{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T07:48:26Z","timestamp":1782978506856,"version":"3.54.5"},"reference-count":31,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2022,6,17]],"date-time":"2022-06-17T00:00:00Z","timestamp":1655424000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Euro J of Neurology"],"published-print":{"date-parts":[[2022,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and purpose<\/jats:title><jats:p>Endovascular therapy (EVT) is increasingly reported for treatment of isolated posterior cerebral artery (PCA) occlusions although its clinical benefit remains uncertain. This study\u2010level meta\u2010analysis investigated the functional outcomes and safety of EVT and best medical management (BMM) compared to BMM alone for treatment of PCA occlusion stroke.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We conducted a literature search in PubMed, Web of Science and Embase for studies in patients with isolated PCA occlusion stroke treated with EVT\u2009+\u2009BMM or BMM including intravenous thrombolysis. There were no randomized trials and all studies were retrospective. The primary outcome was modified Rankin Scale score of 0\u20132 at 3\u00a0months, while safety outcomes included mortality rate and incidence of symptomatic intracranial hemorrhage (sICH).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Twelve studies with a total of 679 patients were included in the meta\u2010analysis: 338 patients with EVT\u2009+\u2009BMM and 341 patients receiving BMM alone. Good functional outcome at 3\u00a0months was achieved in 58.0% (95% confidence interval [CI] 43.83\u201370.95) of patients receiving EVT\u2009+\u2009BMM and 48.1% (95% CI 40.35\u201355.92) of patients who received BMM alone, with respective mortality rates of 12.6% (95% CI 7.30\u201320.93) and 12.3% (95% CI 8.64\u201317.33). sICH occurred in 4.2% (95% CI 2.47\u20137.03) of patients treated with EVT\u2009+\u2009BMM and 3.2% (95% CI 1.75\u20135.92) of patients treated with BMM alone. Comparative analyses were performed on studies that included both treatments and these demonstrated no significant differences.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Our results demonstrate that EVT represents a safe treatment for patients with isolated PCA occlusion stroke. There were no differences in clinical or safety outcomes between treatments, supporting randomization of future patients into distal vessel occlusion trials.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ene.15410","type":"journal-article","created":{"date-parts":[[2022,5,19]],"date-time":"2022-05-19T10:27:45Z","timestamp":1652956065000},"page":"2664-2673","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":42,"title":["Endovascular therapy versus no endovascular therapy in patients receiving best medical management for acute isolated occlusion of the posterior cerebral artery: A systematic review and<scp>meta\u2010analysis<\/scp>"],"prefix":"10.1111","volume":"29","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6991-1334","authenticated-orcid":false,"given":"Anne","family":"Berberich","sequence":"first","affiliation":[{"name":"Department of Neurology Heidelberg University Hospital Heidelberg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2140-7881","authenticated-orcid":false,"given":"Stephanos","family":"Finitsis","sequence":"additional","affiliation":[{"name":"Department of Radiology Aristotle University of Thessaloniki Thessaloniki Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Davide","family":"Strambo","sequence":"additional","affiliation":[{"name":"Department of Neurology Lausanne University Hospital and University of Lasaunne Lausanne Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrik","family":"Michel","sequence":"additional","affiliation":[{"name":"Department of Neurology Lausanne University Hospital and University of Lasaunne Lausanne Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Herweh","sequence":"additional","affiliation":[{"name":"Department of Neuroradiology Heidelberg University Hospital Heidelberg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3776-638X","authenticated-orcid":false,"given":"Lukas","family":"Meyer","sequence":"additional","affiliation":[{"name":"Department of Radiology Hamburg University Hospital Hamburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Uta","family":"Hanning","sequence":"additional","affiliation":[{"name":"Department of Radiology Hamburg University Hospital Hamburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Strbian","sequence":"additional","affiliation":[{"name":"Department of Neurology Helsinki University Hospital Helsinki Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9528-301X","authenticated-orcid":false,"given":"Mohamad","family":"Abdalkader","sequence":"additional","affiliation":[{"name":"Department of Radiology Boston Medical Center Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4532-153X","authenticated-orcid":false,"given":"Raul G.","family":"Nogueira","sequence":"additional","affiliation":[{"name":"UPMC Stroke Institute University of Pittsburgh Medical Center Pittsburgh Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1415-3027","authenticated-orcid":false,"given":"Volker","family":"Puetz","sequence":"additional","affiliation":[{"name":"Department of Neurology Dresden University Hospital Dresden Germany"},{"name":"Dresden Neurovascular Center Dresden University Hospital Dresden Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel P. O.","family":"Kaiser","sequence":"additional","affiliation":[{"name":"Dresden Neurovascular Center Dresden University Hospital Dresden Germany"},{"name":"Institute of Neuroradiology Dresden University Hospital Dresden Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marta","family":"Olive\u2010Gadea","sequence":"additional","affiliation":[{"name":"Stroke Unit, Department of Neurology Hospital Universitario Vall d'Hebron, Universitat Autonoma de Barcelona Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9931-4557","authenticated-orcid":false,"given":"Marc","family":"Ribo","sequence":"additional","affiliation":[{"name":"Stroke Unit, Department of Neurology Hospital Universitario Vall d'Hebron, Universitat Autonoma de Barcelona Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabel","family":"Fragata","sequence":"additional","affiliation":[{"name":"Department of Neuroradiology Centro Hospitalar Universit\u00e1rio de Lisboa Central Lisbon Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2277-5950","authenticated-orcid":false,"given":"Jo\u00e3o Pedro","family":"Marto","sequence":"additional","affiliation":[{"name":"Department of Neurology, Hospital de Egas Moniz Centro Hospitalar Lisboa Ocidental Lisbon Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8009-8543","authenticated-orcid":false,"given":"Michele","family":"Romoli","sequence":"additional","affiliation":[{"name":"Neurology and Stroke Unit, Department of Neuroscience Bufalini Hospital Cesena Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter A.","family":"Ringleb","sequence":"additional","affiliation":[{"name":"Department of Neurology Heidelberg University Hospital Heidelberg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thanh N.","family":"Nguyen","sequence":"additional","affiliation":[{"name":"Department of Neurology Radiology Boston Medical Center Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2471-6647","authenticated-orcid":false,"given":"Simon","family":"Nagel","sequence":"additional","affiliation":[{"name":"Department of Neurology Heidelberg University Hospital Heidelberg Germany"},{"name":"Department of Neurology Klinikum Ludwigshafen Ludwigshafen\/Rhein Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,6,17]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-1331.2011.03384.x"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1159\/000333610"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1159\/000016053"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.apmr.2005.07.289"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.119.026907"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(16)00163-X"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIR.0000000000000567"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.120.028956"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.120.030815"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2021.789836"},{"issue":"1","key":"e_1_2_9_12_1","first-page":"e000115","article-title":"Mechanical thrombectomy of the fetal posterior cerebral artery. 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