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However, the debate regarding the possible role of infection in causing GBS is still ongoing. This multicenter study aimed to evaluate epidemiological and clinical findings of GBS diagnosed during the COVID\u201019 pandemic in northeastern Italy in order to further investigate the possible association between GBS and COVID\u201019.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Guillain\u2013Barr\u00e9 syndrome cases diagnosed in 14 referral hospitals from northern Italy between March 2020 and March 2021 were collected and divided into COVID\u201019\u2010positive and COVID\u201019\u2010negative. As a control population, GBS patients diagnosed in the same hospitals from January 2019 to February 2020 were considered.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The estimated incidence of GBS in 2020 was 1.41 cases per 100,000\u2009persons\/year (95% confidence interval 1.18\u20131.68) versus 0.89 cases per 100,000\u2009persons\/year (95% confidence interval 0.71\u20131.11) in 2019. The cumulative incidence of GBS increased by 59% in the period March 2020\u2013March 2021 and, most importantly, COVID\u201019\u2010positive GBS patients represented about 50% of the total GBS cases with most of them occurring during the two first pandemic waves in spring and autumn 2020. COVID\u201019\u2010negative GBS cases from March 2020 to March 2021 declined by 22% compared to February 2019\u2013February 2020.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Other than showing an increase of GBS in northern Italy in the \u201cCOVID\u201019 era\u201d compared to the previous year, this study emphasizes how GBS cases related to COVID\u201019 represent a significant part of the total, thus suggesting a relation between COVID\u201019 and GBS.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ene.15497","type":"journal-article","created":{"date-parts":[[2022,7,15]],"date-time":"2022-07-15T07:44:03Z","timestamp":1657871043000},"page":"3358-3367","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":36,"title":["<scp>Guillain\u2010Barr\u00e9<\/scp> syndrome and <scp>COVID<\/scp>\u201019: A 1\u2010year observational multicenter 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