{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T01:41:06Z","timestamp":1790991666187,"version":"4.1.0"},"reference-count":47,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2022,8,2]],"date-time":"2022-08-02T00:00:00Z","timestamp":1659398400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Euro J of Neurology"],"published-print":{"date-parts":[[2022,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and purpose<\/jats:title><jats:p>Intravenous immunoglobulin (IVIg) is recommended in Guillain\u2013Barr\u00e9 syndrome (GBS), but its efficacy may vary in different subtypes. We report the outcomes of patients with GBS following IVIg treatment compared to the natural course (NC). We also compare the effect of IVIg treatment in different subtypes of GBS.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>From a cohort of 528 GBS subjects, we have extracted 189 patients who received IVIg and compared their outcomes with 199 age\u2010 and peak disability\u2010matched patients who did not receive IVIg, plasmapheresis, or corticosteroid. Disability was assessed using the 0\u20136 Guillain\u2013Barr\u00e9 Syndrome Disability Scale (GBSDS). Clinical and neurophysiological subtypes were recorded. The primary outcome was functional disability at 6 months, which was categorized as complete (GBSDS \u2264\u20091), partial (GBSDS 2\u20133), or poor (GBSDS &gt;\u20093). The secondary outcomes were in\u2010hospital death, duration of hospitalization, and mechanical ventilation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In\u2010hospital death (2.6% vs. 2%, <jats:italic>p<\/jats:italic>\u00a0=\u00a00.74) and 3\u2010month poor recovery (20.7% vs. 18%) were similar in the IVIg and NC groups. At 6 months, however, a lesser proportion of patients in the IVIg group had poor recovery (2.2% vs. 8.3%, <jats:italic>p<\/jats:italic>\u00a0=\u00a00.026). The outcomes of IVIg and NC were compared in 72 acute motor axonal neuropathy (AMAN) and 256 acute inflammatory demyelinating polyradiculoneuropathy (AIDP) patients. IVIg therapy did not alter the outcome in AMAN but resulted in a lesser proportion of poor recovery at 6 months in AIDP (0.8% vs. 6.6%, <jats:italic>p<\/jats:italic>\u00a0=\u00a00.03).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>IVIg is beneficial in AIDP variants of GBS but not in the AMAN subtype. A customized treatment may be cost\u2010effective until a randomized controlled trial is conducted in AMAN.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ene.15500","type":"journal-article","created":{"date-parts":[[2022,7,15]],"date-time":"2022-07-15T07:43:34Z","timestamp":1657871014000},"page":"3071-3080","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Outcome of <scp>Guillain\u2013Barr\u00e9<\/scp> syndrome following intravenous immunoglobulin compared to natural course"],"prefix":"10.1111","volume":"29","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6141-3592","authenticated-orcid":false,"given":"Jayantee","family":"Kalita","sequence":"first","affiliation":[{"name":"Department of Neurology Sanjay Gandhi Post Graduate Institute of Medical Sciences  Lucknow India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7317-957X","authenticated-orcid":false,"given":"Usha K.","family":"Misra","sequence":"additional","affiliation":[{"name":"Department of Neurology Apollomedics Super Specialty Hospitals  Lucknow India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarvesh K.","family":"Chaudhary","sequence":"additional","affiliation":[{"name":"Department of Neurology Sanjay Gandhi Post Graduate Institute of Medical Sciences  Lucknow India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Moromi","family":"Das","sequence":"additional","affiliation":[{"name":"Department of Neurology Guwahati Medical College  Guwahati India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anadi","family":"Mishra","sequence":"additional","affiliation":[{"name":"Department of Neurology Sanjay Gandhi Post Graduate Institute of Medical Sciences  Lucknow India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abhay","family":"Ranjan","sequence":"additional","affiliation":[{"name":"Department of Neurology Indira Gandhi Institute of Medical Sciences  Patna India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4113-9186","authenticated-orcid":false,"given":"Mritunjai","family":"Kumar","sequence":"additional","affiliation":[{"name":"Department of Neurology All India Institute of Medical Sciences (AIIMS)  Rishikesh India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,8,2]]},"reference":[{"key":"e_1_2_15_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrneurol.2016.172"},{"key":"e_1_2_15_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(21)00517-1"},{"key":"e_1_2_15_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mayocp.2016.12.002"},{"key":"e_1_2_15_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/qjmed\/hcv190"},{"key":"e_1_2_15_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41582-019-0250-9"},{"key":"e_1_2_15_7_1","doi-asserted-by":"publisher","DOI":"10.1080\/1744666X.2016.1193006"},{"key":"e_1_2_15_8_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.37.5.837"},{"key":"e_1_2_15_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(84)91341-2"},{"key":"e_1_2_15_10_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.35.8.1096"},{"key":"e_1_2_15_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(84)90819-5"},{"key":"e_1_2_15_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410220612"},{"key":"e_1_2_15_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410410304"},{"key":"e_1_2_15_14_1","doi-asserted-by":"publisher","DOI":"10.2174\/157015909790031166"},{"key":"e_1_2_15_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(81)92400-4"},{"key":"e_1_2_15_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/0022-510X(85)90173-X"},{"key":"e_1_2_15_17_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199204233261705"},{"key":"e_1_2_15_18_1","first-page":"CD002063","article-title":"Intravenous immunoglobulin for Guillain\u2010Barr\u00e9 syndrome","volume":"2014","author":"Hughes RA","year":"2014","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_2_15_19_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2004-1324"},{"key":"e_1_2_15_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/1531-8249(199902)45:2<168::AID-ANA6>3.0.CO;2-6"},{"key":"e_1_2_15_21_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrneurol.2014.121"},{"key":"e_1_2_15_22_1","doi-asserted-by":"publisher","DOI":"10.1097\/PCC.0000000000001935"},{"key":"e_1_2_15_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/jns.12209"},{"key":"e_1_2_15_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/mus.25992"},{"key":"e_1_2_15_25_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410270707"},{"key":"e_1_2_15_26_1","volume-title":"Aids to examination of the peripheral nervous system. 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