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Glucose\u20106\u2010phosphate dehydrogenase (G6PD) deficiency, a hereditary enzyme defect prevalent in Asian countries, has been associated with atherosclerotic cardiovascular disease and worse poststroke outcomes. However, the impact of G6PD deficiency on ICAS remains unclear. We aimed to compare the risk of ICAS in stroke patients with and without G6PD deficiency in a Chinese cohort.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We prospectively and consecutively recruited stroke patients from four centers in China. All patients received intracranial artery assessment by magnetic resonance\/computed tomography angiography or digital subtraction angiography, as well as G6PD enzyme evaluation. The prevalence, burden, and characteristics of ICAS were compared between patients with and without G6PD deficiency using multivariate regression analysis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Among 1593 patients, 116 (63.7%) of 182 patients with G6PD deficiency and 714 (50.6%) of 1411 patients with normal G6PD levels were identified as ICAS. Age, hypertension, diabetes, and G6PD deficiency were independent predictors of ICAS. Among patients with ICAS, G6PD\u2010deficient individuals were more likely to have multiple (\u22652 segments) intracranial stenosis (odds ratio [OR] =\u20091.87, 95% confidence interval [CI] =\u20091.25\u20132.81, <jats:italic>p<\/jats:italic>\u00a0=\u20090.002). G6PD deficiency increased the risk of ICAS in patients who were male (OR\u00a0=\u00a01.82, 95% CI\u00a0=\u00a01.24\u20132.66, <jats:italic>p<\/jats:italic>\u00a0=\u20090.002), aged \u226570\u2009years (OR\u00a0=\u00a02.40, 95% CI\u00a0=\u00a01.33\u20134.31, <jats:italic>p<\/jats:italic>\u00a0=\u20090.004), or hypertensive (OR\u00a0=\u00a01.88, 95% CI\u00a0=\u00a01.28\u20132.77, <jats:italic>p<\/jats:italic>\u00a0=\u20090.001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Stroke patients with G6PD deficiency have a higher prevalence and ICAS burden than those with normal G6PD, particularly those who are male, older, and hypertensive.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ene.15418","type":"journal-article","created":{"date-parts":[[2022,5,24]],"date-time":"2022-05-24T16:39:40Z","timestamp":1653410380000},"page":"2683-2689","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Glucose\u20106\u2010phosphate dehydrogenase deficiency and intracranial atherosclerotic stenosis in stroke patients"],"prefix":"10.1111","volume":"29","author":[{"given":"Jianle","family":"Li","sequence":"first","affiliation":[{"name":"Department of Neurology The First Affiliated Hospital Sun Yat\u2010sen University Guangdong Provincial Key Laboratory of Diagnosis and Treatment of Major Neurological Diseases National Key Clinical Department and Key Discipline of Neurology  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yicong","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Neurology The First Affiliated Hospital Sun Yat\u2010sen University Guangdong Provincial Key Laboratory of Diagnosis and Treatment of Major Neurological Diseases National Key Clinical Department and Key Discipline of Neurology  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zilin","family":"Ou","sequence":"additional","affiliation":[{"name":"Department of Neurology The First Affiliated Hospital Sun Yat\u2010sen University Guangdong Provincial Key Laboratory of Diagnosis and Treatment of Major Neurological Diseases National Key Clinical Department and Key Discipline of Neurology  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yusheng","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Neurology First Affiliated Hospital of Jinan University  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhijian","family":"Liang","sequence":"additional","affiliation":[{"name":"Department of Neurology First Affiliated Hospital of Guangxi Medical University  Nanning China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weisheng","family":"Deng","sequence":"additional","affiliation":[{"name":"Department of Neurology Meizhou People's Hospital  Meizhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hao","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Neurology First Affiliated Hospital of Guangxi Medical University  Nanning China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weixian","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Neurology The First Affiliated Hospital Sun Yat\u2010sen University Guangdong Provincial Key Laboratory of Diagnosis and Treatment of Major Neurological Diseases National Key Clinical Department and Key Discipline of Neurology  Guangzhou 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