy could be explored in a randomized setting.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ene.15404","type":"journal-article","created":{"date-parts":[[2022,5,12]],"date-time":"2022-05-12T08:01:10Z","timestamp":1652342470000},"page":"2386-2397","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":27,"title":["Venous thromboembolic events in glioblastoma patients: An epidemiological 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