{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,20]],"date-time":"2026-02-20T02:18:49Z","timestamp":1771553929923,"version":"3.50.1"},"reference-count":17,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2022,6,20]],"date-time":"2022-06-20T00:00:00Z","timestamp":1655683200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100010663","name":"H2020 European Research Council","doi-asserted-by":"publisher","award":["640580"],"award-info":[{"award-number":["640580"]}],"id":[{"id":"10.13039\/100010663","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010269","name":"Wellcome Trust","doi-asserted-by":"publisher","award":["203930\/B\/16\/Z"],"award-info":[{"award-number":["203930\/B\/16\/Z"]}],"id":[{"id":"10.13039\/100010269","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Euro J of Neurology"],"published-print":{"date-parts":[[2022,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and purpose<\/jats:title><jats:p>The purpose was to determine whether prior use of antiplatelet therapy modifies the effect of dual antiplatelet therapy in patients with acute minor ischaemic stroke or transient ischaemic attack.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A systematic review and meta\u2010analysis of randomized controlled trials was performed comparing dual antiplatelet therapy to aspirin that reported subgroup analysis by prior antiplatelet use, adhering to the Cochrane Collaboration Guidelines. A fixed\u2010effects meta\u2010analysis was used to estimate a pooled treatment effect overall in subgroups with prior aspirin therapy and without prior aspirin therapy. Difference in treatment effect was assessed by testing <jats:italic>p<\/jats:italic> for interaction. The primary outcome measure was recurrent vascular events.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Three eligible randomized controlled trials were identified, including 4831 participants with pre\u2010existing antiplatelet use and 16,236 participants without pre\u2010existing aspirin use. Recurrent vascular events occurred in 7.2% (95% confidence interval [<jats:styled-content style=\"fixed-case\">CI]<\/jats:styled-content> 4.3\u201310) of those without pre\u2010existing aspirin use versus 7.3% (95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 4.1\u201310) of those receiving prior aspirin therapy. Effect of dual antiplatelet therapy on the primary outcome measure was consistent in participants with no prior aspirin use (odds ratio 0.75, 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 0.66\u20130.84) compared to those taking aspirin before randomization (odds ratio 0.79, 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 0.63\u20130.998) (<jats:italic>p<\/jats:italic> interaction\u00a0=\u00a00.66). The number needed to treat in the aspirin\u2010na\u00efve group was 55 (95% CI 37\u2010107) compared to 66 (95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 32 to \u2013746) in those on prior aspirin therapy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>It was found that the effectiveness of dual antiplatelet therapy in patients with minor ischaemic stroke or high risk transient ischaemic attack does not significantly differ in patients with prior aspirin exposure; therefore there should be no influence on the decision to use dual antiplatelet therapy.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ene.15433","type":"journal-article","created":{"date-parts":[[2022,6,2]],"date-time":"2022-06-02T13:49:27Z","timestamp":1654177767000},"page":"2864-2868","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Does prior use of antiplatelet therapy modify the effect of dual antiplatelet therapy in transient ischaemic attack\/minor ischaemic stroke: A systematic review and meta\u2010analysis"],"prefix":"10.1111","volume":"29","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5265-3351","authenticated-orcid":false,"given":"Aoibhin","family":"Clarke","sequence":"first","affiliation":[{"name":"HRB\u2014Clinical Research Facility National University of Ireland Galway  Galway Ireland"},{"name":"Galway University Hospital  Galway Ireland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Catriona","family":"Reddin","sequence":"additional","affiliation":[{"name":"HRB\u2014Clinical Research Facility National University of Ireland Galway  Galway Ireland"},{"name":"Galway University Hospital  Galway Ireland"},{"name":"Wellcome Trust\u2014HRB, Irish Clinical Academic Training  Dublin Ireland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5446-4175","authenticated-orcid":false,"given":"Robert","family":"Murphy","sequence":"additional","affiliation":[{"name":"HRB\u2014Clinical Research Facility National University of Ireland Galway  Galway Ireland"},{"name":"Galway University Hospital  Galway Ireland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martin J.","family":"O'Donnell","sequence":"additional","affiliation":[{"name":"HRB\u2014Clinical Research Facility National University of Ireland Galway  Galway Ireland"},{"name":"Galway University Hospital  Galway Ireland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,6,20]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1161\/STR.0000000000000375"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.120.033033"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.k5108"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1412981"},{"key":"e_1_2_10_6_1","unstructured":"HigginsJPT WelchV(editors).Cochrane Handbook for Systematic Reviews of Interventions version 6.0 (updated July 2019). 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