{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,19]],"date-time":"2025-12-19T09:54:28Z","timestamp":1766138068669,"version":"3.40.5"},"reference-count":31,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2022,9,21]],"date-time":"2022-09-21T00:00:00Z","timestamp":1663718400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100012686","name":"Deutsche Stiftung Neurologie","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100012686","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Euro J of Neurology"],"published-print":{"date-parts":[[2022,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and purpose<\/jats:title><jats:p>Dizziness and vertigo are common symptoms after COVID\u201019\u2010vaccination. We aimed to prospectively evaluate objective central or peripheral vestibular function in patients with dizziness, vertigo, and postural symptoms that started or worsened after COVID\u201019\u2010vaccination.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Of 4137 patients who presented between January 2021 and April 2022 at the German Center for Vertigo and Balance Disorders, Ludwig Maximilian University of Munich, we identified 72 patients (mean age\u00a0=\u00a047\u2009years) with enduring vestibular symptoms following COVID\u201019 vaccination. All underwent medical history\u2010taking, and neurological and neuro\u2010otological workup with bithermal caloric test, video head\u2010impulse test, orthoptics, and audiometry. Diagnoses were based on international criteria. The distribution of diagnoses was compared to a cohort of 39,964 patients seen before the COVID\u201019 pandemic.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Symptom onset was within the first 4\u2009weeks postvaccination. The most prevalent diagnoses were somatoform vestibular disorders (34.7%), vestibular migraine (19.4%), and overlap syndromes of both (18.1%). These disorders were significantly overrepresented compared to the prepandemic control cohort. Thirty\u2010six percent of patients with somatoform complaints reported a positive history of depressive or anxiety disorders. Nine patients presented with benign paroxysmal positional vertigo, three with acute unilateral vestibulopathy, and seven with different entities (vestibular paroxysmia, M\u00e9ni\u00e8re disease, polyneuropathy, ocular muscular paresis). Causally related central vestibular deficits were lacking. Novel peripheral vestibular deficits were found in four patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Newly induced persistent vestibular deficits following COVID\u201019 vaccination were rare. The predominant causes of prolonged vestibular complaints were somatoform vestibular disorders and vestibular migraine, possibly triggered or aggravated by stress\u2010related circumstances due to the COVID\u201019 pandemic or vaccination. An increase of other central or peripheral vestibular syndromes after COVID\u201019 vaccination was not observed.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ene.15546","type":"journal-article","created":{"date-parts":[[2022,9,3]],"date-time":"2022-09-03T13:24:06Z","timestamp":1662211446000},"page":"3693-3700","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Vestibular syndromes after <scp>COVID<\/scp>\u201019 vaccination: A prospective cohort study"],"prefix":"10.1111","volume":"29","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5053-1462","authenticated-orcid":false,"given":"Johannes","family":"Gerb","sequence":"first","affiliation":[{"name":"German Center for Vertigo and Balance Disorders Ludwig Maximilian University of Munich  Munich Germany"},{"name":"Department of Neurology Ludwig Maximilian University of Munich  Munich Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sandra","family":"Becker\u2010Bense","sequence":"additional","affiliation":[{"name":"German Center for Vertigo and Balance Disorders Ludwig Maximilian University of Munich  Munich Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3839-8398","authenticated-orcid":false,"given":"Andreas","family":"Zwergal","sequence":"additional","affiliation":[{"name":"German Center for Vertigo and Balance Disorders Ludwig Maximilian University of Munich  Munich Germany"},{"name":"Department of Neurology Ludwig Maximilian University of Munich  Munich Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Doreen","family":"Huppert","sequence":"additional","affiliation":[{"name":"German Center for Vertigo and Balance Disorders Ludwig Maximilian University of Munich  Munich Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,9,21]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/MAO.0000000000000691"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.3233\/VES-2009-0343"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrneurol.2017.58"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00429-014-0971-x"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/WCO.0000000000000417"},{"key":"e_1_2_11_7_1","unstructured":"Coronavirus und COVID\u201019 \u2010 Sicherheit von COVID\u201019\u2010Impfstoffen.https:\/\/www.pei.de\/DE\/newsroom\/dossier\/coronavirus\/arzneimittelsicherheit.html. 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